diff --git a/Include/internal/pycore_sysmodule.h b/Include/internal/pycore_sysmodule.h
index 10d092cdc30a2c..79380f7172907e 100644
--- a/Include/internal/pycore_sysmodule.h
+++ b/Include/internal/pycore_sysmodule.h
@@ -8,6 +8,10 @@ extern "C" {
 #  error "this header requires Py_BUILD_CORE define"
 #endif
 
+#ifdef HAVE_FORK
+extern PyStatus _PySys_ReInitStdio(void);
+#endif
+
 PyAPI_FUNC(int) _PySys_Audit(
     PyThreadState *tstate,
     const char *event,
diff --git a/Lib/test/test_thread.py b/Lib/test/test_thread.py
index d55fb731b6df54..18c1088becb211 100644
--- a/Lib/test/test_thread.py
+++ b/Lib/test/test_thread.py
@@ -1,4 +1,6 @@
+import io
 import os
+import sys
 import unittest
 import random
 from test import support
@@ -265,5 +267,107 @@ def tearDown(self):
             pass
 
 
+class TestStdioAtForkReInit(unittest.TestCase):
+
+    class MockStdio(io.TextIOWrapper):
+        def __init__(self):
+            import _io, tempfile
+            self._file = tempfile.mktemp()
+            raw = _io.FileIO(self._file, mode='wb')
+            buffer = _io.BufferedWriter(raw)
+            super().__init__(buffer)
+
+        def __del__(self):
+            try:
+                self.close()
+                os.remove(self._file)
+            except:
+                pass
+
+        def isatty(self):
+            # pretend to be a tty, so _PySys_ReInitStdio
+            # will attempt to reinitialize our buffer lock.
+            return True
+
+    def setUp(self):
+        # Replace stdout & stderr with mock objects with the
+        # same underlying buffer type to avoid polluting the
+        # test output stream.
+        self._saved_stdout = sys.stdout
+        self._saved_stderr = sys.stderr
+        sys.stdout = self.MockStdio()
+        sys.stderr = self.MockStdio()
+
+    def tearDown(self):
+        sys.stdout = self._saved_stdout
+        sys.stderr = self._saved_stderr
+
+    @unittest.skipUnless(hasattr(os, 'fork'), 'need os.fork')
+    @threading_helper.reap_threads
+    def test_stdio_at_fork_reinit(self):
+
+        # bpo-46210: Added _PySys_ReInitStdio to prevent children
+        # from deadlocking here if printer_thread held the stdout
+        # (or stderr) buffer's lock when one of the children forked.
+
+        num_prints = 100
+        num_forks = 100
+        msg = 'hello'*10
+
+        def printer_thread(stdio):
+            for n in range(num_prints):
+                print(msg, file=stdio)
+                stdio.flush()
+
+        def fork_processes(stdio):
+            pids = []
+            for n in range(num_forks):
+                if pid := os.fork():
+                    pids.append(pid)
+                else:
+                    print(msg, file=stdio)
+                    stdio.flush()
+                    os._exit(0)
+
+            return pids
+
+        def main(stdio):
+            thread.start_new_thread(printer_thread, (stdio,))
+            pids = fork_processes(stdio)
+            for pid in pids:
+                support.wait_process(pid, exitcode=0)
+            return
+
+        # Forking below is not necessary to illustrate the bug
+        # in bpo-46210 and its fix. The issue in bpo-46210 is
+        # that calling main(sys.stdout) or main(sys.stderr)
+        # is sufficient to cause a deadlock in print. We fork
+        # here only to allow us to give a single timeout to the
+        # main() call, since its failure mode (absent the fix)
+        # is for some subset of the forked child processes to
+        # deadlock at the moment when they try to print, rather
+        # than to raise an exception. Therefore, simply looping
+        # over the child pids and calling support.wait_process
+        # with a separate nonzero timeout for each child leads
+        # to a rather unpredictable total wait time, whereas
+        # forking again here at the top (though not necessary
+        # to illustrate the bug) allows us to give a predictable
+        # timeout to the process of waiting for the children.
+        #
+        # bpo-46210 is present if and only if one or more of the
+        # children forked by main() deadlock when they call print.
+        #
+        # pr-30310 proposes a fix following the example of the
+        # import lock, by providing a function _PySys_ReInitStdio
+        # that is called alongside the other preexisting lock
+        # reinitialization functions in PyOS_AfterFork_Child.
+        for stdio in (sys.stdout, sys.stderr):
+            with threading_helper.wait_threads_exit():
+                if main_pid := os.fork():
+                    support.wait_process(main_pid, exitcode=0, timeout=5)
+                else:
+                    main(stdio)
+                    os._exit(0)
+
 if __name__ == "__main__":
     unittest.main()
diff --git a/Misc/NEWS.d/next/Core and Builtins/2021-12-30-15-50-39.bpo-46210.YRy67_.rst b/Misc/NEWS.d/next/Core and Builtins/2021-12-30-15-50-39.bpo-46210.YRy67_.rst
new file mode 100644
index 00000000000000..c3ca26debf2a01
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2021-12-30-15-50-39.bpo-46210.YRy67_.rst	
@@ -0,0 +1,2 @@
+Add :c:func:`_at_fork_reinit` handler to ``buffer->lock`` of stdout and
+stderr, to fix a deadlock in print.
diff --git a/Modules/_io/bufferedio.c b/Modules/_io/bufferedio.c
index bb93ae361f8925..a5a37470d91bfc 100644
--- a/Modules/_io/bufferedio.c
+++ b/Modules/_io/bufferedio.c
@@ -414,6 +414,20 @@ buffered_clear(buffered *self)
     return 0;
 }
 
+#ifdef HAVE_FORK
+int
+_PyIO_buffered_at_fork_reinit(PyObject *self)
+{
+    if (!Py_IS_TYPE(self, &PyBufferedWriter_Type) &&
+        !Py_IS_TYPE(self, &PyBufferedReader_Type)) {
+        return 0;
+    }
+    buffered *buffer = (buffered *)self;
+    buffer->owner = 0;
+    return _PyThread_at_fork_reinit(&buffer->lock);
+}
+#endif
+
 /* Because this can call arbitrary code, it shouldn't be called when
    the refcount is 0 (that is, not directly from tp_dealloc unless
    the refcount has been temporarily re-incremented). */
diff --git a/Modules/posixmodule.c b/Modules/posixmodule.c
index 6ef3610fce7c5e..7f82f8482b7b3b 100644
--- a/Modules/posixmodule.c
+++ b/Modules/posixmodule.c
@@ -25,6 +25,7 @@
 #include "pycore_ceval.h"         // _PyEval_ReInitThreads()
 #include "pycore_fileutils.h"     // _Py_closerange()
 #include "pycore_import.h"        // _PyImport_ReInitLock()
+#include "pycore_sysmodule.h"     // _PySys_ReInitStdio()
 #include "pycore_initconfig.h"    // _PyStatus_EXCEPTION()
 #include "pycore_moduleobject.h"  // _PyModule_GetState()
 #include "pycore_object.h"        // _PyObject_LookupSpecial()
@@ -592,6 +593,11 @@ PyOS_AfterFork_Child(void)
         goto fatal_error;
     }
 
+    status = _PySys_ReInitStdio();
+    if (_PyStatus_EXCEPTION(status)) {
+        goto fatal_error;
+    }
+
     _PySignal_AfterFork();
 
     status = _PyRuntimeState_ReInitThreads(runtime);
diff --git a/Python/sysmodule.c b/Python/sysmodule.c
index 57bf04dd306aee..aa0d2d5f03877b 100644
--- a/Python/sysmodule.c
+++ b/Python/sysmodule.c
@@ -2895,6 +2895,53 @@ _PySys_InitCore(PyThreadState *tstate, PyObject *sysdict)
     return _PyStatus_ERR("can't initialize sys module");
 }
 
+#ifdef HAVE_FORK
+extern int _PyIO_buffered_at_fork_reinit(PyObject *);
+
+static int
+stream_at_fork_reinit(PyObject *stream)
+{
+    if (stream == NULL || Py_IsNone(stream)) {
+        return 0;
+    }
+
+    /* The buffer attribute is not part of the TextIOBase API
+     * and may not exist in some implementations. If not present,
+     * we have no locks to reinitialize. */
+    PyObject *buffer = PyObject_GetAttr(stream, &_Py_ID(buffer));
+    if (buffer == NULL) {
+        PyErr_Clear();
+        return 0;
+    }
+
+    /* Reinitialize buffer->lock */
+    int ret = _PyIO_buffered_at_fork_reinit(buffer);
+    Py_DECREF(buffer);
+    return ret;
+}
+
+/* This function is called from PyOS_AfterFork_Child() to ensure that newly
+   created child processes do not share locks with the parent. */
+PyStatus
+_PySys_ReInitStdio(void)
+{
+    PyThreadState *tstate = _PyThreadState_GET();
+
+    PyObject *sys_stdin  = _PySys_GetAttr(tstate, &_Py_ID(stdin));
+    PyObject *sys_stdout = _PySys_GetAttr(tstate, &_Py_ID(stdout));
+    PyObject *sys_stderr = _PySys_GetAttr(tstate, &_Py_ID(stderr));
+
+    int reinit_stdin  = stream_at_fork_reinit(sys_stdin);
+    int reinit_stdout = stream_at_fork_reinit(sys_stdout);
+    int reinit_stderr = stream_at_fork_reinit(sys_stderr);
+
+    if (reinit_stdin < 0 || reinit_stdout < 0 || reinit_stderr < 0) {
+        return _PyStatus_ERR("Failed to reinitialize standard streams");
+    }
+    return _PyStatus_OK();
+}
+#endif
+
 static int
 sys_add_xoption(PyObject *opts, const wchar_t *s)
 {