diff --git a/library/std/src/sys/fs/unix.rs b/library/std/src/sys/fs/unix.rs
index 914971934bfb0..d944bc9c9a2a0 100644
--- a/library/std/src/sys/fs/unix.rs
+++ b/library/std/src/sys/fs/unix.rs
@@ -1454,6 +1454,20 @@ impl File {
         Ok(())
     }
 
+    // FIXME(#115199): Rust currently omits weak function definitions
+    // and its metadata from LLVM IR.
+    #[cfg_attr(
+        any(
+            target_os = "android",
+            all(
+                target_os = "linux",
+                target_env = "gnu",
+                target_pointer_width = "32",
+                not(target_arch = "riscv32")
+            )
+        ),
+        no_sanitize(cfi)
+    )]
     pub fn set_times(&self, times: FileTimes) -> io::Result<()> {
         #[cfg(not(any(
             target_os = "redox",
diff --git a/library/std/src/sys/pal/unix/fd.rs b/library/std/src/sys/pal/unix/fd.rs
index 2fc33bdfefbf5..a08c7ccec2da3 100644
--- a/library/std/src/sys/pal/unix/fd.rs
+++ b/library/std/src/sys/pal/unix/fd.rs
@@ -251,6 +251,9 @@ impl FileDesc {
     }
 
     #[cfg(all(target_os = "android", target_pointer_width = "32"))]
+    // FIXME(#115199): Rust currently omits weak function definitions
+    // and its metadata from LLVM IR.
+    #[no_sanitize(cfi)]
     pub fn read_vectored_at(&self, bufs: &mut [IoSliceMut<'_>], offset: u64) -> io::Result<usize> {
         super::weak::weak!(fn preadv64(libc::c_int, *const libc::iovec, libc::c_int, off64_t) -> isize);
 
diff --git a/library/std/src/sys/pal/unix/process/process_unix.rs b/library/std/src/sys/pal/unix/process/process_unix.rs
index 25d9e9353320f..be9a7e919905f 100644
--- a/library/std/src/sys/pal/unix/process/process_unix.rs
+++ b/library/std/src/sys/pal/unix/process/process_unix.rs
@@ -434,6 +434,9 @@ impl Command {
         target_os = "nto",
         target_vendor = "apple",
     ))]
+    // FIXME(#115199): Rust currently omits weak function definitions
+    // and its metadata from LLVM IR.
+    #[cfg_attr(target_os = "linux", no_sanitize(cfi))]
     fn posix_spawn(
         &mut self,
         stdio: &ChildPipes,
diff --git a/library/std/src/sys/pal/unix/thread.rs b/library/std/src/sys/pal/unix/thread.rs
index 11f6998cac118..abe8d3fbf681e 100644
--- a/library/std/src/sys/pal/unix/thread.rs
+++ b/library/std/src/sys/pal/unix/thread.rs
@@ -188,6 +188,9 @@ impl Thread {
     }
 
     #[cfg(any(target_os = "solaris", target_os = "illumos", target_os = "nto"))]
+    // FIXME(#115199): Rust currently omits weak function definitions
+    // and its metadata from LLVM IR.
+    #[no_sanitize(cfi)]
     pub fn set_name(name: &CStr) {
         weak! {
             fn pthread_setname_np(
diff --git a/library/std/src/sys/pal/unix/time.rs b/library/std/src/sys/pal/unix/time.rs
index 0271626380c5f..c0a3044660b7e 100644
--- a/library/std/src/sys/pal/unix/time.rs
+++ b/library/std/src/sys/pal/unix/time.rs
@@ -96,6 +96,17 @@ impl Timespec {
         }
     }
 
+    // FIXME(#115199): Rust currently omits weak function definitions
+    // and its metadata from LLVM IR.
+    #[cfg_attr(
+        all(
+            target_os = "linux",
+            target_env = "gnu",
+            target_pointer_width = "32",
+            not(target_arch = "riscv32")
+        ),
+        no_sanitize(cfi)
+    )]
     pub fn now(clock: libc::clockid_t) -> Timespec {
         use crate::mem::MaybeUninit;
         use crate::sys::cvt;
diff --git a/library/std/src/sys/pal/unix/weak.rs b/library/std/src/sys/pal/unix/weak.rs
index 7ec4787f1eab7..ce3f66a83748b 100644
--- a/library/std/src/sys/pal/unix/weak.rs
+++ b/library/std/src/sys/pal/unix/weak.rs
@@ -144,6 +144,9 @@ unsafe fn fetch(name: &str) -> *mut libc::c_void {
 #[cfg(not(any(target_os = "linux", target_os = "android")))]
 pub(crate) macro syscall {
     (fn $name:ident($($arg_name:ident: $t:ty),*) -> $ret:ty) => (
+        // FIXME(#115199): Rust currently omits weak function definitions
+        // and its metadata from LLVM IR.
+        #[no_sanitize(cfi)]
         unsafe fn $name($($arg_name: $t),*) -> $ret {
             weak! { fn $name($($t),*) -> $ret }