diff --git a/Include/pymacro.h b/Include/pymacro.h
index 0a2c342e2c8aee..e37cda44c5ebf1 100644
--- a/Include/pymacro.h
+++ b/Include/pymacro.h
@@ -12,8 +12,10 @@
 
 // static_assert is defined in glibc from version 2.16. Before it requires
 // compiler support (gcc >= 4.6) and is called _Static_assert.
+// In C++ 11 static_assert is a keyword, redefining is undefined behaviour.
 #if (defined(__GLIBC__) \
      && (__GLIBC__ < 2 || (__GLIBC__ == 2 && __GLIBC_MINOR__ <= 16)) \
+     && !(defined(__cplusplus) && __cplusplus >= 201103L) \
      && !defined(static_assert))
 #  define static_assert _Static_assert
 #endif
diff --git a/Misc/NEWS.d/next/C API/2022-06-10-23-41-48.gh-issue-91731.fhYUQG.rst b/Misc/NEWS.d/next/C API/2022-06-10-23-41-48.gh-issue-91731.fhYUQG.rst
new file mode 100644
index 00000000000000..185671ca4fcfb1
--- /dev/null
+++ b/Misc/NEWS.d/next/C API/2022-06-10-23-41-48.gh-issue-91731.fhYUQG.rst	
@@ -0,0 +1,3 @@
+Avoid defining the ``static_assert`` when compiling with C++ 11, where this
+is a keyword and redefining it can lead to undefined behavior. Patch by
+Pablo Galindo