diff --git a/test/AutoDiff/validation-test/differentiable_protocol_requirements.swift b/test/AutoDiff/validation-test/differentiable_protocol_requirements.swift
index bff9fabe78503..1810750ea4e69 100644
--- a/test/AutoDiff/validation-test/differentiable_protocol_requirements.swift
+++ b/test/AutoDiff/validation-test/differentiable_protocol_requirements.swift
@@ -1,6 +1,12 @@
 // RUN: %target-run-simple-swift
 // REQUIRES: executable_test
 
+// Disabled due to test failure with `-O`: SR-13250.
+// SR-13250 is tracking the fix for compiling this test with optimizations.
+// XFAIL: swift_test_mode_optimize
+// XFAIL: swift_test_mode_optimize_size
+// XFAIL: swift_test_mode_optimize_unchecked
+
 import StdlibUnittest
 import DifferentiationUnittest