diff --git a/CHANGELOG.md b/CHANGELOG.md
index b15d5e1bba..1cb8209733 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -65,7 +65,7 @@
   - [Fixed](#fixed-13)
 - [0.54.1](#0541)
   - [Added](#added-12)
-  - [Changed](#changed-10)
+  - [Changed](#chainged-10)
   - [Fixed](#fixed-14)
 - [0.54.0](#0540)
   - [Added](#added-13)
@@ -174,6 +174,8 @@
  * Added the `Builder::emit_diagnostics` method and the  `--emit-diagnostics`
    flag to enable emission of diagnostic messages.
  * Added support for the `"efiapi"` calling convention.
+ * Added the `ParseCallbacks::read_env_var` method which runs everytime
+   `bindgen` reads and environment variable.
 
 ## Changed
  * Static functions with no arguments use `void` as their single argument
diff --git a/bindgen/callbacks.rs b/bindgen/callbacks.rs
index d85e565565..582446687c 100644
--- a/bindgen/callbacks.rs
+++ b/bindgen/callbacks.rs
@@ -102,6 +102,10 @@ pub trait ParseCallbacks: fmt::Debug {
     /// This will be called on every file inclusion, with the full path of the included file.
     fn include_file(&self, _filename: &str) {}
 
+    /// This will be called every time `bindgen` reads an environment variable whether it has any
+    /// content or not.
+    fn read_env_var(&self, _key: &str) {}
+
     /// This will be called to determine whether a particular blocklisted type
     /// implements a trait or not. This will be used to implement traits on
     /// other types containing the blocklisted type.
diff --git a/bindgen/lib.rs b/bindgen/lib.rs
index cd0a06c942..5b54f45ad1 100644
--- a/bindgen/lib.rs
+++ b/bindgen/lib.rs
@@ -68,10 +68,12 @@ use parse::ParseError;
 use std::borrow::Cow;
 use std::collections::hash_map::Entry;
 use std::env;
+use std::ffi::OsStr;
 use std::fs::{File, OpenOptions};
 use std::io::{self, Write};
 use std::path::{Path, PathBuf};
 use std::process::{Command, Stdio};
+use std::rc::Rc;
 use std::str::FromStr;
 
 // Some convenient typedefs for a fast hash map and hash set.
@@ -278,13 +280,18 @@ pub fn builder() -> Builder {
     Default::default()
 }
 
-fn get_extra_clang_args() -> Vec<String> {
+fn get_extra_clang_args(
+    parse_callbacks: &[Rc<dyn callbacks::ParseCallbacks>],
+) -> Vec<String> {
     // Add any extra arguments from the environment to the clang command line.
-    let extra_clang_args =
-        match get_target_dependent_env_var("BINDGEN_EXTRA_CLANG_ARGS") {
-            None => return vec![],
-            Some(s) => s,
-        };
+    let extra_clang_args = match get_target_dependent_env_var(
+        parse_callbacks,
+        "BINDGEN_EXTRA_CLANG_ARGS",
+    ) {
+        None => return vec![],
+        Some(s) => s,
+    };
+
     // Try to parse it with shell quoting. If we fail, make it one single big argument.
     if let Some(strings) = shlex::split(&extra_clang_args) {
         return strings;
@@ -296,7 +303,9 @@ impl Builder {
     /// Generate the Rust bindings using the options built up thus far.
     pub fn generate(mut self) -> Result<Bindings, BindgenError> {
         // Add any extra arguments from the environment to the clang command line.
-        self.options.clang_args.extend(get_extra_clang_args());
+        self.options
+            .clang_args
+            .extend(get_extra_clang_args(&self.options.parse_callbacks));
 
         // Transform input headers to arguments on the clang command line.
         self.options.clang_args.extend(
@@ -379,7 +388,7 @@ impl Builder {
             cmd.arg(a);
         }
 
-        for a in get_extra_clang_args() {
+        for a in get_extra_clang_args(&self.options.parse_callbacks) {
             cmd.arg(a);
         }
 
@@ -1152,22 +1161,38 @@ pub fn clang_version() -> ClangVersion {
     }
 }
 
+fn env_var<K: AsRef<str> + AsRef<OsStr>>(
+    parse_callbacks: &[Rc<dyn callbacks::ParseCallbacks>],
+    key: K,
+) -> Result<String, std::env::VarError> {
+    for callback in parse_callbacks {
+        callback.read_env_var(key.as_ref());
+    }
+    std::env::var(key)
+}
+
 /// Looks for the env var `var_${TARGET}`, and falls back to just `var` when it is not found.
-fn get_target_dependent_env_var(var: &str) -> Option<String> {
-    if let Ok(target) = env::var("TARGET") {
-        if let Ok(v) = env::var(format!("{}_{}", var, target)) {
+fn get_target_dependent_env_var(
+    parse_callbacks: &[Rc<dyn callbacks::ParseCallbacks>],
+    var: &str,
+) -> Option<String> {
+    if let Ok(target) = env_var(parse_callbacks, "TARGET") {
+        if let Ok(v) = env_var(parse_callbacks, format!("{}_{}", var, target)) {
             return Some(v);
         }
-        if let Ok(v) = env::var(format!("{}_{}", var, target.replace('-', "_")))
-        {
+        if let Ok(v) = env_var(
+            parse_callbacks,
+            format!("{}_{}", var, target.replace('-', "_")),
+        ) {
             return Some(v);
         }
     }
-    env::var(var).ok()
+
+    env_var(parse_callbacks, var).ok()
 }
 
 /// A ParseCallbacks implementation that will act on file includes by echoing a rerun-if-changed
-/// line
+/// line and on env variable usage by echoing a rerun-if-env-changed line
 ///
 /// When running inside a `build.rs` script, this can be used to make cargo invalidate the
 /// generated bindings whenever any of the files included from the header change:
@@ -1185,6 +1210,10 @@ impl callbacks::ParseCallbacks for CargoCallbacks {
     fn include_file(&self, filename: &str) {
         println!("cargo:rerun-if-changed={}", filename);
     }
+
+    fn read_env_var(&self, key: &str) {
+        println!("cargo:rerun-if-env-changed={}", key);
+    }
 }
 
 /// Test command_line_flag function.