diff --git a/Lib/sqlite3/test/regression.py b/Lib/sqlite3/test/regression.py
index 417a53109c87c7..3ddd2f8ec5da5a 100644
--- a/Lib/sqlite3/test/regression.py
+++ b/Lib/sqlite3/test/regression.py
@@ -414,6 +414,33 @@ def test_return_empty_bytestring(self):
         val = cur.fetchone()[0]
         self.assertEqual(val, b'')
 
+    def test_uninitialized_isolation_level(self):
+        """
+        Previously trying to get the isolation level of an uninitialized Connection
+        caused a segfault, now it should just return None.
+        """
+        conn = sqlite.Connection.__new__(sqlite.Connection)
+        with self.assertRaises(sqlite.ProgrammingError):
+            conn.isolation_level
+
+    def test_cursor_invalid_isolation_level(self):
+        """
+        When trying to call conn.cursor() when conn is a Connection object that
+        was not initialized properly, it caused a segfault. Now it should raise
+        a ProgrammingError.
+        """
+        conn = sqlite.Connection.__new__(sqlite.Connection)
+        self.assertRaises(ValueError, conn.__init__, '', isolation_level='invalid isolation level')
+        self.assertRaises(sqlite.ProgrammingError, conn.cursor)
+
+
+    def test_close_invalid_connection(self):
+        """
+        Trying to call close() on a connection which was not initialized properly,
+        it caused a segfault. Now it should raise a ProgrammingError.
+        """
+        conn = sqlite.Connection.__new__(sqlite.Connection)
+        self.assertRaises(sqlite.ProgrammingError, conn.close)
 
 def suite():
     tests = [
diff --git a/Modules/_sqlite/connection.c b/Modules/_sqlite/connection.c
index 5f8e41b6169a76..b52d1819a903c2 100644
--- a/Modules/_sqlite/connection.c
+++ b/Modules/_sqlite/connection.c
@@ -118,11 +118,15 @@ pysqlite_connection_init(pysqlite_Connection *self, PyObject *args,
     if (!isolation_level) {
         isolation_level = PyUnicode_FromString("");
         if (!isolation_level) {
+            PyErr_SetString(pysqlite_ProgrammingError, "Isolation level could not be set.");
             return -1;
         }
     } else {
         Py_INCREF(isolation_level);
     }
+    
+    self->initialized = 1;
+    
     Py_CLEAR(self->isolation_level);
     if (pysqlite_connection_set_isolation_level(self, isolation_level, NULL) < 0) {
         Py_DECREF(isolation_level);
@@ -250,8 +254,19 @@ pysqlite_connection_dealloc(pysqlite_Connection *self)
  */
 int pysqlite_connection_register_cursor(pysqlite_Connection* connection, PyObject* cursor)
 {
+    if (!connection || !connection->cursors) {
+        PyErr_Format(pysqlite_ProgrammingError,
+                     "Base Connection.__init__ not called.");
+        goto error;
+    }
     PyObject* weakref;
 
+    if (!connection->cursors) {
+        PyErr_SetString(pysqlite_ProgrammingError,
+                        "Base Connection.__init__ not called.");
+        goto error;
+    }
+
     weakref = PyWeakref_NewRef((PyObject*)cursor, NULL);
     if (!weakref) {
         goto error;
@@ -281,6 +296,11 @@ static PyObject *
 pysqlite_connection_cursor_impl(pysqlite_Connection *self, PyObject *factory)
 /*[clinic end generated code: output=562432a9e6af2aa1 input=4127345aa091b650]*/
 {
+    if (self == NULL) {
+        return NULL;
+    }
+        
+    static char *kwlist[] = {"factory", NULL};
     PyObject* cursor;
 
     if (!pysqlite_check_thread(self) || !pysqlite_check_connection(self)) {
@@ -323,6 +343,12 @@ pysqlite_connection_close_impl(pysqlite_Connection *self)
 /*[clinic end generated code: output=a546a0da212c9b97 input=3d58064bbffaa3d3]*/
 {
     int rc;
+    
+    if (!self->statements) {
+        PyErr_SetString(pysqlite_ProgrammingError,
+                        "Base Connection.__init__ not called.");
+        return NULL;
+    }
 
     if (!pysqlite_check_thread(self)) {
         return NULL;
@@ -1225,6 +1251,11 @@ int pysqlite_check_thread(pysqlite_Connection* self)
 
 static PyObject* pysqlite_connection_get_isolation_level(pysqlite_Connection* self, void* unused)
 {
+    if (!self || !self->isolation_level) {
+        PyErr_Format(pysqlite_ProgrammingError,
+                    "Object is null or isolation_level is uninitialized.");
+        return 0;
+    }
     return Py_NewRef(self->isolation_level);
 }