diff --git a/cdc/kv/client.go b/cdc/kv/client.go
index a58403d3067..6a4ace59ab4 100644
--- a/cdc/kv/client.go
+++ b/cdc/kv/client.go
@@ -1105,16 +1105,14 @@ func (s *eventFeedSession) receiveFromStream(
 	for {
 		cevent, err := stream.Recv()
 
-		failpoint.Inject("kvClientStreamRecvError", func() {
-			err = errors.New("injected stream recv error")
-		})
-		// TODO: Should we have better way to handle the errors?
-		if err == io.EOF {
-			for _, state := range regionStates {
-				close(state.regionEventCh)
+		failpoint.Inject("kvClientStreamRecvError", func(msg failpoint.Value) {
+			errStr := msg.(string)
+			if errStr == io.EOF.Error() {
+				err = io.EOF
+			} else {
+				err = errors.New(errStr)
 			}
-			return nil
-		}
+		})
 		if err != nil {
 			if status.Code(errors.Cause(err)) == codes.Canceled {
 				log.Debug(
@@ -1402,12 +1400,8 @@ func (s *eventFeedSession) singleEventFeed(
 			continue
 		case event, ok = <-receiverCh:
 		}
-		if !ok {
-			log.Debug("singleEventFeed receiver closed")
-			return lastResolvedTs, nil
-		}
 
-		if event == nil {
+		if !ok || event == nil {
 			log.Debug("singleEventFeed closed by error")
 			return lastResolvedTs, cerror.ErrEventFeedAborted.GenWithStackByArgs()
 		}
diff --git a/cdc/kv/client_test.go b/cdc/kv/client_test.go
index e82d9581bbb..fd99c17e251 100644
--- a/cdc/kv/client_test.go
+++ b/cdc/kv/client_test.go
@@ -1193,11 +1193,7 @@ func (s *etcdSuite) TestStreamSendWithError(c *check.C) {
 	cancel()
 }
 
-// TestStreamSendWithError mainly tests the scenario that the `Recv` call of a gPRC
-// stream in kv client meets error, and kv client logs the error and re-establish
-// new request
-func (s *etcdSuite) TestStreamRecvWithError(c *check.C) {
-	defer testleak.AfterTest(c)()
+func (s *etcdSuite) testStreamRecvWithError(c *check.C, failpointStr string) {
 	defer s.TearDownTest(c)
 	ctx, cancel := context.WithCancel(context.Background())
 	wg := &sync.WaitGroup{}
@@ -1226,7 +1222,7 @@ func (s *etcdSuite) TestStreamRecvWithError(c *check.C) {
 	cluster.AddStore(1, addr1)
 	cluster.Bootstrap(regionID, []uint64{1}, []uint64{4}, 4)
 
-	err = failpoint.Enable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError", "1*return(true)")
+	err = failpoint.Enable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError", failpointStr)
 	c.Assert(err, check.IsNil)
 	defer func() {
 		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError")
@@ -1316,6 +1312,42 @@ func (s *etcdSuite) TestStreamRecvWithError(c *check.C) {
 	cancel()
 }
 
+// TestStreamSendWithErrorNormal mainly tests the scenario that the `Recv` call
+// of a gPRC stream in kv client meets a **logical related** error, and kv client
+// logs the error and re-establish new request.
+func (s *etcdSuite) TestStreamRecvWithErrorNormal(c *check.C) {
+	defer testleak.AfterTest(c)()
+
+	// test client v2
+	s.testStreamRecvWithError(c, "1*return(\"injected stream recv error\")")
+
+	// test client v1
+	clientv2 := enableKVClientV2
+	enableKVClientV2 = false
+	defer func() {
+		enableKVClientV2 = clientv2
+	}()
+	s.testStreamRecvWithError(c, "1*return(\"injected stream recv error\")")
+}
+
+// TestStreamSendWithErrorIOEOF mainly tests the scenario that the `Recv` call
+// of a gPRC stream in kv client meets error io.EOF, and kv client logs the error
+// and re-establish new request
+func (s *etcdSuite) TestStreamRecvWithErrorIOEOF(c *check.C) {
+	defer testleak.AfterTest(c)()
+
+	// test client v2
+	s.testStreamRecvWithError(c, "1*return(\"EOF\")")
+
+	// test client v1
+	clientv2 := enableKVClientV2
+	enableKVClientV2 = false
+	defer func() {
+		enableKVClientV2 = clientv2
+	}()
+	s.testStreamRecvWithError(c, "1*return(\"EOF\")")
+}
+
 // TestIncompatibleTiKV tests TiCDC new request to TiKV meets `ErrVersionIncompatible`
 // error (in fact this error is raised before EventFeed API is really called),
 // TiCDC will wait 20s and then retry. This is a common scenario when rolling
@@ -2351,8 +2383,8 @@ func (s *etcdSuite) TestFailRegionReentrant(c *check.C) {
 	err = failpoint.Enable("github.com/pingcap/ticdc/cdc/kv/kvClientRegionReentrantErrorDelay", "sleep(500)")
 	c.Assert(err, check.IsNil)
 	defer func() {
-		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError")
-		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvErrorDelay")
+		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientRegionReentrantError")
+		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientRegionReentrantErrorDelay")
 	}()
 	baseAllocatedID := currentRequestID()
 	lockresolver := txnutil.NewLockerResolver(kvStorage.(tikv.Storage))
@@ -2387,3 +2419,80 @@ func (s *etcdSuite) TestFailRegionReentrant(c *check.C) {
 	time.Sleep(time.Second)
 	cancel()
 }
+<<<<<<< HEAD
+=======
+
+// TestClientV1UnlockRangeReentrant tests clientV1 can handle region reconnection
+// with unstable TiKV store correctly. The test workflow is as follows:
+// 1. kv client establishes two regions request, naming region-1, region-2, they
+//    belong to the same TiKV store.
+// 2. The region-1 is firstly established, yet region-2 has some delay after its
+//    region state is inserted into `pendingRegions`
+// 3. At this time the TiKV store crashes and `stream.Recv` returns error. In the
+//    defer function of `receiveFromStream`, all pending regions will be cleaned
+//    up, which means the region lock will be unlocked once for these regions.
+// 4. In step-2, the region-2 continues to run, it can't get store stream which
+//    has been deleted in step-3, so it will create new stream but fails because
+//    of unstable TiKV store, at this point, the kv client should handle with the
+//    pending region correctly.
+func (s *etcdSuite) TestClientV1UnlockRangeReentrant(c *check.C) {
+	defer testleak.AfterTest(c)()
+	defer s.TearDownTest(c)
+
+	clientv2 := enableKVClientV2
+	enableKVClientV2 = false
+	defer func() {
+		enableKVClientV2 = clientv2
+	}()
+
+	ctx, cancel := context.WithCancel(context.Background())
+	wg := &sync.WaitGroup{}
+
+	ch1 := make(chan *cdcpb.ChangeDataEvent, 10)
+	srv1 := newMockChangeDataService(c, ch1)
+	server1, addr1 := newMockService(ctx, c, srv1, wg)
+
+	rpcClient, cluster, pdClient, err := mocktikv.NewTiKVAndPDClient("")
+	c.Assert(err, check.IsNil)
+	pdClient = &mockPDClient{Client: pdClient, versionGen: defaultVersionGen}
+	tiStore, err := tikv.NewTestTiKVStore(rpcClient, pdClient, nil, nil, 0)
+	c.Assert(err, check.IsNil)
+	kvStorage := newStorageWithCurVersionCache(tiStore, addr1)
+	defer kvStorage.Close() //nolint:errcheck
+
+	regionID3 := uint64(3)
+	regionID4 := uint64(4)
+	cluster.AddStore(1, addr1)
+	cluster.Bootstrap(regionID3, []uint64{1}, []uint64{4}, 4)
+	cluster.SplitRaw(regionID3, regionID4, []byte("b"), []uint64{5}, 5)
+
+	err = failpoint.Enable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError", "1*return(\"injected stream recv error\")")
+	c.Assert(err, check.IsNil)
+	err = failpoint.Enable("github.com/pingcap/ticdc/cdc/kv/kvClientPendingRegionDelay", "1*sleep(0)->1*sleep(2000)")
+	c.Assert(err, check.IsNil)
+	defer func() {
+		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientStreamRecvError")
+		_ = failpoint.Disable("github.com/pingcap/ticdc/cdc/kv/kvClientPendingRegionDelay")
+	}()
+	lockresolver := txnutil.NewLockerResolver(kvStorage)
+	isPullInit := &mockPullerInit{}
+	cdcClient := NewCDCClient(ctx, pdClient, kvStorage, &security.Credential{})
+	eventCh := make(chan *model.RegionFeedEvent, 10)
+	wg.Add(1)
+	go func() {
+		err := cdcClient.EventFeed(ctx, regionspan.ComparableSpan{Start: []byte("a"), End: []byte("c")}, 100, false, lockresolver, isPullInit, eventCh)
+		c.Assert(errors.Cause(err), check.Equals, context.Canceled)
+		cdcClient.Close() //nolint:errcheck
+		wg.Done()
+	}()
+
+	// wait the second region is scheduled
+	time.Sleep(time.Millisecond * 500)
+	close(ch1)
+	server1.Stop()
+	// wait the kvClientPendingRegionDelay ends, and the second region is processed
+	time.Sleep(time.Second * 2)
+	cancel()
+	wg.Wait()
+}
+>>>>>>> 000eb0f... kv/client: fix the error handling for io.EOF may miss region reconnect (#1641)
diff --git a/cdc/kv/client_v2.go b/cdc/kv/client_v2.go
index 625ff1ce8db..0e46abc057f 100644
--- a/cdc/kv/client_v2.go
+++ b/cdc/kv/client_v2.go
@@ -210,13 +210,14 @@ func (s *eventFeedSession) receiveFromStreamV2(
 				worker.inputCh <- nil
 			}
 		})
-		failpoint.Inject("kvClientStreamRecvError", func() {
-			err = errors.New("injected stream recv error")
+		failpoint.Inject("kvClientStreamRecvError", func(msg failpoint.Value) {
+			errStr := msg.(string)
+			if errStr == io.EOF.Error() {
+				err = io.EOF
+			} else {
+				err = errors.New(errStr)
+			}
 		})
-		if err == io.EOF {
-			close(worker.inputCh)
-			return nil
-		}
 		if err != nil {
 			if status.Code(errors.Cause(err)) == codes.Canceled {
 				log.Debug(
diff --git a/cdc/kv/region_worker.go b/cdc/kv/region_worker.go
index 76176862dd6..6309ee376a2 100644
--- a/cdc/kv/region_worker.go
+++ b/cdc/kv/region_worker.go
@@ -267,13 +267,9 @@ func (w *regionWorker) eventHandler(ctx context.Context) error {
 		case <-ctx.Done():
 			return errors.Trace(ctx.Err())
 		case event, ok := <-w.inputCh:
-			if !ok {
-				log.Debug("region worker receiver closed")
-				return nil
-			}
 			// event == nil means the region worker should exit and re-establish
 			// all existing regions.
-			if event == nil {
+			if !ok || event == nil {
 				log.Info("region worker closed by error")
 				return w.evictAllRegions(ctx)
 			}