diff --git a/changelog/new_make_minitest_refute_equal_aware_of_assert_operator_and_refute_operator.md b/changelog/new_make_minitest_refute_equal_aware_of_assert_operator_and_refute_operator.md
new file mode 100644
index 0000000..1565ab9
--- /dev/null
+++ b/changelog/new_make_minitest_refute_equal_aware_of_assert_operator_and_refute_operator.md
@@ -0,0 +1 @@
+* [#267](https://github.com/rubocop/rubocop-minitest/pull/267): Make `Minitest/RefuteEqual` aware of `assert_operator` and `refute_operator`. ([@koic][])
diff --git a/lib/rubocop/cop/minitest/refute_equal.rb b/lib/rubocop/cop/minitest/refute_equal.rb
index c3079a7..bbacf8f 100644
--- a/lib/rubocop/cop/minitest/refute_equal.rb
+++ b/lib/rubocop/cop/minitest/refute_equal.rb
@@ -10,6 +10,8 @@ module Minitest
       #   # bad
       #   assert("rubocop-minitest" != actual)
       #   refute("rubocop-minitest" == actual)
+      #   assert_operator("rubocop-minitest", :!=, actual)
+      #   refute_operator("rubocop-minitest", :==, actual)
       #
       #   # good
       #   refute_equal("rubocop-minitest", actual)
@@ -19,48 +21,38 @@ class RefuteEqual < Base
         extend AutoCorrector
 
         MSG = 'Prefer using `refute_equal(%<preferred>s)`.'
-        RESTRICT_ON_SEND = %i[assert refute].freeze
+        RESTRICT_ON_SEND = %i[assert refute assert_operator refute_operator].freeze
 
-        def_node_matcher :assert_not_equal_or_refute_equal, <<~PATTERN
+        def_node_matcher :refute_equal, <<~PATTERN
           {
             (send nil? :assert (send $_ :!= $_) $...)
             (send nil? :refute (send $_ :== $_) $...)
+            (send nil? :assert_operator $_ (sym :!=) $_ $...)
+            (send nil? :refute_operator $_ (sym :==) $_ $...)
           }
         PATTERN
 
+        # rubocop:disable Metrics/AbcSize
         def on_send(node)
-          preferred = process_not_equal(node)
-          return unless preferred
-
-          assert_not_equal_or_refute_equal(node) do |expected, actual|
+          refute_equal(node) do |expected, actual, rest_args|
+            basic_arguments = "#{expected.source}, #{actual.source}"
+            preferred = (message_arg = rest_args.first) ? "#{basic_arguments}, #{message_arg.source}" : basic_arguments
             message = format(MSG, preferred: preferred)
 
             add_offense(node, message: message) do |corrector|
               corrector.replace(node.loc.selector, 'refute_equal')
 
-              replacement = [expected, actual].map(&:source).join(', ')
-              corrector.replace(node.first_argument, replacement)
-            end
-          end
-        end
-
-        private
+              range = if node.method?(:assert) || node.method?(:refute)
+                        node.first_argument
+                      else
+                        node.first_argument.source_range.begin.join(node.arguments[2].source_range.end)
+                      end
 
-        def preferred_usage(first_arg, second_arg, custom_message = nil)
-          [first_arg, second_arg, custom_message].compact.map(&:source).join(', ')
-        end
-
-        def original_usage(first_part, custom_message)
-          [first_part, custom_message].compact.join(', ')
-        end
-
-        def process_not_equal(node)
-          assert_not_equal_or_refute_equal(node) do |first_arg, second_arg, rest_args|
-            custom_message = rest_args.first
-
-            preferred_usage(first_arg, second_arg, custom_message)
+              corrector.replace(range, basic_arguments)
+            end
           end
         end
+        # rubocop:enable Metrics/AbcSize
       end
     end
   end
diff --git a/test/rubocop/cop/minitest/refute_equal_test.rb b/test/rubocop/cop/minitest/refute_equal_test.rb
index a340bc3..3201231 100644
--- a/test/rubocop/cop/minitest/refute_equal_test.rb
+++ b/test/rubocop/cop/minitest/refute_equal_test.rb
@@ -79,12 +79,50 @@ def test_do_something
     RUBY
   end
 
-  def test_registers_offense_when_using_refute_equal_operator
+  def test_registers_offense_when_using_assert_operator_with_negated_equal_symbol_argument
     assert_offense(<<~RUBY)
       class FooTest < Minitest::Test
         def test_do_something
-          refute('rubocop-minitest' == actual)
-          ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Prefer using `refute_equal('rubocop-minitest', actual)`.
+          assert_operator('rubocop-minitest', :!=, actual)
+          ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Prefer using `refute_equal('rubocop-minitest', actual)`.
+        end
+      end
+    RUBY
+
+    assert_correction(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_equal('rubocop-minitest', actual)
+        end
+      end
+    RUBY
+  end
+
+  def test_registers_offense_when_using_assert_operator_with_negated_equal_symbol_and_message_arguments
+    assert_offense(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_operator('rubocop-minitest', :==, actual, message)
+          ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Prefer using `refute_equal('rubocop-minitest', actual, message)`.
+        end
+      end
+    RUBY
+
+    assert_correction(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_equal('rubocop-minitest', actual, message)
+        end
+      end
+    RUBY
+  end
+
+  def test_registers_offense_when_using_refute_operator_with_equal_symbol_argument
+    assert_offense(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_operator('rubocop-minitest', :==, actual)
+          ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Prefer using `refute_equal('rubocop-minitest', actual)`.
         end
       end
     RUBY
@@ -98,6 +136,25 @@ def test_do_something
     RUBY
   end
 
+  def test_registers_offense_when_using_refute_operator_with_equal_symbol_and_message_arguments
+    assert_offense(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_operator('rubocop-minitest', :==, actual, message)
+          ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Prefer using `refute_equal('rubocop-minitest', actual, message)`.
+        end
+      end
+    RUBY
+
+    assert_correction(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_equal('rubocop-minitest', actual, message)
+        end
+      end
+    RUBY
+  end
+
   def test_does_not_register_offense_when_using_negate_equals
     assert_no_offenses(<<~RUBY)
       class FooTest < Minitest::Test
@@ -140,4 +197,24 @@ def test_do_something
       end
     RUBY
   end
+
+  def test_registers_offense_when_using_assert_operator_with_equal_symbol_argument
+    assert_no_offenses(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          assert_operator('rubocop-minitest', :==, actual)
+        end
+      end
+    RUBY
+  end
+
+  def test_registers_offense_when_using_refute_operator_with_negated_equal_symbol_argument
+    assert_no_offenses(<<~RUBY)
+      class FooTest < Minitest::Test
+        def test_do_something
+          refute_operator('rubocop-minitest', :!=, actual)
+        end
+      end
+    RUBY
+  end
 end