diff --git a/crates/mako/src/build/transform.rs b/crates/mako/src/build/transform.rs
index 66b1b668b..a406f7c99 100644
--- a/crates/mako/src/build/transform.rs
+++ b/crates/mako/src/build/transform.rs
@@ -49,6 +49,7 @@ use crate::visitors::try_resolve::TryResolve;
 use crate::visitors::ts_strip::ts_strip;
 use crate::visitors::tsx_strip::tsx_strip;
 use crate::visitors::virtual_css_modules::VirtualCSSModules;
+use crate::visitors::webpack_runtime_replacement::WebpackRuntimeReplacement;
 use crate::visitors::worker_module::WorkerModule;
 
 pub struct Transform {}
@@ -111,6 +112,7 @@ impl Transform {
                                         unresolved_mark,
                                     }),
                                     Box::new(WorkerModule::new(unresolved_mark)),
+                                    Box::new(WebpackRuntimeReplacement::new(unresolved_mark)),
                                 ];
 
                                 // named default export
diff --git a/crates/mako/src/visitors.rs b/crates/mako/src/visitors.rs
index 1faca4174..0d40cb6a4 100644
--- a/crates/mako/src/visitors.rs
+++ b/crates/mako/src/visitors.rs
@@ -28,4 +28,5 @@ pub(crate) mod try_resolve;
 pub(crate) mod ts_strip;
 pub(crate) mod tsx_strip;
 pub(crate) mod virtual_css_modules;
+pub(crate) mod webpack_runtime_replacement;
 pub(crate) mod worker_module;
diff --git a/crates/mako/src/visitors/webpack_runtime_replacement.rs b/crates/mako/src/visitors/webpack_runtime_replacement.rs
new file mode 100644
index 000000000..17d7c6131
--- /dev/null
+++ b/crates/mako/src/visitors/webpack_runtime_replacement.rs
@@ -0,0 +1,88 @@
+use swc_core::common::{Mark, DUMMY_SP};
+use swc_core::ecma::ast::{Expr, Ident, UnaryExpr};
+use swc_core::ecma::visit::{VisitMut, VisitMutWith};
+
+pub const WEBPACK_VALUES: [&str; 14] = [
+    "__webpack_get_script_filename__",
+    "__webpack_runtime_id__",
+    "__webpack_chunkname__",
+    "__webpack_nonce__",
+    "__webpack_init_sharing__",
+    "__webpack_share_scopes__",
+    "__system_context__",
+    "__non_webpack_require__",
+    "__webpack_require__",
+    "__webpack_hash__",
+    "__webpack_modules__",
+    "__webpack_module__",
+    "__webpack_chunk_load__",
+    "__webpack_base_uri__",
+];
+
+pub struct WebpackRuntimeReplacement {
+    pub unresolved_mark: Mark,
+}
+
+impl WebpackRuntimeReplacement {
+    pub fn new(unresolved_mark: Mark) -> Self {
+        Self { unresolved_mark }
+    }
+    fn is_ident_webpack(&self, ident: &Ident, unresolved_mark: &Mark) -> bool {
+        WEBPACK_VALUES.iter().any(|&i| i == &ident.sym) && ident.ctxt.outer() == *unresolved_mark
+    }
+}
+
+impl VisitMut for WebpackRuntimeReplacement {
+    // find the "typeof __webpack_require__" in the ast tree
+    fn visit_mut_unary_expr(&mut self, unary_expr: &mut UnaryExpr) {
+        if unary_expr.op.as_str() == "typeof"
+            && let Some(arg_ident) = unary_expr.arg.as_ident()
+            && self.is_ident_webpack(arg_ident, &self.unresolved_mark)
+        {
+            unary_expr.arg = Expr::undefined(DUMMY_SP)
+        } else {
+            unary_expr.visit_mut_children_with(self);
+        }
+    }
+}
+
+#[cfg(test)]
+mod tests {
+    use swc_core::common::GLOBALS;
+    use swc_core::ecma::visit::VisitMutWith;
+
+    use super::WebpackRuntimeReplacement;
+    use crate::ast::tests::TestUtils;
+
+    #[test]
+    fn test_webpack_require_ident() {
+        assert_eq!(
+            run(r#"typeof __webpack_require__ === 'function';"#),
+            r#"typeof void 0 === 'function';"#
+        );
+    }
+
+    #[test]
+    fn test_webpack_module_ident() {
+        assert_eq!(run(r#"typeof __webpack_modules__;"#), r#"typeof void 0;"#);
+    }
+    #[test]
+    fn test_dbcheck_webpack_module_ident() {
+        assert_eq!(
+            run(r#"typeof typeof __webpack_modules__;"#),
+            r#"typeof typeof void 0;"#
+        );
+    }
+
+    fn run(js_code: &str) -> String {
+        let mut test_utils = TestUtils::gen_js_ast(js_code);
+        let ast = test_utils.ast.js_mut();
+        GLOBALS.set(&test_utils.context.meta.script.globals, || {
+            let mut visitor = WebpackRuntimeReplacement {
+                unresolved_mark: ast.unresolved_mark,
+            };
+            ast.ast.visit_mut_with(&mut visitor);
+        });
+        test_utils.js_ast_to_code()
+    }
+}