diff --git a/CHANGELOG.md b/CHANGELOG.md
index 45f2264e8324..9f7d9be27aa5 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -17,6 +17,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Handle `@variant` inside `@custom-variant` ([#18885](https://github.com/tailwindlabs/tailwindcss/pull/18885))
 - Merge suggestions when using `@utility` ([#18900](https://github.com/tailwindlabs/tailwindcss/pull/18900))
 - Ensure that file system watchers created when using the CLI are always cleaned up ([#18905](https://github.com/tailwindlabs/tailwindcss/pull/18905))
+- Do not generate `grid-column` utilities when configuring `grid-column-start` or `grid-column-end` ([#18907](https://github.com/tailwindlabs/tailwindcss/pull/18907))
+- Do not generate `grid-row` utilities when configuring `grid-row-start` or `grid-row-end` ([#18907](https://github.com/tailwindlabs/tailwindcss/pull/18907))
 
 ## [4.1.13] - 2025-09-03
 
diff --git a/packages/tailwindcss/src/theme.ts b/packages/tailwindcss/src/theme.ts
index dc9c750a12f8..073fb242f1e0 100644
--- a/packages/tailwindcss/src/theme.ts
+++ b/packages/tailwindcss/src/theme.ts
@@ -28,6 +28,8 @@ const ignoredThemeKeyMap = new Map([
       '--text-underline-offset',
     ],
   ],
+  ['--grid-column', ['--grid-column-start', '--grid-column-end']],
+  ['--grid-row', ['--grid-row-start', '--grid-row-end']],
 ])
 
 function isIgnoredThemeKey(themeKey: ThemeKey, namespace: ThemeKey) {
diff --git a/packages/tailwindcss/src/utilities.test.ts b/packages/tailwindcss/src/utilities.test.ts
index 32a01fda86eb..5a1fe7596014 100644
--- a/packages/tailwindcss/src/utilities.test.ts
+++ b/packages/tailwindcss/src/utilities.test.ts
@@ -1180,9 +1180,28 @@ test('col', async () => {
 
 test('col-start', async () => {
   expect(
-    await run(['col-start-auto', 'col-start-4', 'col-start-99', 'col-start-[123]', '-col-start-4']),
+    await compileCss(
+      css`
+        @theme {
+          --grid-column-start-custom: 1 column-start;
+        }
+        @tailwind utilities;
+      `,
+      [
+        'col-start-auto',
+        'col-start-4',
+        'col-start-99',
+        'col-start-[123]',
+        '-col-start-4',
+        'col-start-custom',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
-    ".-col-start-4 {
+    ":root, :host {
+      --grid-column-start-custom: 1 column-start;
+    }
+
+    .-col-start-4 {
       grid-column-start: calc(4 * -1);
     }
 
@@ -1200,6 +1219,10 @@ test('col-start', async () => {
 
     .col-start-auto {
       grid-column-start: auto;
+    }
+
+    .col-start-custom {
+      grid-column-start: var(--grid-column-start-custom);
     }"
   `)
   expect(
@@ -1217,28 +1240,45 @@ test('col-start', async () => {
 })
 
 test('col-end', async () => {
-  expect(await run(['col-end-auto', 'col-end-4', 'col-end-99', 'col-end-[123]', '-col-end-4']))
-    .toMatchInlineSnapshot(`
-      ".-col-end-4 {
-        grid-column-end: calc(4 * -1);
-      }
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --grid-column-end-custom: 1 column-end;
+        }
+        @tailwind utilities;
+      `,
+      ['col-end-auto', 'col-end-4', 'col-end-99', 'col-end-[123]', '-col-end-4', 'col-end-custom'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root, :host {
+      --grid-column-end-custom: 1 column-end;
+    }
 
-      .col-end-4 {
-        grid-column-end: 4;
-      }
+    .-col-end-4 {
+      grid-column-end: calc(4 * -1);
+    }
 
-      .col-end-99 {
-        grid-column-end: 99;
-      }
+    .col-end-4 {
+      grid-column-end: 4;
+    }
 
-      .col-end-\\[123\\] {
-        grid-column-end: 123;
-      }
+    .col-end-99 {
+      grid-column-end: 99;
+    }
 
-      .col-end-auto {
-        grid-column-end: auto;
-      }"
-    `)
+    .col-end-\\[123\\] {
+      grid-column-end: 123;
+    }
+
+    .col-end-auto {
+      grid-column-end: auto;
+    }
+
+    .col-end-custom {
+      grid-column-end: var(--grid-column-end-custom);
+    }"
+  `)
   expect(
     await run([
       'col-end',
@@ -1317,9 +1357,28 @@ test('row', async () => {
 
 test('row-start', async () => {
   expect(
-    await run(['row-start-auto', 'row-start-4', 'row-start-99', 'row-start-[123]', '-row-start-4']),
+    await compileCss(
+      css`
+        @theme {
+          --grid-row-start-custom: 1 row-start;
+        }
+        @tailwind utilities;
+      `,
+      [
+        'row-start-auto',
+        'row-start-4',
+        'row-start-99',
+        'row-start-[123]',
+        '-row-start-4',
+        'row-start-custom',
+      ],
+    ),
   ).toMatchInlineSnapshot(`
-    ".-row-start-4 {
+    ":root, :host {
+      --grid-row-start-custom: 1 row-start;
+    }
+
+    .-row-start-4 {
       grid-row-start: calc(4 * -1);
     }
 
@@ -1337,6 +1396,10 @@ test('row-start', async () => {
 
     .row-start-auto {
       grid-row-start: auto;
+    }
+
+    .row-start-custom {
+      grid-row-start: var(--grid-row-start-custom);
     }"
   `)
   expect(
@@ -1354,28 +1417,45 @@ test('row-start', async () => {
 })
 
 test('row-end', async () => {
-  expect(await run(['row-end-auto', 'row-end-4', 'row-end-99', 'row-end-[123]', '-row-end-4']))
-    .toMatchInlineSnapshot(`
-      ".-row-end-4 {
-        grid-row-end: calc(4 * -1);
-      }
+  expect(
+    await compileCss(
+      css`
+        @theme {
+          --grid-row-end-custom: 1 row-end;
+        }
+        @tailwind utilities;
+      `,
+      ['row-end-auto', 'row-end-4', 'row-end-99', 'row-end-[123]', '-row-end-4', 'row-end-custom'],
+    ),
+  ).toMatchInlineSnapshot(`
+    ":root, :host {
+      --grid-row-end-custom: 1 row-end;
+    }
 
-      .row-end-4 {
-        grid-row-end: 4;
-      }
+    .-row-end-4 {
+      grid-row-end: calc(4 * -1);
+    }
 
-      .row-end-99 {
-        grid-row-end: 99;
-      }
+    .row-end-4 {
+      grid-row-end: 4;
+    }
 
-      .row-end-\\[123\\] {
-        grid-row-end: 123;
-      }
+    .row-end-99 {
+      grid-row-end: 99;
+    }
 
-      .row-end-auto {
-        grid-row-end: auto;
-      }"
-    `)
+    .row-end-\\[123\\] {
+      grid-row-end: 123;
+    }
+
+    .row-end-auto {
+      grid-row-end: auto;
+    }
+
+    .row-end-custom {
+      grid-row-end: var(--grid-row-end-custom);
+    }"
+  `)
   expect(
     await run([
       'row-end',