diff --git a/mypy/semanal.py b/mypy/semanal.py
index 7f8c5754ff2f..350f3717d3a1 100644
--- a/mypy/semanal.py
+++ b/mypy/semanal.py
@@ -817,8 +817,8 @@ def analyze_class_body(self, defn: ClassDef) -> Iterator[bool]:
             else:
                 self.setup_class_def_analysis(defn)
                 self.analyze_base_classes(defn)
-                self.analyze_metaclass(defn)
                 defn.info.is_protocol = is_protocol
+                self.analyze_metaclass(defn)
                 defn.info.runtime_protocol = False
                 for decorator in defn.decorators:
                     self.analyze_class_decorator(defn, decorator)
@@ -1339,6 +1339,14 @@ def analyze_metaclass(self, defn: ClassDef) -> None:
             assert isinstance(inst, Instance)
             defn.info.declared_metaclass = inst
         defn.info.metaclass_type = defn.info.calculate_metaclass_type()
+        if any(info.is_protocol for info in defn.info.mro):
+            if (not defn.info.metaclass_type or
+                    defn.info.metaclass_type.type.fullname() == 'builtins.type'):
+                # All protocols and their subclasses have ABCMeta metaclass by default.
+                # TODO: add a metaclass conflict check if there is another metaclass.
+                abc_meta = self.named_type_or_none('abc.ABCMeta', [])
+                if abc_meta is not None:  # May be None in tests with incomplete lib-stub.
+                    defn.info.metaclass_type = abc_meta
         if defn.info.metaclass_type is None:
             # Inconsistency may happen due to multiple baseclasses even in classes that
             # do not declare explicit metaclass, but it's harder to catch at this stage
diff --git a/test-data/unit/check-protocols.test b/test-data/unit/check-protocols.test
index 935824afbc5b..769d2566fa96 100644
--- a/test-data/unit/check-protocols.test
+++ b/test-data/unit/check-protocols.test
@@ -2395,3 +2395,13 @@ reveal_type([a, b])  # E: Revealed type is 'builtins.list[def (x: def (__main__.
 reveal_type([b, a])  # E: Revealed type is 'builtins.list[def (x: def (__main__.B) -> __main__.B)]'
 [builtins fixtures/list.pyi]
 [out]
+
+[case testProtocolsAlwaysABCs]
+from typing import Protocol
+
+class P(Protocol): ...
+class C(P): ...
+
+reveal_type(C.register(int))  # E: Revealed type is 'def () -> builtins.int'
+[typing fixtures/typing-full.pyi]
+[out]
diff --git a/test-data/unit/check-serialize.test b/test-data/unit/check-serialize.test
index 028dc6847d09..70dc873083e9 100644
--- a/test-data/unit/check-serialize.test
+++ b/test-data/unit/check-serialize.test
@@ -378,6 +378,7 @@ class A(metaclass=ABCMeta):
     def f(self) -> None: pass
     @abstractproperty
     def x(self) -> int: return 0
+[typing fixtures/typing-full.pyi]
 [out2]
 tmp/a.py:2: error: Cannot instantiate abstract class 'A' with abstract attributes 'f' and 'x'
 tmp/a.py:9: error: Property "x" defined in "A" is read-only
diff --git a/test-data/unit/lib-stub/abc.pyi b/test-data/unit/lib-stub/abc.pyi
index 9208f42e9635..0b1a51c78f5c 100644
--- a/test-data/unit/lib-stub/abc.pyi
+++ b/test-data/unit/lib-stub/abc.pyi
@@ -1,3 +1,8 @@
-class ABCMeta(type): pass
+from typing import Type, Any, TypeVar
+
+T = TypeVar('T', bound=Type[Any])
+
+class ABCMeta(type):
+    def register(cls, tp: T) -> T: pass
 abstractmethod = object()
 abstractproperty = object()
diff --git a/test-data/unit/lib-stub/typing.pyi b/test-data/unit/lib-stub/typing.pyi
index 0aa899e5095b..157f3a2ca798 100644
--- a/test-data/unit/lib-stub/typing.pyi
+++ b/test-data/unit/lib-stub/typing.pyi
@@ -8,7 +8,7 @@ Union = 0
 Optional = 0
 TypeVar = 0
 Generic = 0
-Protocol = 0  # This is not yet defined in typeshed, see PR typeshed/#1220
+Protocol = 0
 Tuple = 0
 Callable = 0
 NamedTuple = 0