diff --git a/CHANGELOG.md b/CHANGELOG.md
index 31c8de14d10a..9eee072c1ddd 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -20,6 +20,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Fixed
 
 - Ensure classes containing `--` are extracted correctly ([#16972](https://github.com/tailwindlabs/tailwindcss/pull/16972))
+- Ensure classes containing numbers followed by dash or underscore are extracted correctly ([#16980](https://github.com/tailwindlabs/tailwindcss/pull/16980))
 
 ## [4.0.10] - 2025-03-05
 
diff --git a/crates/oxide/src/extractor/mod.rs b/crates/oxide/src/extractor/mod.rs
index 0a5b972dcb08..ba89bbf9063d 100644
--- a/crates/oxide/src/extractor/mod.rs
+++ b/crates/oxide/src/extractor/mod.rs
@@ -833,6 +833,15 @@ mod tests {
         );
     }
 
+    // https://github.com/tailwindlabs/tailwindcss/issues/16978
+    #[test]
+    fn test_classes_containing_number_followed_by_dash_or_underscore() {
+        assert_extract_sorted_candidates(
+            r#"<div class="text-Title1_Strong"></div>"#,
+            vec!["text-Title1_Strong"],
+        );
+    }
+
     #[test]
     fn test_extract_css_variables() {
         for (input, expected) in [
diff --git a/crates/oxide/src/extractor/named_utility_machine.rs b/crates/oxide/src/extractor/named_utility_machine.rs
index a7fab0407a64..3483abe29c1e 100644
--- a/crates/oxide/src/extractor/named_utility_machine.rs
+++ b/crates/oxide/src/extractor/named_utility_machine.rs
@@ -243,7 +243,8 @@ impl Machine for NamedUtilityMachine {
                         }
 
                         // A number must be preceded by a `-`, `.` or another alphanumeric
-                        // character, and can be followed by a `.` or an alphanumeric character.
+                        // character, and can be followed by a `.` or an alphanumeric character or
+                        // dash or underscore.
                         //
                         // E.g.: `text-2xs`
                         //            ^^
@@ -272,6 +273,8 @@ impl Machine for NamedUtilityMachine {
                                     | Class::AlphaLower
                                     | Class::AlphaUpper
                                     | Class::Percent
+                                    | Class::Underscore
+                                    | Class::Dash
                             ) {
                                 return self.done(self.start_pos, cursor);
                             }
@@ -395,6 +398,9 @@ mod tests {
             // With numbers
             ("px-5", vec!["px-5"]),
             ("px-2.5", vec!["px-2.5"]),
+            // With number followed by dash or underscore
+            ("text-title1-strong", vec!["text-title1-strong"]),
+            ("text-title1_strong", vec!["text-title1_strong"]),
             // With trailing % sign
             ("from-15%", vec!["from-15%"]),
             // Arbitrary value with bracket notation