diff --git a/spyder_unittest/backend/runnerbase.py b/spyder_unittest/backend/runnerbase.py
index 13c815e5..d946e18a 100644
--- a/spyder_unittest/backend/runnerbase.py
+++ b/spyder_unittest/backend/runnerbase.py
@@ -10,14 +10,9 @@
 import tempfile
 
 # Third party imports
+from importlib.util import find_spec as find_spec_or_loader
 from qtpy.QtCore import (QObject, QProcess, QProcessEnvironment, QTextCodec,
                          Signal)
-from spyder.py3compat import to_text_string
-
-try:
-    from importlib.util import find_spec as find_spec_or_loader
-except ImportError:  # Python 2
-    from pkgutil import find_loader as find_spec_or_loader
 
 
 # if generating coverage report, use this name for the TestResult
@@ -244,7 +239,7 @@ def read_all_process_output(self):
         """Read and return all output from `self.process` as unicode."""
         qbytearray = self.process.readAllStandardOutput()
         locale_codec = QTextCodec.codecForLocale()
-        return to_text_string(locale_codec.toUnicode(qbytearray.data()))
+        return locale_codec.toUnicode(qbytearray.data())
 
     def stop_if_running(self):
         """Stop testing process if it is running."""
diff --git a/spyder_unittest/backend/tests/test_pytestrunner.py b/spyder_unittest/backend/tests/test_pytestrunner.py
index c5d9aad5..19804ff4 100644
--- a/spyder_unittest/backend/tests/test_pytestrunner.py
+++ b/spyder_unittest/backend/tests/test_pytestrunner.py
@@ -9,6 +9,7 @@
 import os
 import os.path as osp
 import sys
+from unittest.mock import Mock
 
 # Third party imports
 import pytest
@@ -20,11 +21,6 @@
                                                 COV_TEST_NAME)
 from spyder_unittest.widgets.configdialog import Config
 
-try:
-    from unittest.mock import Mock
-except ImportError:
-    from mock import Mock  # Python 2
-
 
 def test_pytestrunner_is_installed():
     assert PyTestRunner(None).is_installed()
diff --git a/spyder_unittest/backend/tests/test_pytestworker.py b/spyder_unittest/backend/tests/test_pytestworker.py
index 0446db0e..978e1401 100644
--- a/spyder_unittest/backend/tests/test_pytestworker.py
+++ b/spyder_unittest/backend/tests/test_pytestworker.py
@@ -7,6 +7,7 @@
 
 # Standard library imports
 import os
+from unittest.mock import call, create_autospec, MagicMock, Mock
 
 # Third party imports
 import pytest
@@ -15,11 +16,6 @@
 from spyder_unittest.backend.pytestworker import SpyderPlugin, main
 from spyder_unittest.backend.zmqstream import ZmqStreamWriter
 
-try:
-    from unittest.mock import call, create_autospec, MagicMock, Mock
-except ImportError:
-    from mock import call, create_autospec, MagicMock, Mock  # Python 2
-
 
 class EmptyClass:
     pass
diff --git a/spyder_unittest/backend/tests/test_runnerbase.py b/spyder_unittest/backend/tests/test_runnerbase.py
index 4443f794..3e121691 100644
--- a/spyder_unittest/backend/tests/test_runnerbase.py
+++ b/spyder_unittest/backend/tests/test_runnerbase.py
@@ -7,6 +7,7 @@
 
 # Standard library imports
 import os
+from unittest.mock import Mock
 
 # Third party imports
 import pytest
@@ -15,11 +16,6 @@
 from spyder_unittest.backend.runnerbase import RunnerBase
 from spyder_unittest.widgets.configdialog import Config
 
-try:
-    from unittest.mock import Mock
-except ImportError:
-    from mock import Mock  # Python 2
-
 
 def test_runnerbase_with_nonexisting_module():
     class FooRunner(RunnerBase):
diff --git a/spyder_unittest/backend/zmqstream.py b/spyder_unittest/backend/zmqstream.py
index a764440f..d394476e 100644
--- a/spyder_unittest/backend/zmqstream.py
+++ b/spyder_unittest/backend/zmqstream.py
@@ -11,8 +11,6 @@
 process can then use the stream to send its result to the reader.
 """
 
-from __future__ import print_function
-
 # Standard library imports
 import sys
 
@@ -68,7 +66,7 @@ class ZmqStreamReader(QObject):
 
     def __init__(self):
         """Constructor; also constructs ZMQ stream."""
-        super(QObject, self).__init__()
+        super().__init__()
         self.context = zmq.Context()
         self.socket = self.context.socket(zmq.PAIR)
         self.port = self.socket.bind_to_random_port('tcp://*')
diff --git a/spyder_unittest/tests/test_unittestplugin.py b/spyder_unittest/tests/test_unittestplugin.py
index 9201bd36..b73e369c 100644
--- a/spyder_unittest/tests/test_unittestplugin.py
+++ b/spyder_unittest/tests/test_unittestplugin.py
@@ -8,16 +8,12 @@
 # Third party imports
 import pytest
 from spyder.plugins.projects.api import EmptyProject
+from unittest.mock import MagicMock
 
 # Local imports
 from spyder_unittest.unittestplugin import UnitTestPlugin
 from spyder_unittest.widgets.configdialog import Config
 
-try:
-    from unittest.mock import MagicMock
-except ImportError:
-    from mock import MagicMock  # Python 2
-
 
 class PluginForTesting(UnitTestPlugin):
     CONF_FILE = False
diff --git a/spyder_unittest/unittestplugin.py b/spyder_unittest/unittestplugin.py
index de6389b6..43a72969 100644
--- a/spyder_unittest/unittestplugin.py
+++ b/spyder_unittest/unittestplugin.py
@@ -6,6 +6,7 @@
 """Unit testing Plugin."""
 
 # Standard library imports
+from os import getcwd
 import os.path as osp
 
 # Third party imports
@@ -14,7 +15,6 @@
 from spyder.config.base import get_translation
 from spyder.config.gui import is_dark_interface
 from spyder.plugins.mainmenu.api import ApplicationMenus
-from spyder.py3compat import PY2, getcwd
 
 # Local imports
 from spyder_unittest.widgets.configdialog import Config
@@ -98,30 +98,6 @@ def on_initialize(self):
             register_shortcut=True)
         #  TODO: shortcut="Shift+Alt+F11"
 
-    # --- Optional SpyderDockablePlugin methods -------------------------------
-
-    @staticmethod
-    def check_compatibility():
-        """
-        Check compatibility of the plugin.
-
-        This checks that the plugin is not run under Python 2.
-
-        Returns
-        -------
-        (bool, str)
-            The first value tells Spyder if the plugin has passed the
-            compatibility test defined in this method. The second value
-            is a message that must explain users why the plugin was
-            found to be incompatible (e.g. 'This plugin does not work
-            with PyQt4'). It will be shown at startup in a QMessageBox.
-        """
-        if PY2:
-            msg = _('The unittest plugin does not work with Python 2.')
-            return (False, msg)
-        else:
-            return (True, '')
-
     # ----- Set up interactions with other plugins ----------------------------
 
     @on_plugin_available(plugin=Plugins.Editor)
diff --git a/spyder_unittest/widgets/configdialog.py b/spyder_unittest/widgets/configdialog.py
index 8b0575c7..7c40be5d 100644
--- a/spyder_unittest/widgets/configdialog.py
+++ b/spyder_unittest/widgets/configdialog.py
@@ -11,6 +11,8 @@
 
 # Standard library imports
 from collections import namedtuple
+from os import getcwd
+from pkgutil import find_loader as find_spec_or_loader
 import os.path as osp
 
 # Third party imports
@@ -20,13 +22,8 @@
                             QHBoxLayout, QLabel, QLineEdit, QPushButton,
                             QVBoxLayout, QCheckBox)
 from spyder.config.base import get_translation
-from spyder.py3compat import getcwd, to_text_string
 from spyder.utils import icon_manager as ima
 
-try:
-    from importlib.util import find_spec as find_spec_or_loader
-except ImportError:  # Python 2
-    from pkgutil import find_loader as find_spec_or_loader
 
 try:
     _ = get_translation('spyder_unittest')
@@ -62,7 +59,7 @@ def __init__(self, frameworks, config, parent=None):
             Initial configuration
         parent : QWidget
         """
-        super(ConfigDialog, self).__init__(parent)
+        super().__init__(parent)
         self.setWindowTitle(_('Configure tests'))
         layout = QVBoxLayout(self)
 
@@ -145,7 +142,7 @@ def framework_changed(self, index):
 
     def select_directory(self):
         """Display dialog for user to select working directory."""
-        basedir = to_text_string(self.wdir_lineedit.text())
+        basedir = self.wdir_lineedit.text()
         if not osp.isdir(basedir):
             basedir = getcwd()
         title = _("Select directory")
diff --git a/spyder_unittest/widgets/tests/test_datatree.py b/spyder_unittest/widgets/tests/test_datatree.py
index a080788c..fc42f470 100644
--- a/spyder_unittest/widgets/tests/test_datatree.py
+++ b/spyder_unittest/widgets/tests/test_datatree.py
@@ -8,6 +8,7 @@
 # Third party imports
 from qtpy.QtCore import QModelIndex, QPoint, Qt
 from qtpy.QtGui import QContextMenuEvent
+from unittest.mock import Mock
 import pytest
 
 # Local imports
@@ -15,11 +16,6 @@
 from spyder_unittest.widgets.datatree import (COLORS, COLORS_DARK,
                                               TestDataModel, TestDataView)
 
-try:
-    from unittest.mock import Mock
-except ImportError:
-    from mock import Mock  # Python 2
-
 
 @pytest.fixture
 def view_and_model(qtbot):
diff --git a/spyder_unittest/widgets/tests/test_unittestgui.py b/spyder_unittest/widgets/tests/test_unittestgui.py
index 78ec7c5a..57d38dbf 100644
--- a/spyder_unittest/widgets/tests/test_unittestgui.py
+++ b/spyder_unittest/widgets/tests/test_unittestgui.py
@@ -8,6 +8,7 @@
 # Standard library imports
 import os
 import sys
+from unittest.mock import Mock
 
 # Third party imports
 from qtpy.QtCore import Qt, QProcess
@@ -19,11 +20,6 @@
 from spyder_unittest.widgets.configdialog import Config
 from spyder_unittest.widgets.unittestgui import UnitTestWidget
 
-try:
-    from unittest.mock import Mock
-except ImportError:
-    from mock import Mock  # Python 2
-
 
 @pytest.fixture
 def widget(qtbot):
diff --git a/spyder_unittest/widgets/unittestgui.py b/spyder_unittest/widgets/unittestgui.py
index fceea8b9..f5155f6b 100644
--- a/spyder_unittest/widgets/unittestgui.py
+++ b/spyder_unittest/widgets/unittestgui.py
@@ -5,8 +5,6 @@
 # (see LICENSE.txt for details)
 """Unit Testing widget."""
 
-from __future__ import with_statement
-
 # Standard library imports
 import copy
 import os.path as osp
@@ -19,22 +17,16 @@
 from spyder.config.base import get_conf_path, get_translation
 from spyder.utils import icon_manager as ima
 from spyder.plugins.variableexplorer.widgets.texteditor import TextEditor
-from spyder.py3compat import PY3
 
 # Local imports
 from spyder_unittest.backend.frameworkregistry import FrameworkRegistry
 from spyder_unittest.backend.noserunner import NoseRunner
+from spyder_unittest.backend.pytestrunner import PyTestRunner
 from spyder_unittest.backend.runnerbase import Category, TestResult
 from spyder_unittest.backend.unittestrunner import UnittestRunner
 from spyder_unittest.widgets.configdialog import Config, ask_for_config
 from spyder_unittest.widgets.datatree import TestDataModel, TestDataView
 
-# This import uses Python 3 syntax, so importing it under Python 2 throws
-# a SyntaxError which means that the plugin's check_compatibility method
-# will never run.
-if PY3:
-    from spyder_unittest.backend.pytestrunner import PyTestRunner
-
 # This is needed for testing this module as a stand alone script
 try:
     _ = get_translation('spyder_unittest')
@@ -42,11 +34,8 @@
     import gettext
     _ = gettext.gettext
 
-# Supported testing framework
-if PY3:
-    FRAMEWORKS = {NoseRunner, PyTestRunner, UnittestRunner}
-else:
-    FRAMEWORKS = {NoseRunner, UnittestRunner}
+# Supported testing frameworks
+FRAMEWORKS = {NoseRunner, PyTestRunner, UnittestRunner}
 
 
 class UnitTestWidgetActions: