diff --git a/src/Sqids/SqidsEncoder.cs b/src/Sqids/SqidsEncoder.cs
index 10ed482..28b4899 100644
--- a/src/Sqids/SqidsEncoder.cs
+++ b/src/Sqids/SqidsEncoder.cs
@@ -110,8 +110,14 @@ public SqidsEncoder(SqidsOptions options)
 			StringComparer.OrdinalIgnoreCase // NOTE: Effectively removes items that differ only in casing — leaves one version of each word casing-wise which will then be compared against the generated IDs case-insensitively
 		);
 		options.BlockList.RemoveWhere(w =>
-			w.Length < 3 || // NOTE: Removes words that are less than 3 characters long
-			w.Any(c => !options.Alphabet.Contains(c)) // NOTE: Removes words that contain characters not found in the alphabet
+			// NOTE: Removes words that are less than 3 characters long
+			w.Length < 3 ||
+			// NOTE: Removes words that contain characters not found in the alphabet
+#if NETSTANDARD2_0
+			w.Any(c => options.Alphabet.IndexOf(c.ToString(), StringComparison.OrdinalIgnoreCase) == -1) // NOTE: A `string.Contains` overload with `StringComparison` didn't exist prior to .NET Standard 2.1, so we have to resort to `IndexOf` — see https://stackoverflow.com/a/52791476
+#else
+			w.Any(c => !options.Alphabet.Contains(c, StringComparison.OrdinalIgnoreCase))
+#endif
 		);
 		_blockList = options.BlockList.ToArray(); // NOTE: Arrays are faster to iterate than HashSets, so we construct an array here.
 
diff --git a/test/Sqids.Tests/BlockListTests.cs b/test/Sqids.Tests/BlockListTests.cs
index 1f95335..080b1dc 100644
--- a/test/Sqids.Tests/BlockListTests.cs
+++ b/test/Sqids.Tests/BlockListTests.cs
@@ -122,4 +122,24 @@ public void EncodeAndDecode_WithShortCustomBlockList_RoundTripsSuccessfully()
 
 		sqids.Decode(sqids.Encode(1000)).ShouldBeEquivalentTo(new[] { 1000 });
 	}
+
+	[Test]
+	public void EncodeAndDecode_WithLowerCaseBlockListAndUpperCaseAlphabet_IgnoresCasing()
+	{
+#if NET7_0_OR_GREATER
+		var sqids = new SqidsEncoder<int>(new()
+#else
+		var sqids = new SqidsEncoder(new()
+#endif
+		{
+			Alphabet = "ABCDEFGHIJKLMNOPQRSTUVWXYZ",
+			BlockList = new()
+			{
+				"sqnmpn", // NOTE: The uppercase version of this is the default encoding of [1,2,3]
+			},
+		});
+
+		sqids.Encode(1, 2, 3).ShouldBe("ULPBZGBM"); // NOTE: Without the blocklist, would've been "SQNMPN".
+		sqids.Decode("ULPBZGBM").ShouldBeEquivalentTo(new[] { 1, 2, 3 });
+	}
 }