diff --git a/source/core/index.ts b/source/core/index.ts
index b5b0525bf..81228384d 100644
--- a/source/core/index.ts
+++ b/source/core/index.ts
@@ -467,6 +467,12 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 			}
 
 			this._request.end((error?: Error | null) => {
+				// The request has been destroyed before `_final` finished.
+				// See https://github.com/nodejs/node/issues/39356
+				if ((this._request as any)._writableState?.errored) {
+					return;
+				}
+
 				if (!error) {
 					this._bodySize = this._uploadedSize;
 
diff --git a/test/stream.ts b/test/stream.ts
index 921eac50f..d20c8ce66 100644
--- a/test/stream.ts
+++ b/test/stream.ts
@@ -1,7 +1,7 @@
 import {promisify} from 'util';
 import fs from 'fs';
 import {Agent as HttpAgent} from 'http';
-import stream, {PassThrough as PassThroughStream, Readable as ReadableStream} from 'stream';
+import stream, {PassThrough as PassThroughStream, Readable as ReadableStream, Writable} from 'stream';
 import {Readable as Readable2} from 'readable-stream';
 import test from 'ava';
 import {Handler} from 'express';
@@ -497,6 +497,20 @@ test('accepts readable-stream as body', withServer, async (t, server, got) => {
 	t.is(response.body, 'ok');
 });
 
+test('prevents `Cannot call end` error', async t => {
+	const stream = got.stream('https://example.com', {
+		request: () => new Writable({
+			final() {}
+		}) as any,
+		timeout: {
+			request: 1
+		}
+	});
+
+	const error: RequestError = await pEvent(stream, 'error');
+	t.is(error.code, 'ETIMEDOUT');
+});
+
 if (Number.parseInt(process.versions.node.split('.')[0]!, 10) <= 12) {
 	test('does not emit end event on error', withServer, async (t, server, got) => {
 		server.get('/', infiniteHandler);