diff --git a/Cargo.lock b/Cargo.lock
index 7bae1fa9..a635ca49 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -853,6 +853,15 @@ dependencies = [
  "bitflags",
 ]
 
+[[package]]
+name = "codegen"
+version = "0.1.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "34c59e8a9b988977ec3bd61ab380cf1167048817ecd3d6999fac03657f85a609"
+dependencies = [
+ "indexmap",
+]
+
 [[package]]
 name = "combine"
 version = "3.8.1"
@@ -2040,6 +2049,17 @@ dependencies = [
  "winapi 0.3.8",
 ]
 
+[[package]]
+name = "isbn2"
+version = "0.4.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "32ec02acd9e12bee98c320d8ff9fe1c8882174067ac7932866f7ad7bf5309cd8"
+dependencies = [
+ "arrayvec 0.5.2",
+ "codegen",
+ "roxmltree",
+]
+
 [[package]]
 name = "itertools"
 version = "0.9.0"
@@ -3291,6 +3311,15 @@ dependencies = [
  "winapi 0.3.8",
 ]
 
+[[package]]
+name = "roxmltree"
+version = "0.13.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dbf7d7b1ea646d380d0e8153158063a6da7efe30ddbf3184042848e3f8a6f671"
+dependencies = [
+ "xmlparser",
+]
+
 [[package]]
 name = "rust-argon2"
 version = "0.8.3"
@@ -3934,6 +3963,7 @@ dependencies = [
  "diesel_migrations",
  "dotenv",
  "futures 0.3.5",
+ "isbn2",
  "jsonwebtoken",
  "juniper",
  "lazy_static 1.4.0",
@@ -4841,6 +4871,12 @@ version = "0.8.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "541b12c998c5b56aa2b4e6f18f03664eef9a4fd0a246a55594efae6cc2d964b5"
 
+[[package]]
+name = "xmlparser"
+version = "0.13.3"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "114ba2b24d2167ef6d67d7d04c8cc86522b87f490025f39f0303b7db5bf5e3d8"
+
 [[package]]
 name = "yaml-rust"
 version = "0.4.4"
diff --git a/thoth-api/Cargo.toml b/thoth-api/Cargo.toml
index 42e2106d..5477a8dc 100644
--- a/thoth-api/Cargo.toml
+++ b/thoth-api/Cargo.toml
@@ -19,6 +19,7 @@ backend = ["diesel", "diesel-derive-enum", "diesel_migrations", "futures", "acti
 thoth-errors = { version = "0.4.1", path = "../thoth-errors" }
 actix-web = { version = "3.3.2", optional = true }
 argon2rs = "0.2.5"
+isbn2 = "0.4.0"
 chrono = { version = "0.4", features = ["serde"] }
 diesel = { version = "1.4.0", features = ["postgres", "uuidv07", "chrono", "r2d2", "64-column-tables", "serde_json"], optional = true }
 diesel-derive-enum = { version = "1.1.0", features = ["postgres"], optional = true }
diff --git a/thoth-api/src/graphql/model.rs b/thoth-api/src/graphql/model.rs
index e8df777d..51e846e8 100644
--- a/thoth-api/src/graphql/model.rs
+++ b/thoth-api/src/graphql/model.rs
@@ -16,6 +16,7 @@ use crate::issue::model::*;
 use crate::language::model::*;
 use crate::model::Crud;
 use crate::model::Doi;
+use crate::model::Isbn;
 use crate::model::Orcid;
 use crate::model::Timestamp;
 use crate::price::model::*;
@@ -1805,7 +1806,7 @@ impl Publication {
         self.work_id
     }
 
-    pub fn isbn(&self) -> Option<&String> {
+    pub fn isbn(&self) -> Option<&Isbn> {
         self.isbn.as_ref()
     }
 
diff --git a/thoth-api/src/model/mod.rs b/thoth-api/src/model/mod.rs
index b97c8473..0c0ad028 100644
--- a/thoth-api/src/model/mod.rs
+++ b/thoth-api/src/model/mod.rs
@@ -1,4 +1,5 @@
 use chrono::{DateTime, TimeZone, Utc};
+use isbn2::Isbn13;
 use serde::{Deserialize, Serialize};
 use std::fmt;
 use std::str::FromStr;
@@ -19,6 +20,16 @@ pub const ORCID_DOMAIN: &str = "https://orcid.org/";
 #[derive(Debug, Clone, Serialize, Deserialize, PartialEq)]
 pub struct Doi(String);
 
+#[cfg_attr(
+    feature = "backend",
+    derive(DieselNewType, juniper::GraphQLScalarValue),
+    graphql(
+        description = "13-digit International Standard Book Number, with its parts separated by hyphens"
+    )
+)]
+#[derive(Debug, Clone, Serialize, Deserialize, PartialEq)]
+pub struct Isbn(String);
+
 #[cfg_attr(
     feature = "backend",
     derive(DieselNewType, juniper::GraphQLScalarValue),
@@ -43,6 +54,12 @@ impl Default for Doi {
     }
 }
 
+impl Default for Isbn {
+    fn default() -> Isbn {
+        Isbn(Default::default())
+    }
+}
+
 impl Default for Orcid {
     fn default() -> Orcid {
         Orcid(Default::default())
@@ -61,6 +78,12 @@ impl fmt::Display for Doi {
     }
 }
 
+impl fmt::Display for Isbn {
+    fn fmt(&self, f: &mut fmt::Formatter) -> fmt::Result {
+        write!(f, "{}", &self.0)
+    }
+}
+
 impl fmt::Display for Orcid {
     fn fmt(&self, f: &mut fmt::Formatter) -> fmt::Result {
         write!(f, "{}", &self.0.replace(ORCID_DOMAIN, ""))
@@ -108,6 +131,24 @@ impl FromStr for Doi {
     }
 }
 
+impl FromStr for Isbn {
+    type Err = ThothError;
+
+    fn from_str(input: &str) -> ThothResult<Isbn> {
+        if input.is_empty() {
+            Err(ThothError::IsbnEmptyError)
+        } else {
+            match input.parse::<Isbn13>() {
+                Ok(parsed) => match parsed.hyphenate() {
+                    Ok(hyphenated) => Ok(Isbn(hyphenated.to_string())),
+                    Err(_) => Err(ThothError::IsbnParseError(input.to_string())),
+                },
+                Err(_) => Err(ThothError::IsbnParseError(input.to_string())),
+            }
+        }
+    }
+}
+
 impl FromStr for Orcid {
     type Err = ThothError;
 
@@ -372,6 +413,12 @@ fn test_doi_default() {
     assert_eq!(doi, Doi("".to_string()));
 }
 
+#[test]
+fn test_isbn_default() {
+    let isbn: Isbn = Default::default();
+    assert_eq!(isbn, Isbn("".to_string()));
+}
+
 #[test]
 fn test_orcid_default() {
     let orcid: Orcid = Default::default();
@@ -390,6 +437,12 @@ fn test_doi_display() {
     assert_eq!(format!("{}", doi), "10.12345/Test-Suffix.01");
 }
 
+#[test]
+fn test_isbn_display() {
+    let isbn = Isbn("978-3-16-148410-0".to_string());
+    assert_eq!(format!("{}", isbn), "978-3-16-148410-0");
+}
+
 #[test]
 fn test_orcid_display() {
     let orcid = Orcid("https://orcid.org/0000-0002-1234-5678".to_string());
@@ -475,6 +528,30 @@ fn test_doi_fromstr() {
     assert!(Doi::from_str("10.https://doi.org/12345/Test-Suffix.01").is_err());
 }
 
+#[test]
+fn test_isbn_fromstr() {
+    // Note the `isbn2` crate contains tests of valid/invalid ISBN values -
+    // this focuses on testing that a valid ISBN in any format is standardised
+    let standardised = Isbn("978-3-16-148410-0".to_string());
+    assert_eq!(Isbn::from_str("978-3-16-148410-0").unwrap(), standardised);
+    assert_eq!(Isbn::from_str("9783161484100").unwrap(), standardised);
+    assert_eq!(Isbn::from_str("978 3 16 148410 0").unwrap(), standardised);
+    assert_eq!(Isbn::from_str("978 3 16-148410-0").unwrap(), standardised);
+    assert_eq!(Isbn::from_str("9-7-831614-8-4-100").unwrap(), standardised);
+    assert_eq!(
+        Isbn::from_str("   97831    614 84  100    ").unwrap(),
+        standardised
+    );
+    assert_eq!(
+        Isbn::from_str("---97--831614----8-4100--").unwrap(),
+        standardised
+    );
+    assert!(Isbn::from_str("978-3-16-148410-1").is_err());
+    assert!(Isbn::from_str("1234567890123").is_err());
+    assert!(Isbn::from_str("0-684-84328-5").is_err());
+    assert!(Isbn::from_str("abcdef").is_err());
+}
+
 #[test]
 fn test_orcid_fromstr() {
     let standardised = Orcid("https://orcid.org/0000-0002-1234-5678".to_string());
diff --git a/thoth-api/src/publication/model.rs b/thoth-api/src/publication/model.rs
index 4b359082..1f9013d6 100644
--- a/thoth-api/src/publication/model.rs
+++ b/thoth-api/src/publication/model.rs
@@ -4,6 +4,7 @@ use strum::EnumString;
 use uuid::Uuid;
 
 use crate::graphql::utils::Direction;
+use crate::model::Isbn;
 use crate::model::Timestamp;
 use crate::price::model::Price;
 #[cfg(feature = "backend")]
@@ -65,7 +66,7 @@ pub struct Publication {
     pub publication_id: Uuid,
     pub publication_type: PublicationType,
     pub work_id: Uuid,
-    pub isbn: Option<String>,
+    pub isbn: Option<Isbn>,
     pub publication_url: Option<String>,
     pub created_at: Timestamp,
     pub updated_at: Timestamp,
@@ -77,7 +78,7 @@ pub struct PublicationWithRelations {
     pub publication_id: Uuid,
     pub publication_type: PublicationType,
     pub work_id: Uuid,
-    pub isbn: Option<String>,
+    pub isbn: Option<Isbn>,
     pub publication_url: Option<String>,
     pub updated_at: Timestamp,
     pub prices: Option<Vec<Price>>,
@@ -92,7 +93,7 @@ pub struct PublicationWithRelations {
 pub struct NewPublication {
     pub publication_type: PublicationType,
     pub work_id: Uuid,
-    pub isbn: Option<String>,
+    pub isbn: Option<Isbn>,
     pub publication_url: Option<String>,
 }
 
@@ -106,7 +107,7 @@ pub struct PatchPublication {
     pub publication_id: Uuid,
     pub publication_type: PublicationType,
     pub work_id: Uuid,
-    pub isbn: Option<String>,
+    pub isbn: Option<Isbn>,
     pub publication_url: Option<String>,
 }
 
diff --git a/thoth-app/src/component/publication.rs b/thoth-app/src/component/publication.rs
index deeba261..7c5649c4 100644
--- a/thoth-app/src/component/publication.rs
+++ b/thoth-app/src/component/publication.rs
@@ -145,7 +145,8 @@ impl Component for PublicationComponent {
                                 format!(
                                     "Deleted {}",
                                     &p.isbn
-                                        .clone()
+                                        .as_ref()
+                                        .map(|s| s.to_string())
                                         .unwrap_or_else(|| p.publication_id.to_string())
                                 ),
                                 NotificationStatus::Success,
@@ -236,7 +237,7 @@ impl Component for PublicationComponent {
                             <div class="field">
                                 <label class="label">{ "ISBN" }</label>
                                 <div class="control is-expanded">
-                                    {&self.publication.isbn.clone().unwrap_or_else(|| "".to_string())}
+                                    {&self.publication.isbn.as_ref().map(|s| s.to_string()).unwrap_or_else(|| "".to_string())}
                                 </div>
                             </div>
 
diff --git a/thoth-app/src/component/publications_form.rs b/thoth-app/src/component/publications_form.rs
index 407c9fa1..b468d28e 100644
--- a/thoth-app/src/component/publications_form.rs
+++ b/thoth-app/src/component/publications_form.rs
@@ -1,6 +1,8 @@
 use std::str::FromStr;
+use thoth_api::model::Isbn;
 use thoth_api::publication::model::Publication;
 use thoth_api::publication::model::PublicationType;
+use thoth_errors::ThothError;
 use uuid::Uuid;
 use yew::html;
 use yew::prelude::*;
@@ -19,7 +21,7 @@ use crate::agent::notification_bus::NotificationDispatcher;
 use crate::agent::notification_bus::NotificationStatus;
 use crate::agent::notification_bus::Request;
 use crate::component::utils::FormPublicationTypeSelect;
-use crate::component::utils::FormTextInput;
+use crate::component::utils::FormTextInputExtended;
 use crate::component::utils::FormUrlInput;
 use crate::models::publication::create_publication_mutation::CreatePublicationRequest;
 use crate::models::publication::create_publication_mutation::CreatePublicationRequestBody;
@@ -45,6 +47,9 @@ pub struct PublicationsFormComponent {
     props: Props,
     data: PublicationsFormData,
     new_publication: Publication,
+    // Track the user-entered ISBN string, which may not be validly formatted
+    isbn: String,
+    isbn_warning: String,
     show_add_form: bool,
     fetch_publication_types: FetchPublicationTypes,
     push_publication: PushCreatePublication,
@@ -89,6 +94,8 @@ impl Component for PublicationsFormComponent {
         let data: PublicationsFormData = Default::default();
         let show_add_form = false;
         let new_publication: Publication = Default::default();
+        let isbn = Default::default();
+        let isbn_warning = Default::default();
         let push_publication = Default::default();
         let delete_publication = Default::default();
         let notification_bus = NotificationBus::dispatcher();
@@ -100,6 +107,8 @@ impl Component for PublicationsFormComponent {
             props,
             data,
             new_publication,
+            isbn,
+            isbn_warning,
             show_add_form,
             fetch_publication_types: Default::default(),
             push_publication,
@@ -114,6 +123,12 @@ impl Component for PublicationsFormComponent {
         match msg {
             Msg::ToggleAddFormDisplay(value) => {
                 self.show_add_form = value;
+                // Ensure ISBN variables are cleared on re-opening form,
+                // otherwise a previously-entered valid ISBN value may be
+                // saved although an invalid value was subsequently entered
+                self.new_publication.isbn = Default::default();
+                self.isbn = Default::default();
+                self.isbn_warning = Default::default();
                 true
             }
             Msg::SetPublicationTypesFetchState(fetch_state) => {
@@ -170,6 +185,14 @@ impl Component for PublicationsFormComponent {
                 }
             }
             Msg::CreatePublication => {
+                // Only update the ISBN value with the current user-entered string
+                // if it is validly formatted - otherwise keep the default.
+                // If no ISBN was provided, no format check is required.
+                if self.isbn.is_empty() {
+                    self.new_publication.isbn.neq_assign(None);
+                } else if let Ok(result) = self.isbn.parse::<Isbn>() {
+                    self.new_publication.isbn.neq_assign(Some(result));
+                }
                 let body = CreatePublicationRequestBody {
                     variables: Variables {
                         work_id: self.props.work_id,
@@ -241,11 +264,25 @@ impl Component for PublicationsFormComponent {
                 self.new_publication.publication_type.neq_assign(val)
             }
             Msg::ChangeIsbn(value) => {
-                let isbn = match value.trim().is_empty() {
-                    true => None,
-                    false => Some(value.trim().to_owned()),
-                };
-                self.new_publication.isbn.neq_assign(isbn)
+                if self.isbn.neq_assign(value.trim().to_owned()) {
+                    // If ISBN is not correctly formatted, display a warning.
+                    // Don't update self.new_publication.isbn yet, as user may later
+                    // overwrite a new valid value with an invalid one.
+                    self.isbn_warning.clear();
+                    match self.isbn.parse::<Isbn>() {
+                        Err(e) => {
+                            match e {
+                                // If no ISBN was provided, no warning is required.
+                                ThothError::IsbnEmptyError => {}
+                                _ => self.isbn_warning = e.to_string(),
+                            }
+                        }
+                        Ok(value) => self.isbn = value.to_string(),
+                    }
+                    true
+                } else {
+                    false
+                }
             }
             Msg::ChangeUrl(value) => {
                 let url = match value.trim().is_empty() {
@@ -322,9 +359,10 @@ impl Component for PublicationsFormComponent {
                                     })
                                     required = true
                                 />
-                                <FormTextInput
+                                <FormTextInputExtended
                                     label = "ISBN"
-                                    value=self.new_publication.isbn.clone().unwrap_or_else(|| "".to_string()).clone()
+                                    value=self.isbn.clone()
+                                    tooltip=self.isbn_warning.clone()
                                     oninput=self.link.callback(|e: InputData| Msg::ChangeIsbn(e.value))
                                 />
                                 <FormUrlInput
@@ -396,7 +434,7 @@ impl PublicationsFormComponent {
                     <div class="field" style="width: 8em;">
                         <label class="label">{ "ISBN" }</label>
                         <div class="control is-expanded">
-                            {&p.isbn.clone().unwrap_or_else(|| "".to_string())}
+                            {&p.isbn.as_ref().map(|s| s.to_string()).unwrap_or_else(|| "".to_string())}
                         </div>
                     </div>
 
diff --git a/thoth-app/src/models/publication/create_publication_mutation.rs b/thoth-app/src/models/publication/create_publication_mutation.rs
index 7e286883..2b292d7b 100644
--- a/thoth-app/src/models/publication/create_publication_mutation.rs
+++ b/thoth-app/src/models/publication/create_publication_mutation.rs
@@ -1,5 +1,6 @@
 use serde::Deserialize;
 use serde::Serialize;
+use thoth_api::model::Isbn;
 use thoth_api::publication::model::Publication;
 use thoth_api::publication::model::PublicationType;
 use uuid::Uuid;
@@ -8,7 +9,7 @@ const CREATE_PUBLICATION_MUTATION: &str = "
     mutation CreatePublication(
         $publicationType: PublicationType!,
         $workId: Uuid!,
-        $isbn: String,
+        $isbn: Isbn,
         $publicationUrl: String,
     ) {
         createPublication(data: {
@@ -44,7 +45,7 @@ graphql_query_builder! {
 pub struct Variables {
     pub publication_type: PublicationType,
     pub work_id: Uuid,
-    pub isbn: Option<String>,
+    pub isbn: Option<Isbn>,
     pub publication_url: Option<String>,
 }
 
diff --git a/thoth-app/src/models/publication/delete_publication_mutation.rs b/thoth-app/src/models/publication/delete_publication_mutation.rs
index 61e200e1..82e49353 100644
--- a/thoth-app/src/models/publication/delete_publication_mutation.rs
+++ b/thoth-app/src/models/publication/delete_publication_mutation.rs
@@ -13,6 +13,7 @@ const DELETE_PUBLICATION_MUTATION: &str = "
             publicationId
             publicationType
             workId
+            isbn
             createdAt
             updatedAt
         }
diff --git a/thoth-app/src/models/publication/mod.rs b/thoth-app/src/models/publication/mod.rs
index a58626b4..e9f11a3c 100644
--- a/thoth-app/src/models/publication/mod.rs
+++ b/thoth-app/src/models/publication/mod.rs
@@ -38,7 +38,11 @@ impl EditRoute for PublicationWithRelations {
 
 impl MetadataTable for PublicationWithRelations {
     fn as_table_row(&self, callback: Callback<MouseEvent>) -> Html {
-        let isbn = &self.isbn.clone().unwrap_or_else(|| "".to_string());
+        let isbn = self
+            .isbn
+            .as_ref()
+            .map(|s| s.to_string())
+            .unwrap_or_else(|| "".to_string());
         let doi = self
             .work
             .doi
diff --git a/thoth-errors/src/lib.rs b/thoth-errors/src/lib.rs
index 507bc030..45b1633f 100644
--- a/thoth-errors/src/lib.rs
+++ b/thoth-errors/src/lib.rs
@@ -42,10 +42,17 @@ pub enum ThothError {
         _0
     )]
     DoiParseError(String),
+    #[fail(
+        display = "{} is not a validly formatted ISBN and will not be saved",
+        _0
+    )]
+    IsbnParseError(String),
     #[fail(display = "Cannot parse ORCID: no value provided")]
     OrcidEmptyError,
     #[fail(display = "Cannot parse DOI: no value provided")]
     DoiEmptyError,
+    #[fail(display = "Cannot parse ISBN: no value provided")]
+    IsbnEmptyError,
 }
 
 #[cfg(not(target_arch = "wasm32"))]