diff --git a/mypy/messages.py b/mypy/messages.py
index 086f3d22aee1..8499e5eceee3 100644
--- a/mypy/messages.py
+++ b/mypy/messages.py
@@ -1740,7 +1740,10 @@ def format(typ: Type) -> str:
             # return type (this always works).
             return format(TypeType.make_normalized(erase_type(func.items[0].ret_type)))
         elif isinstance(func, CallableType):
-            return_type = format(func.ret_type)
+            if func.type_guard is not None:
+                return_type = f'TypeGuard[{format(func.type_guard)}]'
+            else:
+                return_type = format(func.ret_type)
             if func.is_ellipsis_args:
                 return 'Callable[..., {}]'.format(return_type)
             arg_strings = []
diff --git a/mypy/subtypes.py b/mypy/subtypes.py
index 52d03282494f..8f804481104f 100644
--- a/mypy/subtypes.py
+++ b/mypy/subtypes.py
@@ -310,6 +310,13 @@ def visit_type_var(self, left: TypeVarType) -> bool:
     def visit_callable_type(self, left: CallableType) -> bool:
         right = self.right
         if isinstance(right, CallableType):
+            if left.type_guard is not None and right.type_guard is not None:
+                if not self._is_subtype(left.type_guard, right.type_guard):
+                    return False
+            elif right.type_guard is not None and left.type_guard is None:
+                # This means that one function has `TypeGuard` and other does not.
+                # They are not compatible. See https://github.com/python/mypy/issues/11307
+                return False
             return is_callable_compatible(
                 left, right,
                 is_compat=self._is_subtype,
diff --git a/test-data/unit/check-typeguard.test b/test-data/unit/check-typeguard.test
index fb26f0d3d537..6dae011b59ce 100644
--- a/test-data/unit/check-typeguard.test
+++ b/test-data/unit/check-typeguard.test
@@ -458,3 +458,92 @@ def foobar_typeguard(x: object):
         return
     reveal_type(x)  # N: Revealed type is "__main__.<subclass of "Foo" and "Bar">"
 [builtins fixtures/tuple.pyi]
+
+[case testTypeGuardAsFunctionArgAsBoolSubtype]
+from typing import Callable
+from typing_extensions import TypeGuard
+
+def accepts_bool(f: Callable[[object], bool]): pass
+
+def with_bool_typeguard(o: object) -> TypeGuard[bool]: pass
+def with_str_typeguard(o: object) -> TypeGuard[str]: pass
+def with_bool(o: object) -> bool: pass
+
+accepts_bool(with_bool_typeguard)
+accepts_bool(with_str_typeguard)
+accepts_bool(with_bool)
+[builtins fixtures/tuple.pyi]
+
+[case testTypeGuardAsFunctionArg]
+from typing import Callable
+from typing_extensions import TypeGuard
+
+def accepts_typeguard(f: Callable[[object], TypeGuard[bool]]): pass
+def different_typeguard(f: Callable[[object], TypeGuard[str]]): pass
+
+def with_typeguard(o: object) -> TypeGuard[bool]: pass
+def with_bool(o: object) -> bool: pass
+
+accepts_typeguard(with_typeguard)
+accepts_typeguard(with_bool)  # E: Argument 1 to "accepts_typeguard" has incompatible type "Callable[[object], bool]"; expected "Callable[[object], TypeGuard[bool]]"
+
+different_typeguard(with_typeguard)  # E: Argument 1 to "different_typeguard" has incompatible type "Callable[[object], TypeGuard[bool]]"; expected "Callable[[object], TypeGuard[str]]"
+different_typeguard(with_bool)  # E: Argument 1 to "different_typeguard" has incompatible type "Callable[[object], bool]"; expected "Callable[[object], TypeGuard[str]]"
+[builtins fixtures/tuple.pyi]
+
+[case testTypeGuardAsGenericFunctionArg]
+from typing import Callable, TypeVar
+from typing_extensions import TypeGuard
+
+T = TypeVar('T')
+
+def accepts_typeguard(f: Callable[[object], TypeGuard[T]]): pass
+
+def with_bool_typeguard(o: object) -> TypeGuard[bool]: pass
+def with_str_typeguard(o: object) -> TypeGuard[str]: pass
+def with_bool(o: object) -> bool: pass
+
+accepts_typeguard(with_bool_typeguard)
+accepts_typeguard(with_str_typeguard)
+accepts_typeguard(with_bool)  # E: Argument 1 to "accepts_typeguard" has incompatible type "Callable[[object], bool]"; expected "Callable[[object], TypeGuard[bool]]"
+[builtins fixtures/tuple.pyi]
+
+[case testTypeGuardAsOverloadedFunctionArg]
+# https://github.com/python/mypy/issues/11307
+from typing import Callable, TypeVar, Generic, Any, overload
+from typing_extensions import TypeGuard
+
+_T = TypeVar('_T')
+
+class filter(Generic[_T]):
+    @overload
+    def __init__(self, function: Callable[[object], TypeGuard[_T]]) -> None: pass
+    @overload
+    def __init__(self, function: Callable[[_T], Any]) -> None: pass
+    def __init__(self, function): pass
+
+def is_int_typeguard(a: object) -> TypeGuard[int]: pass
+def returns_bool(a: object) -> bool: pass
+
+reveal_type(filter(is_int_typeguard))  # N: Revealed type is "__main__.filter[builtins.int*]"
+reveal_type(filter(returns_bool))  # N: Revealed type is "__main__.filter[builtins.object*]"
+[builtins fixtures/tuple.pyi]
+
+[case testTypeGuardSubtypingVariance]
+from typing import Callable
+from typing_extensions import TypeGuard
+
+class A: pass
+class B(A): pass
+class C(B): pass
+
+def accepts_typeguard(f: Callable[[object], TypeGuard[B]]): pass
+
+def with_typeguard_a(o: object) -> TypeGuard[A]: pass
+def with_typeguard_b(o: object) -> TypeGuard[B]: pass
+def with_typeguard_c(o: object) -> TypeGuard[C]: pass
+
+accepts_typeguard(with_typeguard_a)  # E: Argument 1 to "accepts_typeguard" has incompatible type "Callable[[object], TypeGuard[A]]"; expected "Callable[[object], TypeGuard[B]]"
+accepts_typeguard(with_typeguard_b)
+accepts_typeguard(with_typeguard_c)
+[builtins fixtures/tuple.pyi]