diff --git a/mypy/checkexpr.py b/mypy/checkexpr.py
index cc563cf562af..235a9f44c2c5 100644
--- a/mypy/checkexpr.py
+++ b/mypy/checkexpr.py
@@ -986,6 +986,9 @@ def visit_index_expr_helper(self, e: IndexExpr) -> Type:
             # Special case for tuples. They support indexing only by integer
             # literals.  (Except in weak type checking mode.)
             index = e.index
+            if isinstance(index, SliceExpr):
+                return self.visit_tuple_slice_helper(left_type, index)
+
             ok = False
             if isinstance(index, IntExpr):
                 n = index.value
@@ -1010,6 +1013,32 @@ def visit_index_expr_helper(self, e: IndexExpr) -> Type:
             e.method_type = method_type
             return result
 
+    def visit_tuple_slice_helper(self, left_type: TupleType, slic: SliceExpr):
+        begin = 0
+        end = len(left_type.items)
+        stride = 1
+        if slic.begin_index:
+            if isinstance(slic.begin_index, IntExpr):
+                begin = slic.begin_index.value
+            else:
+                self.chk.fail(messages.TUPLE_SLICE_MUST_BE_AN_INT_LITERAL, slic.begin_index)
+                return AnyType()
+        if slic.end_index:
+            if isinstance(slic.end_index, IntExpr):
+                end = slic.end_index.value
+            else:
+                self.chk.fail(messages.TUPLE_SLICE_MUST_BE_AN_INT_LITERAL, slic.end_index)
+                return AnyType()
+        if slic.stride:
+            if isinstance(slic.stride, IntExpr):
+                stride = slic.stride.value
+            else:
+                self.chk.fail(messages.TUPLE_SLICE_MUST_BE_AN_INT_LITERAL, slic.stride)
+                return AnyType()
+
+        return TupleType(left_type.items[begin:end:stride], left_type.fallback,
+                    left_type.line, left_type.implicit)
+
     def visit_cast_expr(self, expr: CastExpr) -> Type:
         """Type check a cast expression."""
         source_type = self.accept(expr.expr, context=AnyType())
diff --git a/mypy/messages.py b/mypy/messages.py
index 40e040393cf8..93b537bca761 100644
--- a/mypy/messages.py
+++ b/mypy/messages.py
@@ -41,7 +41,8 @@
 INIT_MUST_HAVE_NONE_RETURN_TYPE = 'The return type of "__init__" must be None'
 GETTER_TYPE_INCOMPATIBLE_WITH_SETTER = \
     'Type of getter incompatible with setter'
-TUPLE_INDEX_MUST_BE_AN_INT_LITERAL = 'Tuple index must an integer literal'
+TUPLE_INDEX_MUST_BE_AN_INT_LITERAL = 'Tuple index must be an integer literal'
+TUPLE_SLICE_MUST_BE_AN_INT_LITERAL = 'Tuple slice must be an integer literal'
 TUPLE_INDEX_OUT_OF_RANGE = 'Tuple index out of range'
 TYPE_CONSTANT_EXPECTED = 'Type "Constant" or initializer expected'
 INCOMPATIBLE_PAIR_ITEM_TYPE = 'Incompatible Pair item type'
diff --git a/mypy/test/data/check-tuples.test b/mypy/test/data/check-tuples.test
index 07586cfb4916..d8f580e330da 100644
--- a/mypy/test/data/check-tuples.test
+++ b/mypy/test/data/check-tuples.test
@@ -152,7 +152,10 @@ def f() -> None: pass
 from typing import Tuple
 t1 = None # type: Tuple[A, B]
 t2 = None # type: Tuple[A]
+t3 = None # type: Tuple[A, B, C, D, E]
 a, b = None, None # type: (A, B)
+x = None # type: Tuple[A, B, C]
+y = None # type: Tuple[A, C, E]
 n = 0
 
 a = t1[1] # E: Incompatible types in assignment (expression has type "B", variable has type "A")
@@ -160,15 +163,21 @@ b = t1[0] # E: Incompatible types in assignment (expression has type "A", variab
 t1[2]     # E: Tuple index out of range
 t1[3]     # E: Tuple index out of range
 t2[1]     # E: Tuple index out of range
-t1[n]     # E: Tuple index must an integer literal
+t1[n]     # E: Tuple index must be an integer literal
+t3[n:]    # E: Tuple slice must be an integer literal
 b = t1[(0)] # E: Incompatible types in assignment (expression has type "A", variable has type "B")
 
 a = t1[0]
 b = t1[1]
 a = t1[(0)]
+x = t3[0:3] # type (A, B, C)
+y = t3[0:5:2] # type (A, C, E)
 
 class A: pass
 class B: pass
+class C: pass
+class D: pass
+class E: pass
 [builtins fixtures/tuple.py]
 
 [case testIndexingTuplesWithNegativeIntegers]