diff --git a/compiler/rustc_trait_selection/src/error_reporting/traits/fulfillment_errors.rs b/compiler/rustc_trait_selection/src/error_reporting/traits/fulfillment_errors.rs
index 6872d038fb7f0..bccb04b4ff302 100644
--- a/compiler/rustc_trait_selection/src/error_reporting/traits/fulfillment_errors.rs
+++ b/compiler/rustc_trait_selection/src/error_reporting/traits/fulfillment_errors.rs
@@ -254,9 +254,16 @@ impl<'a, 'tcx> TypeErrCtxt<'a, 'tcx> {
                             LangItem::TransmuteTrait,
                         ) {
                             // Recompute the safe transmute reason and use that for the error reporting
+                            let (report_obligation, report_pred) =
+                                self.select_transmute_obligation_for_reporting(
+                                    &obligation,
+                                    main_trait_predicate,
+                                    root_obligation,
+                                );
+
                             match self.get_safe_transmute_error_and_reason(
-                                obligation.clone(),
-                                main_trait_predicate,
+                                report_obligation,
+                                report_pred,
                                 span,
                             ) {
                                 GetSafeTransmuteErrorAndReason::Silent => {
@@ -2793,6 +2800,51 @@ impl<'a, 'tcx> TypeErrCtxt<'a, 'tcx> {
             })
     }
 
+    fn select_transmute_obligation_for_reporting(
+        &self,
+        obligation: &PredicateObligation<'tcx>,
+        trait_predicate: ty::PolyTraitPredicate<'tcx>,
+        root_obligation: &PredicateObligation<'tcx>,
+    ) -> (PredicateObligation<'tcx>, ty::PolyTraitPredicate<'tcx>) {
+        let ocx = ObligationCtxt::new(self);
+        let normalized_predicate = self.tcx.erase_and_anonymize_regions(
+            self.tcx.instantiate_bound_regions_with_erased(trait_predicate),
+        );
+        let trait_ref = normalized_predicate.trait_ref;
+
+        let Ok(assume) = ocx.structurally_normalize_const(
+            &obligation.cause,
+            obligation.param_env,
+            trait_ref.args.const_at(2),
+        ) else {
+            return (obligation.clone(), trait_predicate);
+        };
+
+        let Some(assume) = rustc_transmute::Assume::from_const(self.tcx, assume) else {
+            return (obligation.clone(), trait_predicate);
+        };
+
+        let is_normalized_yes = matches!(
+            rustc_transmute::TransmuteTypeEnv::new(self.tcx).is_transmutable(
+                trait_ref.args.type_at(1),
+                trait_ref.args.type_at(0),
+                assume,
+            ),
+            rustc_transmute::Answer::Yes,
+        );
+
+        // If the normalized check unexpectedly passes, fall back to root obligation for reporting.
+        if is_normalized_yes
+            && let ty::PredicateKind::Clause(ty::ClauseKind::Trait(root_pred)) =
+                root_obligation.predicate.kind().skip_binder()
+            && root_pred.def_id() == trait_predicate.def_id()
+        {
+            return (root_obligation.clone(), root_obligation.predicate.kind().rebind(root_pred));
+        }
+
+        (obligation.clone(), trait_predicate)
+    }
+
     fn get_safe_transmute_error_and_reason(
         &self,
         obligation: PredicateObligation<'tcx>,
diff --git a/tests/ui/transmutability/type-alias-normalization.rs b/tests/ui/transmutability/type-alias-normalization.rs
new file mode 100644
index 0000000000000..8c8734c677e8d
--- /dev/null
+++ b/tests/ui/transmutability/type-alias-normalization.rs
@@ -0,0 +1,31 @@
+//! regression test for https://github.com/rust-lang/rust/issues/151462
+//@compile-flags: -Znext-solver=globally
+#![feature(lazy_type_alias, transmutability)]
+#![allow(incomplete_features)]
+mod assert {
+    use std::mem::{Assume, TransmuteFrom};
+
+    pub fn is_maybe_transmutable<Src, Dst>()
+    where
+        Src: TransmuteFrom<
+            Src,
+            {
+                Assume {
+                    alignment: true,
+                    lifetimes: true,
+                    safety: true,
+                    validity: true,
+                }
+            },
+        >,
+    {
+    }
+}
+
+fn test() {
+    type JustUnit = ();
+    assert::is_maybe_transmutable::<JustUnit, ()>();
+    //~^ ERROR `JustUnit` cannot be safely transmuted into `JustUnit`
+}
+
+fn main() {}
diff --git a/tests/ui/transmutability/type-alias-normalization.stderr b/tests/ui/transmutability/type-alias-normalization.stderr
new file mode 100644
index 0000000000000..d224f755c6119
--- /dev/null
+++ b/tests/ui/transmutability/type-alias-normalization.stderr
@@ -0,0 +1,29 @@
+error[E0277]: `JustUnit` cannot be safely transmuted into `JustUnit`
+  --> $DIR/type-alias-normalization.rs:27:37
+   |
+LL |     assert::is_maybe_transmutable::<JustUnit, ()>();
+   |                                     ^^^^^^^^ analyzing the transmutability of `JustUnit` is not yet supported
+   |
+note: required by a bound in `is_maybe_transmutable`
+  --> $DIR/type-alias-normalization.rs:10:14
+   |
+LL |       pub fn is_maybe_transmutable<Src, Dst>()
+   |              --------------------- required by a bound in this function
+LL |       where
+LL |           Src: TransmuteFrom<
+   |  ______________^
+LL | |             Src,
+LL | |             {
+LL | |                 Assume {
+...  |
+LL | |             },
+LL | |         >,
+   | |_________^ required by this bound in `is_maybe_transmutable`
+help: consider introducing a `where` clause, but there might be an alternative better way to express this requirement
+   |
+LL | fn test() where (): TransmuteFrom<(), Assume { alignment: true, lifetimes: true, safety: true, validity: true }> {
+   |           ++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
+
+error: aborting due to 1 previous error
+
+For more information about this error, try `rustc --explain E0277`.