diff --git a/packages/opentelemetry-instrumentation-anthropic/opentelemetry/instrumentation/anthropic/__init__.py b/packages/opentelemetry-instrumentation-anthropic/opentelemetry/instrumentation/anthropic/__init__.py
index 7d39f4257..a79e8ac33 100644
--- a/packages/opentelemetry-instrumentation-anthropic/opentelemetry/instrumentation/anthropic/__init__.py
+++ b/packages/opentelemetry-instrumentation-anthropic/opentelemetry/instrumentation/anthropic/__init__.py
@@ -148,6 +148,20 @@ def _set_response_attributes(span, response):
     if not isinstance(response, dict):
         response = response.__dict__
     _set_span_attribute(span, SpanAttributes.LLM_RESPONSE_MODEL, response.get("model"))
+
+    if response.get("usage"):
+        prompt_tokens = response.get("usage").input_tokens
+        completion_tokens = response.get("usage").output_tokens
+        _set_span_attribute(span, SpanAttributes.LLM_USAGE_PROMPT_TOKENS, prompt_tokens)
+        _set_span_attribute(
+            span, SpanAttributes.LLM_USAGE_COMPLETION_TOKENS, completion_tokens
+        )
+        _set_span_attribute(
+            span,
+            SpanAttributes.LLM_USAGE_TOTAL_TOKENS,
+            prompt_tokens + completion_tokens,
+        )
+
     if should_send_prompts():
         _set_span_completions(span, response)
 
diff --git a/packages/opentelemetry-instrumentation-anthropic/tests/test_completion.py b/packages/opentelemetry-instrumentation-anthropic/tests/test_completion.py
index 62ba8b49e..284f43456 100644
--- a/packages/opentelemetry-instrumentation-anthropic/tests/test_completion.py
+++ b/packages/opentelemetry-instrumentation-anthropic/tests/test_completion.py
@@ -53,6 +53,12 @@ def test_anthropic_message_create(exporter):
         anthropic_span.attributes.get("llm.completions.0.content")
         == response.content[0].text
     )
+    assert anthropic_span.attributes["llm.usage.prompt_tokens"] == 8
+    assert (
+        anthropic_span.attributes["llm.usage.completion_tokens"]
+        + anthropic_span.attributes["llm.usage.prompt_tokens"]
+        == anthropic_span.attributes["llm.usage.total_tokens"]
+    )
 
 
 @pytest.mark.vcr
@@ -104,3 +110,9 @@ def test_anthropic_multi_modal(exporter):
         anthropic_span.attributes.get("llm.completions.0.content")
         == response.content[0].text
     )
+    assert anthropic_span.attributes["llm.usage.prompt_tokens"] == 1381
+    assert (
+        anthropic_span.attributes["llm.usage.completion_tokens"]
+        + anthropic_span.attributes["llm.usage.prompt_tokens"]
+        == anthropic_span.attributes["llm.usage.total_tokens"]
+    )