diff --git a/Lib/test/libregrtest/main.py b/Lib/test/libregrtest/main.py
index 19ccf2db5e7f06..3c3509d0303371 100644
--- a/Lib/test/libregrtest/main.py
+++ b/Lib/test/libregrtest/main.py
@@ -29,6 +29,14 @@
 # Must be smaller than buildbot "1200 seconds without output" limit.
 EXIT_TIMEOUT = 120.0
 
+# gh-90681: When rerunning tests, we might need to rerun the whole
+# class or module suite if some its life-cycle hooks fail.
+# Test level hooks are not affected.
+_TEST_LIFECYCLE_HOOKS = frozenset((
+    'setUpClass', 'tearDownClass',
+    'setUpModule', 'tearDownModule',
+))
+
 EXITCODE_BAD_TEST = 2
 EXITCODE_INTERRUPTED = 130
 EXITCODE_ENV_CHANGED = 3
@@ -337,8 +345,12 @@ def rerun_failed_tests(self):
 
             errors = result.errors or []
             failures = result.failures or []
-            error_names = [test_full_name.split(" ")[0] for (test_full_name, *_) in errors]
-            failure_names = [test_full_name.split(" ")[0] for (test_full_name, *_) in failures]
+            error_names = [
+                self.normalize_test_name(test_full_name, is_error=True)
+                for (test_full_name, *_) in errors]
+            failure_names = [
+                self.normalize_test_name(test_full_name)
+                for (test_full_name, *_) in failures]
             self.ns.verbose = True
             orig_match_tests = self.ns.match_tests
             if errors or failures:
@@ -364,6 +376,21 @@ def rerun_failed_tests(self):
 
         self.display_result()
 
+    def normalize_test_name(self, test_full_name, *, is_error=False):
+        short_name = test_full_name.split(" ")[0]
+        if is_error and short_name in _TEST_LIFECYCLE_HOOKS:
+            # This means that we have a failure in a life-cycle hook,
+            # we need to rerun the whole module or class suite.
+            # Basically the error looks like this:
+            #    ERROR: setUpClass (test.test_reg_ex.RegTest)
+            # or
+            #    ERROR: setUpModule (test.test_reg_ex)
+            # So, we need to parse the class / module name.
+            lpar = test_full_name.index('(')
+            rpar = test_full_name.index(')')
+            return test_full_name[lpar + 1: rpar].split('.')[-1]
+        return short_name
+
     def display_result(self):
         # If running the test suite for PGO then no one cares about results.
         if self.ns.pgo:
diff --git a/Lib/test/support/__init__.py b/Lib/test/support/__init__.py
index c309fd7910e0e6..d063837baee2de 100644
--- a/Lib/test/support/__init__.py
+++ b/Lib/test/support/__init__.py
@@ -1108,7 +1108,7 @@ def _run_suite(suite):
     if junit_xml_list is not None:
         junit_xml_list.append(result.get_xml_element())
 
-    if not result.testsRun and not result.skipped:
+    if not result.testsRun and not result.skipped and not result.errors:
         raise TestDidNotRun
     if not result.wasSuccessful():
         if len(result.errors) == 1 and not result.failures:
diff --git a/Lib/test/test_regrtest.py b/Lib/test/test_regrtest.py
index baae4efc2ad789..ac49fbae847726 100644
--- a/Lib/test/test_regrtest.py
+++ b/Lib/test/test_regrtest.py
@@ -1120,6 +1120,160 @@ def test_fail_once(self):
         self.check_executed_tests(output, [testname],
                                   rerun={testname: "test_fail_once"})
 
+    def test_rerun_setup_class_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.TestCase):
+                @classmethod
+                def setUpClass(self):
+                    raise RuntimeError('Fail')
+
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "ExampleTests"})
+
+    def test_rerun_teardown_class_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.TestCase):
+                @classmethod
+                def tearDownClass(self):
+                    raise RuntimeError('Fail')
+
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "ExampleTests"})
+
+    def test_rerun_setup_module_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            def setUpModule():
+                raise RuntimeError('Fail')
+
+            class ExampleTests(unittest.TestCase):
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: testname})
+
+    def test_rerun_teardown_module_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            def tearDownModule():
+                raise RuntimeError('Fail')
+
+            class ExampleTests(unittest.TestCase):
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: testname})
+
+    def test_rerun_setup_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.TestCase):
+                def setUp(self):
+                    raise RuntimeError('Fail')
+
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "test_success"})
+
+    def test_rerun_teardown_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.TestCase):
+                def tearDown(self):
+                    raise RuntimeError('Fail')
+
+                def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "test_success"})
+
+    def test_rerun_async_setup_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.IsolatedAsyncioTestCase):
+                async def asyncSetUp(self):
+                    raise RuntimeError('Fail')
+
+                async def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "test_success"})
+
+    def test_rerun_async_teardown_hook_failure(self):
+        # FAILURE then FAILURE
+        code = textwrap.dedent("""
+            import unittest
+
+            class ExampleTests(unittest.IsolatedAsyncioTestCase):
+                async def asyncTearDown(self):
+                    raise RuntimeError('Fail')
+
+                async def test_success(self):
+                    return
+        """)
+        testname = self.create_test(code=code)
+
+        output = self.run_tests("-w", testname, exitcode=EXITCODE_BAD_TEST)
+        self.check_executed_tests(output, testname,
+                                  failed=[testname],
+                                  rerun={testname: "test_success"})
+
     def test_no_tests_ran(self):
         code = textwrap.dedent("""
             import unittest