diff --git a/instrumentation/runtime-telemetry/runtime-telemetry-java8/javaagent/src/main/java/io/opentelemetry/instrumentation/javaagent/runtimemetrics/java8/JarAnalyzer.java b/instrumentation/runtime-telemetry/runtime-telemetry-java8/javaagent/src/main/java/io/opentelemetry/instrumentation/javaagent/runtimemetrics/java8/JarAnalyzer.java
index ad3f2ea8cda0..9f48d5610f9e 100644
--- a/instrumentation/runtime-telemetry/runtime-telemetry-java8/javaagent/src/main/java/io/opentelemetry/instrumentation/javaagent/runtimemetrics/java8/JarAnalyzer.java
+++ b/instrumentation/runtime-telemetry/runtime-telemetry-java8/javaagent/src/main/java/io/opentelemetry/instrumentation/javaagent/runtimemetrics/java8/JarAnalyzer.java
@@ -18,6 +18,7 @@
 import io.opentelemetry.instrumentation.runtimemetrics.java8.internal.JmxRuntimeMetricsUtil;
 import io.opentelemetry.sdk.common.Clock;
 import io.opentelemetry.sdk.internal.DaemonThreadFactory;
+import java.io.File;
 import java.io.IOException;
 import java.lang.instrument.ClassFileTransformer;
 import java.net.URI;
@@ -131,6 +132,22 @@ private void handle(ProtectionDomain protectionDomain) {
       return;
     }
 
+    // Payara 5 and 6 have url with file protocol that fail on openStream with
+    // java.io.IOException: no entry name specified
+    //   at
+    // java.base/sun.net.www.protocol.jar.JarURLConnection.getInputStream(JarURLConnection.java:160)
+    // To avoid this here we recreate the URL when it points to a file.
+    if ("file".equals(archiveUrl.getProtocol())) {
+      try {
+        File archiveFile = new File(archiveUrl.toURI().getSchemeSpecificPart());
+        if (archiveFile.exists() && archiveFile.isFile()) {
+          archiveUrl = archiveFile.toURI().toURL();
+        }
+      } catch (Exception e) {
+        logger.log(Level.WARNING, "Unable to normalize location URL: " + archiveUrl, e);
+      }
+    }
+
     // Only code locations with .jar and .war extension should make it here
     toProcess.add(archiveUrl);
   }