diff --git a/extensions/resteasy-reactive/rest/deployment/src/main/java/io/quarkus/resteasy/reactive/server/deployment/ResteasyReactiveProcessor.java b/extensions/resteasy-reactive/rest/deployment/src/main/java/io/quarkus/resteasy/reactive/server/deployment/ResteasyReactiveProcessor.java
index d9fe9f478b498..67adec4015f7f 100644
--- a/extensions/resteasy-reactive/rest/deployment/src/main/java/io/quarkus/resteasy/reactive/server/deployment/ResteasyReactiveProcessor.java
+++ b/extensions/resteasy-reactive/rest/deployment/src/main/java/io/quarkus/resteasy/reactive/server/deployment/ResteasyReactiveProcessor.java
@@ -245,6 +245,8 @@ public class ResteasyReactiveProcessor {
     private static final int SECURITY_EXCEPTION_MAPPERS_PRIORITY = Priorities.USER + 1;
     private static final String[] EMPTY_STRING_ARRAY = new String[0];
 
+    private static final DotName QUARKUS_TEST_MOCK = DotName.createSimple("io.quarkus.test.Mock");
+
     @BuildStep
     public FeatureBuildItem buildSetup() {
         return new FeatureBuildItem(Feature.REST);
@@ -697,21 +699,23 @@ public Supplier<Boolean> apply(ClassInfo classInfo) {
                     generatedClassBuildItemBuildProducer, applicationClassPredicate, reflectiveClassBuildItemBuildProducer));
             serverEndpointIndexer = serverEndpointIndexerBuilder.build();
 
-            Map<String, List<EndpointConfig>> allMethods = new HashMap<>();
-            for (ClassInfo i : scannedResources.values()) {
-                Optional<ResourceClass> endpoints = serverEndpointIndexer.createEndpoints(i, true);
+            Map<String, List<EndpointConfig>> allServerMethods = new HashMap<>();
+            for (ClassInfo ci : scannedResources.values()) {
+                Optional<ResourceClass> endpoints = serverEndpointIndexer.createEndpoints(ci, true);
                 if (endpoints.isPresent()) {
-                    if (singletonClasses.contains(i.name().toString())) {
-                        endpoints.get().setFactory(new SingletonBeanFactory<>(i.name().toString()));
+                    if (singletonClasses.contains(ci.name().toString())) {
+                        endpoints.get().setFactory(new SingletonBeanFactory<>(ci.name().toString()));
                     }
                     resourceClasses.add(endpoints.get());
-                    for (ResourceMethod rm : endpoints.get().getMethods()) {
-                        addResourceMethodByPath(allMethods, endpoints.get().getPath(), i, rm);
+                    if (!ignoreResourceForDuplicateDetection(ci)) {
+                        for (ResourceMethod rm : endpoints.get().getMethods()) {
+                            addResourceMethodByPath(allServerMethods, endpoints.get().getPath(), ci, rm);
+                        }
                     }
                 }
             }
 
-            checkForDuplicateEndpoint(config, allMethods);
+            checkForDuplicateEndpoint(config, allServerMethods);
 
             //now index possible sub resources. These are all classes that have method annotations
             //that are not annotated @Path
@@ -782,6 +786,14 @@ public Supplier<Boolean> apply(ClassInfo classInfo) {
         handleDateFormatReflection(reflectiveClassBuildItemBuildProducer, index);
     }
 
+    // TODO: this is really just a hackish way of allowing the use of @Mock so we might need something better
+    private boolean ignoreResourceForDuplicateDetection(ClassInfo ci) {
+        if (ci.hasAnnotation(QUARKUS_TEST_MOCK)) {
+            return true;
+        }
+        return false;
+    }
+
     private boolean filtersAccessResourceMethod(ResourceInterceptors resourceInterceptors) {
         AtomicBoolean ab = new AtomicBoolean(false);
         ResourceInterceptors.FiltersVisitor visitor = new ResourceInterceptors.FiltersVisitor() {
diff --git a/extensions/resteasy-reactive/rest/deployment/src/test/java/io/quarkus/resteasy/reactive/server/test/duplicate/DuplicateResourceAndClientTest.java b/extensions/resteasy-reactive/rest/deployment/src/test/java/io/quarkus/resteasy/reactive/server/test/duplicate/DuplicateResourceAndClientTest.java
new file mode 100644
index 0000000000000..69fdd14033620
--- /dev/null
+++ b/extensions/resteasy-reactive/rest/deployment/src/test/java/io/quarkus/resteasy/reactive/server/test/duplicate/DuplicateResourceAndClientTest.java
@@ -0,0 +1,59 @@
+package io.quarkus.resteasy.reactive.server.test.duplicate;
+
+import static io.restassured.RestAssured.when;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.Produces;
+import jakarta.ws.rs.core.MediaType;
+
+import org.jboss.shrinkwrap.api.ShrinkWrap;
+import org.jboss.shrinkwrap.api.spec.JavaArchive;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.test.Mock;
+import io.quarkus.test.QuarkusUnitTest;
+
+public class DuplicateResourceAndClientTest {
+
+    @RegisterExtension
+    static QuarkusUnitTest runner = new QuarkusUnitTest()
+            .setArchiveProducer(() -> ShrinkWrap.create(JavaArchive.class)
+                    .addClasses(Client.class, Resource.class));
+
+    @Test
+    public void dummy() {
+        when()
+                .get("/hello")
+                .then()
+                .statusCode(200);
+    }
+
+    @Path("/hello")
+    public interface Client {
+
+        @GET
+        @Produces(MediaType.TEXT_PLAIN)
+        String hello();
+    }
+
+    @Mock
+    public static class ClientMock implements Client {
+
+        @Override
+        public String hello() {
+            return "";
+        }
+    }
+
+    @Path("/hello")
+    public static class Resource {
+
+        @GET
+        @Produces(MediaType.TEXT_PLAIN)
+        public String hello() {
+            return "hello";
+        }
+    }
+}