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USP Drug Classifications

Data files (available at data.world)

  • Raw text: br08302.keg
  • Tidy CSV: usp_drug_classification.csv

Link(s) to code used for scraping, tidying, etc, if applicable:

Data was directly downloaded from KEGG, (click on Download htext in the upper left-hand corner) no scraping needed.

  • Tidying script: usp_drug_classification_tidying_script.py

Data types

  • string: a sequence of characters

Field listing

Name Type Description
usp_category string USP Category
usp_class string USP Class
usp_drug string The general drug (e.g. Naproxen, Ibuprofen, etc)
drug_example string The specific drug (e.g. Naproxen sodium, Ibuprofen arginine salt, etc)
kegg_id_drug string The KEGG identifier for the usp_drug (e.g. DG00245)
kegg_id_drug_example string The KEGG identifier for the drug_example (e.g. D01122)
nomenclature string (Unparsed) nomenclature description (e.g. '(JP17/USP/INN)')

Important notes

Background

From the US Pharmacopeial Convention's website: the USP Drug Classification system (USP DC) is an independent drug classification system currently under development by the USP Healthcare Quality Expert Committee. The USP DC is designed to address stakeholder needs emerging from the extended use of the USP Medicare Model Guidelines (USP MMG) beyond the Medicare Part D benefit.

The USP DC is intended to be complementary to the USP MMG and is developed with similar guiding principles, taxonomy, and structure of the USP Categories and Classes.

Raw data

The raw data was downloaded from the KEGG website: http://www.genome.jp/kegg-bin/get_htext?htext=br08302.keg

br08302.keg is a text file with the hierarchical USP drug classifications. Lines beginning with A are USP Categories, subsequent lines beginning with B are USP Classes in that category, lines beginning with C are the drugs (i.e. the general drug compound), and lines beginning with D are example_drugs (i.e. the medication or formulation you would buy) of that drug.

Interpreting the fields

According to the [guidelines](http://www.usp.org/sites/default/files/usp_pdf/EN/healthcareProfessionals/2016_usp_mmg_guiding_pri\ nciples.pdf), a USP Category is the broadest classification which provides a high level formulary structure designed to include all potential therapeutic agents for diseases and conditions. A USP Class is a more granular classification, occurring within a specific USP Category in the USP Drug Classifications, which provides for therapeutic or pharmacologic groupings of FDA approved medications, consistent with current U.S. healthcare practices and standards of care.

From what I understand, the nomenclature string indicates to which official nomenclature system that name belongs to. For example, "a British Approved Name (BAN) is the official non-proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia (BP)" whereas "United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States."

I'm not sure of the best way to store this information (or how useful it will be), so for now the nomunclature strings are in the tidy data unparsed.

Other notes

  • TBD whether this data includes medications covered by Part D Medicare or if it is only complementary to that data.

  • Note that the individual KEGG pages (e.g. D00903) for these drugs have a wealth of information, including product and generic names, chemical formula, additional classes, ATC codes, biochemical information, other classifications, and links to the compound in other databases (e.g. PubChem, DrugBank, etc).