diff --git a/.changeset/wicked-birds-suffer.md b/.changeset/wicked-birds-suffer.md
new file mode 100644
index 0000000000..a592030d3e
--- /dev/null
+++ b/.changeset/wicked-birds-suffer.md
@@ -0,0 +1,5 @@
+---
+"@react-router/dev": patch
+---
+
+Reinstate dependency optimization in the child compiler to fix `depsOptimizer is required in dev mode` errors when using `vite-plugin-cloudflare` and importing Node.js builtins
diff --git a/packages/react-router-dev/vite/plugin.ts b/packages/react-router-dev/vite/plugin.ts
index 9f4fb59c1f..e4a6f29204 100644
--- a/packages/react-router-dev/vite/plugin.ts
+++ b/packages/react-router-dev/vite/plugin.ts
@@ -1445,26 +1445,6 @@ export const reactRouterVitePlugin: ReactRouterVitePlugin = () => {
                 configureServer: undefined,
                 configurePreviewServer: undefined,
               })),
-            {
-              name: "react-router:override-optimize-deps",
-              config(userConfig) {
-                // Prevent unnecessary dependency optimization in the child compiler
-                if (
-                  ctx.reactRouterConfig.future.unstable_viteEnvironmentApi &&
-                  userConfig.environments
-                ) {
-                  for (const environmentName of Object.keys(
-                    userConfig.environments
-                  )) {
-                    userConfig.environments[environmentName].optimizeDeps = {
-                      noDiscovery: true,
-                    };
-                  }
-                } else {
-                  userConfig.optimizeDeps = { noDiscovery: true };
-                }
-              },
-            },
           ],
         });
         await viteChildCompiler.pluginContainer.buildStart({});