diff --git a/compiler/rustc_target/src/spec/s390x_unknown_linux_gnu.rs b/compiler/rustc_target/src/spec/s390x_unknown_linux_gnu.rs
index cda88de0ea406..f2c722b9a89da 100644
--- a/compiler/rustc_target/src/spec/s390x_unknown_linux_gnu.rs
+++ b/compiler/rustc_target/src/spec/s390x_unknown_linux_gnu.rs
@@ -1,5 +1,5 @@
 use crate::abi::Endian;
-use crate::spec::{StackProbeType, Target};
+use crate::spec::{SanitizerSet, StackProbeType, Target};
 
 pub fn target() -> Target {
     let mut base = super::linux_gnu_base::opts();
@@ -13,6 +13,8 @@ pub fn target() -> Target {
     base.max_atomic_width = Some(64);
     base.min_global_align = Some(16);
     base.stack_probes = StackProbeType::Inline;
+    base.supported_sanitizers =
+        SanitizerSet::ADDRESS | SanitizerSet::LEAK | SanitizerSet::MEMORY | SanitizerSet::THREAD;
 
     Target {
         llvm_target: "s390x-unknown-linux-gnu".into(),
diff --git a/compiler/rustc_target/src/spec/s390x_unknown_linux_musl.rs b/compiler/rustc_target/src/spec/s390x_unknown_linux_musl.rs
index 91e63aee5e490..8fe9d023c527e 100644
--- a/compiler/rustc_target/src/spec/s390x_unknown_linux_musl.rs
+++ b/compiler/rustc_target/src/spec/s390x_unknown_linux_musl.rs
@@ -1,5 +1,5 @@
 use crate::abi::Endian;
-use crate::spec::{StackProbeType, Target};
+use crate::spec::{SanitizerSet, StackProbeType, Target};
 
 pub fn target() -> Target {
     let mut base = super::linux_musl_base::opts();
@@ -14,6 +14,8 @@ pub fn target() -> Target {
     base.min_global_align = Some(16);
     base.static_position_independent_executables = true;
     base.stack_probes = StackProbeType::Inline;
+    base.supported_sanitizers =
+        SanitizerSet::ADDRESS | SanitizerSet::LEAK | SanitizerSet::MEMORY | SanitizerSet::THREAD;
 
     Target {
         llvm_target: "s390x-unknown-linux-musl".into(),
diff --git a/src/bootstrap/native.rs b/src/bootstrap/native.rs
index e0d1504c9c780..cb5706ca0a651 100644
--- a/src/bootstrap/native.rs
+++ b/src/bootstrap/native.rs
@@ -1105,6 +1105,12 @@ fn supported_sanitizers(
         "x86_64-unknown-linux-musl" => {
             common_libs("linux", "x86_64", &["asan", "lsan", "msan", "tsan"])
         }
+        "s390x-unknown-linux-gnu" => {
+            common_libs("linux", "s390x", &["asan", "lsan", "msan", "tsan"])
+        }
+        "s390x-unknown-linux-musl" => {
+            common_libs("linux", "s390x", &["asan", "lsan", "msan", "tsan"])
+        }
         _ => Vec::new(),
     }
 }
diff --git a/src/ci/docker/host-x86_64/dist-s390x-linux/Dockerfile b/src/ci/docker/host-x86_64/dist-s390x-linux/Dockerfile
index 43a449b3a1926..adb98d7ebb545 100644
--- a/src/ci/docker/host-x86_64/dist-s390x-linux/Dockerfile
+++ b/src/ci/docker/host-x86_64/dist-s390x-linux/Dockerfile
@@ -28,5 +28,5 @@ ENV \
 
 ENV HOSTS=s390x-unknown-linux-gnu
 
-ENV RUST_CONFIGURE_ARGS --enable-extended --enable-lld --enable-profiler --disable-docs
+ENV RUST_CONFIGURE_ARGS --enable-extended --enable-lld --enable-sanitizers --enable-profiler --disable-docs
 ENV SCRIPT python3 ../x.py dist --host $HOSTS --target $HOSTS
diff --git a/src/tools/compiletest/src/util.rs b/src/tools/compiletest/src/util.rs
index 6c63b760ff6a9..ff7e8df987816 100644
--- a/src/tools/compiletest/src/util.rs
+++ b/src/tools/compiletest/src/util.rs
@@ -23,6 +23,7 @@ pub const ASAN_SUPPORTED_TARGETS: &[&str] = &[
     "x86_64-linux-android",
     "x86_64-unknown-freebsd",
     "x86_64-unknown-linux-gnu",
+    "s390x-unknown-linux-gnu",
 ];
 
 // FIXME(rcvalle): More targets are likely supported.
@@ -50,10 +51,15 @@ pub const LSAN_SUPPORTED_TARGETS: &[&str] = &[
     "aarch64-unknown-linux-gnu",
     "x86_64-apple-darwin",
     "x86_64-unknown-linux-gnu",
+    "s390x-unknown-linux-gnu",
 ];
 
-pub const MSAN_SUPPORTED_TARGETS: &[&str] =
-    &["aarch64-unknown-linux-gnu", "x86_64-unknown-freebsd", "x86_64-unknown-linux-gnu"];
+pub const MSAN_SUPPORTED_TARGETS: &[&str] = &[
+    "aarch64-unknown-linux-gnu",
+    "x86_64-unknown-freebsd",
+    "x86_64-unknown-linux-gnu",
+    "s390x-unknown-linux-gnu",
+];
 
 pub const TSAN_SUPPORTED_TARGETS: &[&str] = &[
     "aarch64-apple-darwin",
@@ -61,6 +67,7 @@ pub const TSAN_SUPPORTED_TARGETS: &[&str] = &[
     "x86_64-apple-darwin",
     "x86_64-unknown-freebsd",
     "x86_64-unknown-linux-gnu",
+    "s390x-unknown-linux-gnu",
 ];
 
 pub const HWASAN_SUPPORTED_TARGETS: &[&str] =