diff --git a/Modules/_functoolsmodule.c b/Modules/_functoolsmodule.c
index ab0839cdc7473b..0c0fae1a979a4f 100644
--- a/Modules/_functoolsmodule.c
+++ b/Modules/_functoolsmodule.c
@@ -573,7 +573,7 @@ keyobject_richcompare(PyObject *ko, PyObject *other, int op)
     PyObject *answer;
     PyObject* stack[2];
 
-    if (Py_TYPE(other) != &keyobject_type){
+    if (!Py_IS_TYPE(other, &keyobject_type)) {
         PyErr_Format(PyExc_TypeError, "other argument must be K instance");
         return NULL;
     }
diff --git a/Modules/_threadmodule.c b/Modules/_threadmodule.c
index da5fe7915a8e52..11bc16f4b3111f 100644
--- a/Modules/_threadmodule.c
+++ b/Modules/_threadmodule.c
@@ -938,7 +938,7 @@ local_getattro(localobject *self, PyObject *name)
     if (r == -1)
         return NULL;
 
-    if (Py_TYPE(self) != &localtype)
+    if (!Py_IS_TYPE(self, &localtype))
         /* use generic lookup for subtypes */
         return _PyObject_GenericGetAttrWithDict(
             (PyObject *)self, name, ldict, 0);
@@ -1400,7 +1400,7 @@ static PyStructSequence_Desc ExceptHookArgs_desc = {
 static PyObject *
 thread_excepthook(PyObject *self, PyObject *args)
 {
-    if (Py_TYPE(args) != &ExceptHookArgsType) {
+    if (!Py_IS_TYPE(args, &ExceptHookArgsType)) {
         PyErr_SetString(PyExc_TypeError,
                         "_thread.excepthook argument type "
                         "must be ExceptHookArgs");
diff --git a/Modules/itertoolsmodule.c b/Modules/itertoolsmodule.c
index d545028901b4ee..9505fd454b42e6 100644
--- a/Modules/itertoolsmodule.c
+++ b/Modules/itertoolsmodule.c
@@ -614,7 +614,7 @@ itertools_teedataobject_impl(PyTypeObject *type, PyObject *it,
 
     if (len == LINKCELLS) {
         if (next != Py_None) {
-            if (Py_TYPE(next) != &teedataobject_type)
+            if (!Py_IS_TYPE(next, &teedataobject_type))
                 goto err;
             assert(tdo->nextlink == NULL);
             Py_INCREF(next);
diff --git a/Modules/posixmodule.c b/Modules/posixmodule.c
index 4d6d255b3469b2..29aeca4169dd17 100644
--- a/Modules/posixmodule.c
+++ b/Modules/posixmodule.c
@@ -6380,8 +6380,7 @@ convert_sched_param(PyObject *param, struct sched_param *res)
 {
     long priority;
 
-    PyObject *SchedParamType = _posixstate_global->SchedParamType;
-    if (Py_TYPE(param) != (PyTypeObject *)SchedParamType) {
+    if (!Py_IS_TYPE(param, (PyTypeObject *)_posixstate_global->SchedParamType)) {
         PyErr_SetString(PyExc_TypeError, "must have a sched_param object");
         return 0;
     }
diff --git a/Objects/abstract.c b/Objects/abstract.c
index 454e0da71afbe0..accd72d5f28e5d 100644
--- a/Objects/abstract.c
+++ b/Objects/abstract.c
@@ -834,7 +834,7 @@ binary_op1(PyObject *v, PyObject *w, const int op_slot)
 
     if (Py_TYPE(v)->tp_as_number != NULL)
         slotv = NB_BINOP(Py_TYPE(v)->tp_as_number, op_slot);
-    if (Py_TYPE(w) != Py_TYPE(v) &&
+    if (!Py_IS_TYPE(w, Py_TYPE(v)) &&
         Py_TYPE(w)->tp_as_number != NULL) {
         slotw = NB_BINOP(Py_TYPE(w)->tp_as_number, op_slot);
         if (slotw == slotv)
@@ -925,8 +925,7 @@ ternary_op(PyObject *v,
     mw = Py_TYPE(w)->tp_as_number;
     if (mv != NULL)
         slotv = NB_TERNOP(mv, op_slot);
-    if (Py_TYPE(w) != Py_TYPE(v) &&
-        mw != NULL) {
+    if (!Py_IS_TYPE(w, Py_TYPE(v)) && mw != NULL) {
         slotw = NB_TERNOP(mw, op_slot);
         if (slotw == slotv)
             slotw = NULL;
diff --git a/Objects/object.c b/Objects/object.c
index 8314a08150e2db..bb47cfa8585f79 100644
--- a/Objects/object.c
+++ b/Objects/object.c
@@ -657,7 +657,7 @@ do_richcompare(PyThreadState *tstate, PyObject *v, PyObject *w, int op)
     PyObject *res;
     int checked_reverse_op = 0;
 
-    if (Py_TYPE(v) != Py_TYPE(w) &&
+    if (!Py_IS_TYPE(v, Py_TYPE(w)) &&
         PyType_IsSubtype(Py_TYPE(w), Py_TYPE(v)) &&
         (f = Py_TYPE(w)->tp_richcompare) != NULL) {
         checked_reverse_op = 1;
@@ -1907,7 +1907,7 @@ _Py_GetObjects(PyObject *self, PyObject *args)
         return NULL;
     for (i = 0; (n == 0 || i < n) && op != &refchain; i++) {
         while (op == self || op == args || op == res || op == t ||
-               (t != NULL && Py_TYPE(op) != (PyTypeObject *) t)) {
+               (t != NULL && !Py_IS_TYPE(op, (PyTypeObject *) t))) {
             op = op->_ob_next;
             if (op == &refchain)
                 return res;
diff --git a/Objects/setobject.c b/Objects/setobject.c
index bb7c0b8f0456b8..43fa5d17fd2e79 100644
--- a/Objects/setobject.c
+++ b/Objects/setobject.c
@@ -608,7 +608,7 @@ set_repr(PySetObject *so)
         goto done;
     listrepr = tmp;
 
-    if (Py_TYPE(so) != &PySet_Type)
+    if (!Py_IS_TYPE(so, &PySet_Type))
         result = PyUnicode_FromFormat("%s({%U})",
                                       Py_TYPE(so)->tp_name,
                                       listrepr);
diff --git a/Objects/tupleobject.c b/Objects/tupleobject.c
index 92374cc130d0c2..52ecb5446fe8fc 100644
--- a/Objects/tupleobject.c
+++ b/Objects/tupleobject.c
@@ -881,7 +881,7 @@ _PyTuple_Resize(PyObject **pv, Py_ssize_t newsize)
     Py_ssize_t oldsize;
 
     v = (PyTupleObject *) *pv;
-    if (v == NULL || Py_TYPE(v) != &PyTuple_Type ||
+    if (v == NULL || !Py_IS_TYPE(v, &PyTuple_Type) ||
         (Py_SIZE(v) != 0 && Py_REFCNT(v) != 1)) {
         *pv = 0;
         Py_XDECREF(v);
diff --git a/Objects/typeobject.c b/Objects/typeobject.c
index cf749eff58fe2e..ec8dc19da9998a 100644
--- a/Objects/typeobject.c
+++ b/Objects/typeobject.c
@@ -1889,7 +1889,7 @@ mro_invoke(PyTypeObject *type)
 {
     PyObject *mro_result;
     PyObject *new_mro;
-    int custom = (Py_TYPE(type) != &PyType_Type);
+    const int custom = !Py_IS_TYPE(type, &PyType_Type);
 
     if (custom) {
         int unbound;
@@ -6191,7 +6191,7 @@ FUNCNAME(PyObject *self, PyObject *other) \
     PyThreadState *tstate = _PyThreadState_GET(); \
     _Py_static_string(op_id, OPSTR); \
     _Py_static_string(rop_id, ROPSTR); \
-    int do_other = Py_TYPE(self) != Py_TYPE(other) && \
+    int do_other = !Py_IS_TYPE(self, Py_TYPE(other)) && \
         Py_TYPE(other)->tp_as_number != NULL && \
         Py_TYPE(other)->tp_as_number->SLOTNAME == TESTFUNC; \
     if (Py_TYPE(self)->tp_as_number != NULL && \
@@ -7901,7 +7901,7 @@ super_descr_get(PyObject *self, PyObject *obj, PyObject *type)
         Py_INCREF(self);
         return self;
     }
-    if (Py_TYPE(su) != &PySuper_Type)
+    if (!Py_IS_TYPE(su, &PySuper_Type))
         /* If su is an instance of a (strict) subclass of super,
            call its type */
         return PyObject_CallFunctionObjArgs((PyObject *)Py_TYPE(su),
diff --git a/Python/errors.c b/Python/errors.c
index 6baa229ccc7ce8..4656fb2a336706 100644
--- a/Python/errors.c
+++ b/Python/errors.c
@@ -1321,7 +1321,7 @@ _PyErr_WriteUnraisableDefaultHook(PyObject *args)
 {
     PyThreadState *tstate = _PyThreadState_GET();
 
-    if (Py_TYPE(args) != &UnraisableHookArgsType) {
+    if (!Py_IS_TYPE(args, &UnraisableHookArgsType)) {
         _PyErr_SetString(tstate, PyExc_TypeError,
                          "sys.unraisablehook argument type "
                          "must be UnraisableHookArgs");