diff --git a/Lib/distutils/tests/test_sysconfig.py b/Lib/distutils/tests/test_sysconfig.py
index e7d435f412db79..0664acade82cd1 100644
--- a/Lib/distutils/tests/test_sysconfig.py
+++ b/Lib/distutils/tests/test_sysconfig.py
@@ -10,7 +10,7 @@
 from distutils import sysconfig
 from distutils.ccompiler import get_default_compiler
 from distutils.tests import support
-from test.support import run_unittest, swap_item, requires_subprocess
+from test.support import run_unittest, swap_item, requires_subprocess, is_wasi
 from test.support.os_helper import TESTFN
 from test.support.warnings_helper import check_warnings
 
@@ -32,6 +32,7 @@ def cleanup_testfn(self):
         elif os.path.isdir(TESTFN):
             shutil.rmtree(TESTFN)
 
+    @unittest.skipIf(is_wasi, "Incompatible with WASI mapdir and OOT builds")
     def test_get_config_h_filename(self):
         config_h = sysconfig.get_config_h_filename()
         self.assertTrue(os.path.isfile(config_h), config_h)
diff --git a/Lib/test/test_sysconfig.py b/Lib/test/test_sysconfig.py
index f2b93706b270a7..1679700f59296f 100644
--- a/Lib/test/test_sysconfig.py
+++ b/Lib/test/test_sysconfig.py
@@ -5,7 +5,9 @@
 import shutil
 from copy import copy
 
-from test.support import (captured_stdout, PythonSymlink, requires_subprocess)
+from test.support import (
+    captured_stdout, PythonSymlink, requires_subprocess, is_wasi
+)
 from test.support.import_helper import import_module
 from test.support.os_helper import (TESTFN, unlink, skip_unless_symlink,
                                     change_cwd)
@@ -328,6 +330,7 @@ def test_get_platform(self):
 
         # XXX more platforms to tests here
 
+    @unittest.skipIf(is_wasi, "Incompatible with WASI mapdir and OOT builds")
     def test_get_config_h_filename(self):
         config_h = sysconfig.get_config_h_filename()
         self.assertTrue(os.path.isfile(config_h), config_h)
@@ -499,6 +502,7 @@ class MakefileTests(unittest.TestCase):
 
     @unittest.skipIf(sys.platform.startswith('win'),
                      'Test is not Windows compatible')
+    @unittest.skipIf(is_wasi, "Incompatible with WASI mapdir and OOT builds")
     def test_get_makefile_filename(self):
         makefile = sysconfig.get_makefile_filename()
         self.assertTrue(os.path.isfile(makefile), makefile)