diff --git a/graal-nodejs/doc/api/single-executable-applications.md b/graal-nodejs/doc/api/single-executable-applications.md
index 58454158816..147c927ee35 100644
--- a/graal-nodejs/doc/api/single-executable-applications.md
+++ b/graal-nodejs/doc/api/single-executable-applications.md
@@ -159,7 +159,8 @@ platforms:
 
 * Windows
 * macOS
-* Linux (AMD64 only)
+* Linux (all distributions [supported by Node.js][] except Alpine and all
+  architectures [supported by Node.js][] except s390x and ppc64)
 
 This is due to a lack of better tools to generate single-executables that can be
 used to test this feature on other platforms.
@@ -180,3 +181,4 @@ to help us document them.
 [postject]: https://github.com/nodejs/postject
 [signtool]: https://learn.microsoft.com/en-us/windows/win32/seccrypto/signtool
 [single executable applications]: https://github.com/nodejs/single-executable
+[supported by Node.js]: https://github.com/nodejs/node/blob/main/BUILDING.md#platform-list
diff --git a/graal-nodejs/doc/contributing/maintaining/maintaining-single-executable-application-support.md b/graal-nodejs/doc/contributing/maintaining/maintaining-single-executable-application-support.md
index e3957230f30..51cafb5ae6f 100644
--- a/graal-nodejs/doc/contributing/maintaining/maintaining-single-executable-application-support.md
+++ b/graal-nodejs/doc/contributing/maintaining/maintaining-single-executable-application-support.md
@@ -54,7 +54,9 @@ for the following features are in the list of work we'd like to get to:
 * Running an archive of multiple files.
 * Embedding [Node.js CLI options][] into the binary.
 * [XCOFF][] executable format.
-* Run tests on Linux architectures/distributions other than AMD64 Ubuntu.
+* Run tests on Alpine Linux.
+* Run tests on s390x Linux.
+* Run tests on ppc64 Linux.
 
 ## Disabling single executable application support
 
diff --git a/graal-nodejs/test/parallel/test-single-executable-application.js b/graal-nodejs/test/parallel/test-single-executable-application.js
index 01329ff2ae4..902093dc6e4 100644
--- a/graal-nodejs/test/parallel/test-single-executable-application.js
+++ b/graal-nodejs/test/parallel/test-single-executable-application.js
@@ -16,6 +16,11 @@ if (!process.config.variables.single_executable_application)
 if (!['darwin', 'win32', 'linux'].includes(process.platform))
   common.skip(`Unsupported platform ${process.platform}.`);
 
+if (process.platform === 'linux' && process.config.variables.asan) {
+  // Source of the memory leak - https://github.com/nodejs/node/blob/da0bc6db98cef98686122ea1e2cd2dbd2f52d123/src/node_sea.cc#L94.
+  common.skip('Running the resultant binary fails because of a memory leak ASAN error.');
+}
+
 if (process.platform === 'linux' && process.config.variables.is_debug === 1)
   common.skip('Running the resultant binary fails with `Couldn\'t read target executable"`.');
 
@@ -36,17 +41,16 @@ if (process.config.variables.want_separate_host_toolset !== 0)
   common.skip('Running the resultant binary fails with `Segmentation fault (core dumped)`.');
 
 if (process.platform === 'linux') {
-  try {
-    const osReleaseText = readFileSync('/etc/os-release', { encoding: 'utf-8' });
-    if (!/^NAME="Ubuntu"/m.test(osReleaseText)) {
-      throw new Error('Not Ubuntu.');
-    }
-  } catch {
-    common.skip('Only supported Linux distribution is Ubuntu.');
+  const osReleaseText = readFileSync('/etc/os-release', { encoding: 'utf-8' });
+  const isAlpine = /^NAME="Alpine Linux"/m.test(osReleaseText);
+  if (isAlpine) common.skip('Alpine Linux is not supported.');
+
+  if (process.arch === 's390x') {
+    common.skip('On s390x, postject fails with `memory access out of bounds`.');
   }
 
-  if (process.arch !== 'x64') {
-    common.skip(`Unsupported architecture for Linux - ${process.arch}.`);
+  if (process.arch === 'ppc64') {
+    common.skip('On ppc64, this test times out.');
   }
 }