diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-06-17-16-30-24.gh-issue-93955.LmiAe9.rst b/Misc/NEWS.d/next/Core and Builtins/2022-06-17-16-30-24.gh-issue-93955.LmiAe9.rst
new file mode 100644
index 00000000000000..3b2f0e8c32d745
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-06-17-16-30-24.gh-issue-93955.LmiAe9.rst	
@@ -0,0 +1 @@
+Improve performance of attribute lookups on objects with custom ``__getattribute__`` and ``__getattr__``. Patch by Ken Jin.
diff --git a/Objects/typeobject.c b/Objects/typeobject.c
index db4682c69ed0e3..513055168062f1 100644
--- a/Objects/typeobject.c
+++ b/Objects/typeobject.c
@@ -7782,10 +7782,17 @@ slot_tp_getattro(PyObject *self, PyObject *name)
     return vectorcall_method(&_Py_ID(__getattribute__), stack, 2);
 }
 
-static PyObject *
+static inline PyObject *
 call_attribute(PyObject *self, PyObject *attr, PyObject *name)
 {
     PyObject *res, *descr = NULL;
+
+    if (_PyType_HasFeature(Py_TYPE(attr), Py_TPFLAGS_METHOD_DESCRIPTOR)) {
+        PyObject *args[] = { self, name };
+        res = PyObject_Vectorcall(attr, args, 2, NULL);
+        return res;
+    }
+
     descrgetfunc f = Py_TYPE(attr)->tp_descr_get;
 
     if (f != NULL) {