diff --git a/lib/galaxy/tools/errors.py b/lib/galaxy/tools/errors.py
index da55ef82eaed..38ebccf5e3f2 100644
--- a/lib/galaxy/tools/errors.py
+++ b/lib/galaxy/tools/errors.py
@@ -253,6 +253,13 @@ def _send_report(self, user, email=None, message=None, **kwd):
         except Exception:
             pass
 
+        reply_to = user.email if user else None
         return util.send_mail(
-            self.app.config.email_from, to, subject, self.report, self.app.config, html=self.html_report
+            self.app.config.email_from,
+            to,
+            subject,
+            self.report,
+            self.app.config,
+            html=self.html_report,
+            reply_to=reply_to,
         )
diff --git a/lib/galaxy/util/__init__.py b/lib/galaxy/util/__init__.py
index 20c113861ae1..0f954b3b700a 100644
--- a/lib/galaxy/util/__init__.py
+++ b/lib/galaxy/util/__init__.py
@@ -1506,7 +1506,7 @@ def size_to_bytes(size):
         raise ValueError(f"Unknown multiplier '{multiple}' in '{size}'")
 
 
-def send_mail(frm, to, subject, body, config, html=None):
+def send_mail(frm, to, subject, body, config, html=None, reply_to=None):
     """
     Sends an email.
 
@@ -1527,7 +1527,10 @@ def send_mail(frm, to, subject, body, config, html=None):
 
     :type  html: str
     :param html: Alternative HTML representation of the body content. If
-                 provided will convert the message to a MIMEMultipart. (Default 'None')
+                 provided will convert the message to a MIMEMultipart. (Default None)
+
+    :type  reply_to: str
+    :param reply_to: Reply-to address (Default None)
     """
 
     to = listify(to)
@@ -1540,6 +1543,9 @@ def send_mail(frm, to, subject, body, config, html=None):
     msg["From"] = frm
     msg["Subject"] = subject
 
+    if reply_to:
+        msg["Reply-To"] = reply_to
+
     if config.smtp_server is None:
         log.error("Mail is not configured for this Galaxy instance.")
         log.info(msg)