diff --git a/pyproject.toml b/pyproject.toml
index 0e78d4e..ef1dced 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -6,7 +6,7 @@ authors = [
     { name = "zietzm", email = "michael.zietz@gmail.com" }
 ]
 dependencies = [
-    "fastapi>=0.111.0",
+    "fastapi[standard]>=0.111.0",
     "boto3>=1.34.145",
     "botocore>=1.34.145",
     "pydantic>=2.8.2",
@@ -50,3 +50,10 @@ packages = ["src/webgwas_backend"]
 
 [tool.ruff.lint.pydocstyle]
 convention = "google"
+
+[tool.uv]
+dev-dependencies = [
+    "pytest>=8.3.2",
+    "ruff>=0.6.2",
+    "httpx>=0.27.2",
+]
diff --git a/requirements-dev.lock b/requirements-dev.lock
index fc01265..b77aab7 100644
--- a/requirements-dev.lock
+++ b/requirements-dev.lock
@@ -53,6 +53,8 @@ idna==3.7
     # via anyio
     # via email-validator
     # via httpx
+igwas @ git+https://github.com/tatonetti-lab/indirect-gwas@e0546ff0fe39624cfab9bd02cec80dcdd14e5af7
+    # via webgwas
 iniconfig==2.0.0
     # via pytest
 jinja2==3.1.4
@@ -60,21 +62,27 @@ jinja2==3.1.4
 jmespath==1.0.1
     # via boto3
     # via botocore
+joblib==1.4.2
+    # via scikit-learn
 markdown-it-py==3.0.0
     # via rich
 markupsafe==2.1.5
     # via jinja2
 mdurl==0.1.2
     # via markdown-it-py
-numpy==2.0.1
+numpy==2.1.0
+    # via igwas
     # via pandas
     # via pyarrow
+    # via scikit-learn
+    # via scipy
     # via webgwas
 orjson==3.10.6
     # via fastapi
 packaging==24.1
     # via pytest
 pandas==2.2.2
+    # via igwas
     # via webgwas
     # via webgwas-backend
 pluggy==1.5.0
@@ -114,6 +122,10 @@ rich==13.7.1
 ruff==0.6.2
 s3transfer==0.10.2
     # via boto3
+scikit-learn==1.5.1
+    # via webgwas-backend
+scipy==1.14.1
+    # via scikit-learn
 shellingham==1.5.4
     # via typer
 six==1.16.0
@@ -127,6 +139,8 @@ sqlmodel==0.0.21
     # via webgwas-backend
 starlette==0.37.2
     # via fastapi
+threadpoolctl==3.5.0
+    # via scikit-learn
 typer==0.12.3
     # via fastapi-cli
     # via webgwas-backend
@@ -148,9 +162,10 @@ uvloop==0.19.0
     # via uvicorn
 watchfiles==0.22.0
     # via uvicorn
-webgwas @ git+https://github.com/zietzm/webgwas.git@bb627b570e507222accd2fdf08a896565835db0d
+webgwas @ git+https://github.com/zietzm/webgwas.git@fa93c0bbb02ab92c03af5975bbb36770f7c70445
     # via webgwas-backend
 websockets==12.0
     # via uvicorn
 zstandard==0.23.0
+    # via igwas
     # via webgwas-backend
diff --git a/requirements.lock b/requirements.lock
index 9488afe..910e08c 100644
--- a/requirements.lock
+++ b/requirements.lock
@@ -53,24 +53,32 @@ idna==3.7
     # via anyio
     # via email-validator
     # via httpx
+igwas @ git+https://github.com/tatonetti-lab/indirect-gwas@e0546ff0fe39624cfab9bd02cec80dcdd14e5af7
+    # via webgwas
 jinja2==3.1.4
     # via fastapi
 jmespath==1.0.1
     # via boto3
     # via botocore
+joblib==1.4.2
+    # via scikit-learn
 markdown-it-py==3.0.0
     # via rich
 markupsafe==2.1.5
     # via jinja2
 mdurl==0.1.2
     # via markdown-it-py
-numpy==2.0.1
+numpy==2.1.0
+    # via igwas
     # via pandas
     # via pyarrow
+    # via scikit-learn
+    # via scipy
     # via webgwas
 orjson==3.10.6
     # via fastapi
 pandas==2.2.2
+    # via igwas
     # via webgwas
     # via webgwas-backend
 polars==1.3.0
@@ -106,6 +114,10 @@ rich==13.7.1
     # via webgwas-backend
 s3transfer==0.10.2
     # via boto3
+scikit-learn==1.5.1
+    # via webgwas-backend
+scipy==1.14.1
+    # via scikit-learn
 shellingham==1.5.4
     # via typer
 six==1.16.0
@@ -119,6 +131,8 @@ sqlmodel==0.0.21
     # via webgwas-backend
 starlette==0.37.2
     # via fastapi
+threadpoolctl==3.5.0
+    # via scikit-learn
 typer==0.12.3
     # via fastapi-cli
     # via webgwas-backend
@@ -140,9 +154,10 @@ uvloop==0.19.0
     # via uvicorn
 watchfiles==0.22.0
     # via uvicorn
-webgwas @ git+https://github.com/zietzm/webgwas.git@bb627b570e507222accd2fdf08a896565835db0d
+webgwas @ git+https://github.com/zietzm/webgwas.git@fa93c0bbb02ab92c03af5975bbb36770f7c70445
     # via webgwas-backend
 websockets==12.0
     # via uvicorn
 zstandard==0.23.0
+    # via igwas
     # via webgwas-backend
diff --git a/src/webgwas_backend/main.py b/src/webgwas_backend/main.py
index c101f59..19222ab 100644
--- a/src/webgwas_backend/main.py
+++ b/src/webgwas_backend/main.py
@@ -1,10 +1,13 @@
 import logging
 from collections.abc import Generator
+from contextlib import asynccontextmanager
+from functools import lru_cache
 from typing import Annotated
 
 import webgwas.phenotype_definitions
 from fastapi import Depends, FastAPI, HTTPException
 from fastapi.middleware.cors import CORSMiddleware
+from sqlalchemy import Engine
 from sqlmodel import Session, select
 from webgwas.phenotype_definitions import Field, KnowledgeBase
 
@@ -27,22 +30,35 @@
 from webgwas_backend.worker import Worker
 
 logger = logging.getLogger("uvicorn")
-logger.setLevel(logging.INFO)
+logger.setLevel(logging.DEBUG)
 
 init_db()
-worker_group = Worker(settings)
 
+worker: Worker | None = None
 
+
+@asynccontextmanager
+async def lifespan(app: FastAPI):  # noqa: ARG001
+    global worker
+    worker = Worker(settings)
+    yield
+
+
+@lru_cache(maxsize=1)
 def get_worker() -> Worker:
-    return worker_group
+    return Worker(settings)
+
+
+def get_engine() -> Engine:
+    return engine
 
 
-def get_session() -> Generator[Session]:
+def get_session(engine: Annotated[Engine, Depends(get_engine)]) -> Generator[Session]:
     with Session(engine) as session:
         yield session
 
 
-app = FastAPI()
+app = FastAPI(lifespan=lifespan)
 app.add_middleware(
     CORSMiddleware,
     allow_origins=["*"],
diff --git a/uv.lock b/uv.lock
index 18620ea..1e0fa09 100644
--- a/uv.lock
+++ b/uv.lock
@@ -29,30 +29,39 @@ wheels = [
 
 [[package]]
 name = "boto3"
-version = "1.35.7"
+version = "1.35.8"
 source = { registry = "https://pypi.org/simple" }
 dependencies = [
     { name = "botocore" },
     { name = "jmespath" },
     { name = "s3transfer" },
 ]
-sdist = { url = "https://files.pythonhosted.org/packages/59/d2/95729dcca737eccb19bfefdd9a2fa89beb9263e84e9543163349f7007090/boto3-1.35.7.tar.gz", hash = "sha256:05bd349cf260ba177924f38d721e427e2b3a6dd0fa8a18fa4ffc1b889633b181", size = 108623 }
+sdist = { url = "https://files.pythonhosted.org/packages/91/64/39a9c9c490ad4201a88a2f3339286eedb9200cf4868b3917c002aef02233/boto3-1.35.8.tar.gz", hash = "sha256:b9587131372a808bf6f99c5ed8b11be55cd113261cc3b437a917b4acc6c30bfe", size = 108616 }
 wheels = [
-    { url = "https://files.pythonhosted.org/packages/91/56/2b0c6e700c0ecf658399f78a9bdf3c5edb6be096c5e7ec13ed1bdbfd074c/boto3-1.35.7-py3-none-any.whl", hash = "sha256:bfbdf7c8f2e3eb70e4309cdcf5c9c7940e1fed4f645cdfb52581e7e67d3c8cab", size = 139143 },
+    { url = "https://files.pythonhosted.org/packages/d9/cd/db2b57967b189a5fa355887581457df008003671c41725d744ca8b8b507e/boto3-1.35.8-py3-none-any.whl", hash = "sha256:06eac4757de2a9c6020381205cb902f05964caad80b56e58c8931284a133b4cb", size = 139144 },
 ]
 
 [[package]]
 name = "botocore"
-version = "1.35.7"
+version = "1.35.8"
 source = { registry = "https://pypi.org/simple" }
 dependencies = [
     { name = "jmespath" },
     { name = "python-dateutil" },
     { name = "urllib3" },
 ]
-sdist = { url = "https://files.pythonhosted.org/packages/d1/2f/9da463c355b1f744223383c8efc817a6db1789341a842cfdbf1522840684/botocore-1.35.7.tar.gz", hash = "sha256:85e4b58f2c6e54dfbf52eaee72ebc9b70188fd1716d47f626874abadcee45512", size = 12687742 }
+sdist = { url = "https://files.pythonhosted.org/packages/00/cd/7d9250eb9734ce3c220178a63ad87ae4dd8019c1c48d48a7f014b84b9ead/botocore-1.35.8.tar.gz", hash = "sha256:4b820cf680ab5d778bd2fe4feeef1ff8a2b96d5c535d4638ab30f703ade282f8", size = 12700788 }
 wheels = [
-    { url = "https://files.pythonhosted.org/packages/d2/eb/ebe5bc70c3ab95f973410374c6a7c29e47d780f22185c21f13f2dad2e660/botocore-1.35.7-py3-none-any.whl", hash = "sha256:324e58518a92f2946bc6653e5e1272bc88d4b6313413f938bdc51cb90d34cbba", size = 12478086 },
+    { url = "https://files.pythonhosted.org/packages/6d/e4/62d781901fa1543f3274b259b15887e957927f3422e379f04244fae1accf/botocore-1.35.8-py3-none-any.whl", hash = "sha256:adf389eb8fd87775f193300e3431d1353f925807ad3a39958172cb644f0d60a1", size = 12491569 },
+]
+
+[[package]]
+name = "certifi"
+version = "2024.7.4"
+source = { registry = "https://pypi.org/simple" }
+sdist = { url = "https://files.pythonhosted.org/packages/c2/02/a95f2b11e207f68bc64d7aae9666fed2e2b3f307748d5123dffb72a1bbea/certifi-2024.7.4.tar.gz", hash = "sha256:5a1e7645bc0ec61a09e26c36f6106dd4cf40c6db3a1fb6352b0244e7fb057c7b", size = 164065 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/1c/d5/c84e1a17bf61d4df64ca866a1c9a913874b4e9bdc131ec689a0ad013fb36/certifi-2024.7.4-py3-none-any.whl", hash = "sha256:c198e21b1289c2ab85ee4e67bb4b4ef3ead0892059901a8d5b622f24a1101e90", size = 162960 },
 ]
 
 [[package]]
@@ -120,6 +129,15 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/cb/0a/4b33ba99394d900def8bd0a008d9f22eb2a0a93d58053621bbf052613cf0/connectorx-0.3.3-cp312-none-win_amd64.whl", hash = "sha256:a37762f26ced286e9c06528f0179877148ea83f24263ac53b906c33c430af323", size = 53816655 },
 ]
 
+[[package]]
+name = "dnspython"
+version = "2.6.1"
+source = { registry = "https://pypi.org/simple" }
+sdist = { url = "https://files.pythonhosted.org/packages/37/7d/c871f55054e403fdfd6b8f65fd6d1c4e147ed100d3e9f9ba1fe695403939/dnspython-2.6.1.tar.gz", hash = "sha256:e8f0f9c23a7b7cb99ded64e6c3a6f3e701d78f50c55e002b839dea7225cff7cc", size = 332727 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/87/a1/8c5287991ddb8d3e4662f71356d9656d91ab3a36618c3dd11b280df0d255/dnspython-2.6.1-py3-none-any.whl", hash = "sha256:5ef3b9680161f6fa89daf8ad451b5f1a33b18ae8a1c6778cdf4b43f08c0a6e50", size = 307696 },
+]
+
 [[package]]
 name = "dynaconf"
 version = "3.2.6"
@@ -129,6 +147,19 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/e2/14/c8a7d861262139688fa465d2e27ff7113764d6fa03b15b9c7b666729ea2e/dynaconf-3.2.6-py2.py3-none-any.whl", hash = "sha256:3911c740d717df4576ed55f616c7cbad6e06bc8ef23ffca444b6e2a12fb1c34c", size = 231063 },
 ]
 
+[[package]]
+name = "email-validator"
+version = "2.2.0"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "dnspython" },
+    { name = "idna" },
+]
+sdist = { url = "https://files.pythonhosted.org/packages/48/ce/13508a1ec3f8bb981ae4ca79ea40384becc868bfae97fd1c942bb3a001b1/email_validator-2.2.0.tar.gz", hash = "sha256:cb690f344c617a714f22e66ae771445a1ceb46821152df8e165c5f9a364582b7", size = 48967 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/d7/ee/bf0adb559ad3c786f12bcbc9296b3f5675f529199bef03e2df281fa1fadb/email_validator-2.2.0-py3-none-any.whl", hash = "sha256:561977c2d73ce3611850a06fa56b414621e0c8faa9d66f2611407d87465da631", size = 33521 },
+]
+
 [[package]]
 name = "fastapi"
 version = "0.112.2"
@@ -143,6 +174,34 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/5c/ae/6570ae1b67007735229f10f2e1174d6e33c056ee9c0c1754d432acbede94/fastapi-0.112.2-py3-none-any.whl", hash = "sha256:db84b470bd0e2b1075942231e90e3577e12a903c4dc8696f0d206a7904a7af1c", size = 93471 },
 ]
 
+[package.optional-dependencies]
+standard = [
+    { name = "email-validator" },
+    { name = "fastapi-cli", extra = ["standard"] },
+    { name = "httpx" },
+    { name = "jinja2" },
+    { name = "python-multipart" },
+    { name = "uvicorn", extra = ["standard"] },
+]
+
+[[package]]
+name = "fastapi-cli"
+version = "0.0.5"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "typer" },
+    { name = "uvicorn", extra = ["standard"] },
+]
+sdist = { url = "https://files.pythonhosted.org/packages/c5/f8/1ad5ce32d029aeb9117e9a5a9b3e314a8477525d60c12a9b7730a3c186ec/fastapi_cli-0.0.5.tar.gz", hash = "sha256:d30e1239c6f46fcb95e606f02cdda59a1e2fa778a54b64686b3ff27f6211ff9f", size = 15571 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/24/ea/4b5011012ac925fe2f83b19d0e09cee9d324141ec7bf5e78bb2817f96513/fastapi_cli-0.0.5-py3-none-any.whl", hash = "sha256:e94d847524648c748a5350673546bbf9bcaeb086b33c24f2e82e021436866a46", size = 9489 },
+]
+
+[package.optional-dependencies]
+standard = [
+    { name = "uvicorn", extra = ["standard"] },
+]
+
 [[package]]
 name = "greenlet"
 version = "3.0.3"
@@ -160,6 +219,59 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/53/80/3d94d5999b4179d91bcc93745d1b0815b073d61be79dd546b840d17adb18/greenlet-3.0.3-cp312-cp312-win_amd64.whl", hash = "sha256:bba5387a6975598857d86de9eac14210a49d554a77eb8261cc68b7d082f78ce2", size = 293635 },
 ]
 
+[[package]]
+name = "h11"
+version = "0.14.0"
+source = { registry = "https://pypi.org/simple" }
+sdist = { url = "https://files.pythonhosted.org/packages/f5/38/3af3d3633a34a3316095b39c8e8fb4853a28a536e55d347bd8d8e9a14b03/h11-0.14.0.tar.gz", hash = "sha256:8f19fbbe99e72420ff35c00b27a34cb9937e902a8b810e2c88300c6f0a3b699d", size = 100418 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/95/04/ff642e65ad6b90db43e668d70ffb6736436c7ce41fcc549f4e9472234127/h11-0.14.0-py3-none-any.whl", hash = "sha256:e3fe4ac4b851c468cc8363d500db52c2ead036020723024a109d37346efaa761", size = 58259 },
+]
+
+[[package]]
+name = "httpcore"
+version = "1.0.5"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "certifi" },
+    { name = "h11" },
+]
+sdist = { url = "https://files.pythonhosted.org/packages/17/b0/5e8b8674f8d203335a62fdfcfa0d11ebe09e23613c3391033cbba35f7926/httpcore-1.0.5.tar.gz", hash = "sha256:34a38e2f9291467ee3b44e89dd52615370e152954ba21721378a87b2960f7a61", size = 83234 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/78/d4/e5d7e4f2174f8a4d63c8897d79eb8fe2503f7ecc03282fee1fa2719c2704/httpcore-1.0.5-py3-none-any.whl", hash = "sha256:421f18bac248b25d310f3cacd198d55b8e6125c107797b609ff9b7a6ba7991b5", size = 77926 },
+]
+
+[[package]]
+name = "httptools"
+version = "0.6.1"
+source = { registry = "https://pypi.org/simple" }
+sdist = { url = "https://files.pythonhosted.org/packages/67/1d/d77686502fced061b3ead1c35a2d70f6b281b5f723c4eff7a2277c04e4a2/httptools-0.6.1.tar.gz", hash = "sha256:c6e26c30455600b95d94b1b836085138e82f177351454ee841c148f93a9bad5a", size = 191228 }
+wheels = [
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+]
+
+[[package]]
+name = "httpx"
+version = "0.27.2"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "anyio" },
+    { name = "certifi" },
+    { name = "httpcore" },
+    { name = "idna" },
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-version = "0.1.15"
-source = { git = "https://github.com/zietzm/webgwas.git#ce28b63bc097f501e417020d795955ab4ba59be7" }
+version = "0.2.0"
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 dependencies = [
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     { name = "numpy" },
     { name = "pandas" },
+    { name = "polars" },
     { name = "pydantic" },
 ]
 
@@ -631,7 +950,7 @@ dependencies = [
     { name = "botocore" },
     { name = "connectorx" },
     { name = "dynaconf" },
-    { name = "fastapi" },
+    { name = "fastapi", extra = ["standard"] },
     { name = "pandas" },
     { name = "polars" },
     { name = "pyarrow" },
@@ -645,13 +964,20 @@ dependencies = [
     { name = "zstandard" },
 ]
 
+[package.dev-dependencies]
+dev = [
+    { name = "httpx" },
+    { name = "pytest" },
+    { name = "ruff" },
+]
+
 [package.metadata]
 requires-dist = [
     { name = "boto3", specifier = ">=1.34.145" },
     { name = "botocore", specifier = ">=1.34.145" },
     { name = "connectorx", specifier = ">=0.3.3" },
     { name = "dynaconf", specifier = ">=3.2.6" },
-    { name = "fastapi", specifier = ">=0.111.0" },
+    { name = "fastapi", extras = ["standard"], specifier = ">=0.111.0" },
     { name = "pandas", specifier = ">=2.2.2" },
     { name = "polars", specifier = ">=1.3.0" },
     { name = "pyarrow", specifier = ">=17.0.0" },
@@ -665,6 +991,44 @@ requires-dist = [
     { name = "zstandard", specifier = ">=0.23.0" },
 ]
 
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+    { name = "pytest", specifier = ">=8.3.2" },
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