diff --git a/readme.md b/readme.md
index 7cff3195..f2c2119c 100644
--- a/readme.md
+++ b/readme.md
@@ -42,12 +42,18 @@ export default () => (
 )
 ```
 
+### Options
+
+* `sourceMaps` generates source maps (default: `false`)
+* `vendorPrefix` turn on/off automatic vendor prefixing (default: `true`)
+
 ## Features
 
 - Full CSS support, no tradeoffs in power
 - Runtime size of just **2kb** (gzipped, from 6kb)
 - Complete isolation: Selectors, animations, keyframes
 - Built-in CSS vendor prefixing
+- CSS Preprocessing via Plugins
 - Very fast, minimal and efficient transpilation (see below)
 - High-performance runtime-CSS-injection when not server-rendering
 - Future-proof: Equivalent to server-renderable "Shadow CSS"
@@ -113,6 +119,82 @@ module.exports = `div { color: green; }`
 // module.exports = { styles: `div { color: green; }` }
 ```
 
+### CSS Preprocessing via Plugins
+
+Styles can be preprocessed via plugins.
+
+Plugins are regular JavaScript modules that export a simple function with the following signature:
+
+```js
+(css: string, settings: Object) => string
+```
+
+Basically they accept a CSS string in input, optionally modify it and finally return it.
+
+Plugins make it possible to use popular preprocessors like SASS, Less, Stylus, PostCSS or apply custom transformations to the styles.
+
+To register a plugin add an option `plugins` for `styled-jsx/babel` to your `.babelrc`. `plugins` must be an array of module names or *full* paths for local plugins.
+
+```json
+{
+  "plugins": [
+    [
+      "styled-jsx/babel",
+      { "plugins": ["my-styled-jsx-plugin-package", "/full/path/to/local/plugin"] }
+    ]
+  ]
+}
+```
+
+In order to resolve local plugins paths you can use NodeJS' [require.resolve](https://nodejs.org/api/globals.html#globals_require_resolve).
+
+Plugins are applied in definition order left to right before styles are scoped.
+
+N.B. when applying the plugins styled-jsx replaces template literals expressions with placeholders e.g. `%%styledjsxexpression_ExprNumber%%` because otherwise CSS parsers would get invalid CSS.
+
+#### Plugin options and settings
+
+Users can set plugin options by registering a plugin as an array that contains
+the plugin path and an options object.
+
+```json
+{
+  "plugins": [
+    [
+      "styled-jsx/babel",
+      {
+        "plugins": [
+          ["my-styled-jsx-plugin-package", { "exampleOption":  true }]
+        ],
+        "sourceMaps": true
+      }
+    ]
+  ]
+}
+```
+
+Each plugin receives a `settings` object as second argument which contains
+the babel and user options:
+
+```js
+(css, settings) => { /* ... */ }
+```
+
+The `settings` object has the following shape:
+
+```js
+{
+  // babel options
+  sourceMaps: true,
+  vendorPrefix: true,
+
+  // user options
+  options: {
+    exampleOption: true
+  }
+}
+```
+
 ### Targeting The Root
 
 Notice that the parent `<div>` above also gets a `data-jsx` attribute. We do this so that
diff --git a/src/_utils.js b/src/_utils.js
index e33467e8..c18d8f7c 100644
--- a/src/_utils.js
+++ b/src/_utils.js
@@ -258,3 +258,52 @@ export const addSourceMaps = (code, generator, filename) =>
     convert.fromObject(generator).toComment({ multiline: true }),
     `/*@ sourceURL=${filename} */`
   ].join('\n')
+
+export const combinePlugins = (plugins, opts) => {
+  if (!plugins) {
+    return css => css
+  }
+
+  if (
+    !Array.isArray(plugins) ||
+    plugins.some(p => !Array.isArray(p) && typeof p !== 'string')
+  ) {
+    throw new Error(
+      '`plugins` must be an array of plugins names (string) or an array `[plugin-name, {options}]`'
+    )
+  }
+
+  return plugins
+    .map((plugin, i) => {
+      let options = {}
+      if (Array.isArray(plugin)) {
+        options = plugin[1] || {}
+        plugin = plugin[0]
+      }
+
+      // eslint-disable-next-line import/no-dynamic-require
+      let p = require(plugin)
+      if (p.default) {
+        p = p.default
+      }
+
+      const type = typeof p
+      if (type !== 'function') {
+        throw new Error(
+          `Expected plugin ${plugins[i]} to be a function but instead got ${type}`
+        )
+      }
+      return {
+        plugin: p,
+        settings: {
+          ...opts,
+          options
+        }
+      }
+    })
+    .reduce(
+      (previous, { plugin, settings }) => css =>
+        plugin(previous ? previous(css) : css, settings),
+      null
+    )
+}
diff --git a/src/babel-external.js b/src/babel-external.js
index 14aecac9..c4bcc1b4 100644
--- a/src/babel-external.js
+++ b/src/babel-external.js
@@ -9,9 +9,11 @@ import {
   makeStyledJsxCss,
   isValidCss,
   makeSourceMapGenerator,
-  addSourceMaps
+  addSourceMaps,
+  combinePlugins
 } from './_utils'
 
+let plugins
 const getCss = (path, validate = false) => {
   if (!path.isTemplateLiteral() && !path.isStringLiteral()) {
     return
@@ -24,7 +26,6 @@ const getCss = (path, validate = false) => {
 }
 
 const getStyledJsx = (css, opts, path) => {
-  const useSourceMaps = Boolean(opts.sourceMaps)
   const commonHash = hash(css.modified || css)
   const globalHash = `1${commonHash}`
   const scopedHash = `2${commonHash}`
@@ -34,16 +35,17 @@ const getStyledJsx = (css, opts, path) => {
   const prefix = `[${MARKUP_ATTRIBUTE_EXTERNAL}~="${scopedHash}"]`
   const isTemplateLiteral = Boolean(css.modified)
 
-  if (useSourceMaps) {
+  if (opts.sourceMaps) {
     const generator = makeSourceMapGenerator(opts.file)
     const filename = opts.sourceFileName
     const offset = path.get('loc').node.start
     compiledCss = [/* global */ '', prefix].map(prefix =>
       addSourceMaps(
-        transform(prefix, css.modified || css, {
+        transform(prefix, opts.plugins(css.modified || css), {
           generator,
           offset,
-          filename
+          filename,
+          vendorPrefix: opts.vendorPrefix
         }),
         generator,
         filename
@@ -51,7 +53,9 @@ const getStyledJsx = (css, opts, path) => {
     )
   } else {
     compiledCss = ['', prefix].map(prefix =>
-      transform(prefix, css.modified || css)
+      transform(prefix, opts.plugins(css.modified || css), {
+        vendorPrefix: opts.vendorPrefix
+      })
     )
   }
   globalCss = compiledCss[0]
@@ -156,15 +160,28 @@ const callVisitor = (visitor, path, state) => {
   const { opts } = file
   visitor(path, {
     validate: state.opts.validate || opts.validate,
-    sourceMaps: opts.sourceMaps,
+    sourceMaps: state.opts.sourceMaps || opts.sourceMaps,
     sourceFileName: opts.sourceFileName,
-    file
+    file,
+    plugins,
+    vendorPrefix: state.opts.vendorPrefix
   })
 }
 
 export default function() {
   return {
     visitor: {
+      Program(path, state) {
+        if (!plugins) {
+          const { sourceMaps, vendorPrefix } = state.opts
+          plugins = combinePlugins(state.opts.plugins, {
+            sourceMaps: sourceMaps || state.file.opts.sourceMaps,
+            vendorPrefix: typeof vendorPrefix === 'boolean'
+              ? vendorPrefix
+              : true
+          })
+        }
+      },
       ExportDefaultDeclaration(path, state) {
         callVisitor(exportDefaultDeclarationVisitor, path, state)
       },
diff --git a/src/babel.js b/src/babel.js
index c90c55af..d4c8e37a 100644
--- a/src/babel.js
+++ b/src/babel.js
@@ -20,7 +20,8 @@ import {
   validateExpression,
   generateAttribute,
   makeSourceMapGenerator,
-  addSourceMaps
+  addSourceMaps,
+  combinePlugins
 } from './_utils'
 
 import {
@@ -29,15 +30,18 @@ import {
   MARKUP_ATTRIBUTE_EXTERNAL
 } from './_constants'
 
+let plugins
 const getPrefix = id => `[${MARKUP_ATTRIBUTE}="${id}"]`
 const callExternalVisitor = (visitor, path, state) => {
   const { file } = state
   const { opts } = file
   visitor(path, {
     validate: true,
-    sourceMaps: opts.sourceMaps,
+    sourceMaps: state.opts.sourceMaps || opts.sourceMaps,
     sourceFileName: opts.sourceFileName,
-    file
+    file,
+    plugins,
+    vendorPrefix: state.opts.vendorPrefix
   })
 }
 
@@ -292,7 +296,9 @@ export default function({ types: t }) {
           // We replace styles with the function call
           const [id, css, loc] = state.styles.shift()
 
-          const useSourceMaps = Boolean(state.file.opts.sourceMaps)
+          const useSourceMaps = Boolean(
+            state.opts.sourceMaps || state.file.opts.sourceMaps
+          )
           let transformedCss
 
           if (useSourceMaps) {
@@ -301,11 +307,12 @@ export default function({ types: t }) {
             transformedCss = addSourceMaps(
               transform(
                 isGlobal ? '' : getPrefix(state.jsxId),
-                css.modified || css,
+                plugins(css.modified || css),
                 {
                   generator,
                   offset: loc.start,
-                  filename
+                  filename,
+                  vendorPrefix: state.opts.vendorPrefix
                 }
               ),
               generator,
@@ -314,7 +321,10 @@ export default function({ types: t }) {
           } else {
             transformedCss = transform(
               isGlobal ? '' : getPrefix(state.jsxId),
-              css.modified || css
+              plugins(css.modified || css),
+              {
+                vendorPrefix: state.opts.vendorPrefix
+              }
             )
           }
 
@@ -334,6 +344,15 @@ export default function({ types: t }) {
           state.ignoreClosing = null
           state.file.hasJSXStyle = false
           state.imports = []
+          if (!plugins) {
+            const { sourceMaps, vendorPrefix } = state.opts
+            plugins = combinePlugins(state.opts.plugins, {
+              sourceMaps: sourceMaps || state.file.opts.sourceMaps,
+              vendorPrefix: typeof vendorPrefix === 'boolean'
+                ? vendorPrefix
+                : true
+            })
+          }
         },
         exit({ node, scope }, state) {
           if (!(state.file.hasJSXStyle && !scope.hasBinding(STYLE_COMPONENT))) {
diff --git a/src/lib/style-transform.js b/src/lib/style-transform.js
index 16a542d0..679cea8e 100644
--- a/src/lib/style-transform.js
+++ b/src/lib/style-transform.js
@@ -82,6 +82,11 @@ function transform(prefix, styles, settings = {}) {
   generator = settings.generator
   offset = settings.offset
   filename = settings.filename
+  stylis.set({
+    prefix: typeof settings.vendorPrefix === 'boolean'
+      ? settings.vendorPrefix
+      : true
+  })
 
   return stylis(prefix, styles)
 }
diff --git a/test/__snapshots__/index.js.snap b/test/__snapshots__/index.js.snap
index 3c632c15..2040f3aa 100644
--- a/test/__snapshots__/index.js.snap
+++ b/test/__snapshots__/index.js.snap
@@ -1,5 +1,23 @@
 // Jest Snapshot v1, https://goo.gl/fbAQLP
 
+exports[`generates source maps (babel options) 1`] = `
+"import _JSXStyle from 'styled-jsx/style';
+export default (() => <div data-jsx={188072295}>
+    <p data-jsx={188072295}>test</p>
+    <p data-jsx={188072295}>woot</p>
+    <_JSXStyle styleId={188072295} css={\\"p[data-jsx=\\\\\\"188072295\\\\\\"]{color:red}\\\\n/*# sourceMappingURL=data:application/json;base64,eyJ2ZXJzaW9uIjozLCJzb3VyY2VzIjpbInNvdXJjZS1tYXBzLmpzIl0sIm5hbWVzIjpbXSwibWFwcGluZ3MiOiJBQUlnQixBQUNjLFdBQUMiLCJmaWxlIjoic291cmNlLW1hcHMuanMiLCJzb3VyY2VzQ29udGVudCI6WyJleHBvcnQgZGVmYXVsdCAoKSA9PiAoXG4gIDxkaXY+XG4gICAgPHA+dGVzdDwvcD5cbiAgICA8cD53b290PC9wPlxuICAgIDxzdHlsZSBqc3g+eydwIHsgY29sb3I6IHJlZCB9J308L3N0eWxlPlxuICA8L2Rpdj5cbilcbiJdfQ== */\\\\n/*@ sourceURL=source-maps.js */\\"} />
+  </div>);"
+`;
+
+exports[`generates source maps (plugin options) 1`] = `
+"import _JSXStyle from 'styled-jsx/style';
+export default (() => <div data-jsx={188072295}>
+    <p data-jsx={188072295}>test</p>
+    <p data-jsx={188072295}>woot</p>
+    <_JSXStyle styleId={188072295} css={\\"p[data-jsx=\\\\\\"188072295\\\\\\"]{color:red}\\\\n/*# sourceMappingURL=data:application/json;base64,eyJ2ZXJzaW9uIjozLCJzb3VyY2VzIjpbInNvdXJjZS1tYXBzLmpzIl0sIm5hbWVzIjpbXSwibWFwcGluZ3MiOiJBQUlnQixBQUNjLFdBQUMiLCJmaWxlIjoic291cmNlLW1hcHMuanMiLCJzb3VyY2VzQ29udGVudCI6WyJleHBvcnQgZGVmYXVsdCAoKSA9PiAoXG4gIDxkaXY+XG4gICAgPHA+dGVzdDwvcD5cbiAgICA8cD53b290PC9wPlxuICAgIDxzdHlsZSBqc3g+eydwIHsgY29sb3I6IHJlZCB9J308L3N0eWxlPlxuICA8L2Rpdj5cbilcbiJdfQ== */\\\\n/*@ sourceURL=source-maps.js */\\"} />
+  </div>);"
+`;
+
 exports[`generates source maps 1`] = `
 "import _JSXStyle from 'styled-jsx/style';
 export default (() => <div data-jsx={188072295}>
diff --git a/test/__snapshots__/plugins.js.snap b/test/__snapshots__/plugins.js.snap
new file mode 100644
index 00000000..d99457c3
--- /dev/null
+++ b/test/__snapshots__/plugins.js.snap
@@ -0,0 +1,13 @@
+// Jest Snapshot v1, https://goo.gl/fbAQLP
+
+exports[`applies plugins 1`] = `
+"import _JSXStyle from 'styled-jsx/style';
+import styles from './styles';
+const color = 'red';
+
+export default (() => <div data-jsx={4216192053} data-jsx-ext={styles.__scopedHash}>
+    <p data-jsx={4216192053} data-jsx-ext={styles.__scopedHash}>test</p>
+    <_JSXStyle styleId={4216192053} css={\`span.\${color}[data-jsx=\\"4216192053\\"]{color:\${otherColor}}\`} />
+    <_JSXStyle styleId={styles.__scopedHash} css={styles.__scoped} />
+  </div>);"
+`;
diff --git a/test/fixtures/plugins/another-plugin.js b/test/fixtures/plugins/another-plugin.js
new file mode 100644
index 00000000..c90c5381
--- /dev/null
+++ b/test/fixtures/plugins/another-plugin.js
@@ -0,0 +1 @@
+export default css => css.replace(/div/g, 'span')
diff --git a/test/fixtures/plugins/invalid-plugin.js b/test/fixtures/plugins/invalid-plugin.js
new file mode 100644
index 00000000..aa3b6937
--- /dev/null
+++ b/test/fixtures/plugins/invalid-plugin.js
@@ -0,0 +1 @@
+export default 'invalid'
diff --git a/test/fixtures/plugins/options.js b/test/fixtures/plugins/options.js
new file mode 100644
index 00000000..d0c4376d
--- /dev/null
+++ b/test/fixtures/plugins/options.js
@@ -0,0 +1 @@
+export default (css, settings) => settings.options.test
diff --git a/test/fixtures/plugins/plugin.js b/test/fixtures/plugins/plugin.js
new file mode 100644
index 00000000..ca989db6
--- /dev/null
+++ b/test/fixtures/plugins/plugin.js
@@ -0,0 +1 @@
+export default css => `TEST (${css}) EOTEST`
diff --git a/test/fixtures/with-plugins.js b/test/fixtures/with-plugins.js
new file mode 100644
index 00000000..29f8ace3
--- /dev/null
+++ b/test/fixtures/with-plugins.js
@@ -0,0 +1,10 @@
+import styles from './styles'
+const color = 'red'
+
+export default () => (
+  <div>
+    <p>test</p>
+    <style jsx>{`div.${color} { color: ${otherColor} }`}</style>
+    <style jsx>{styles}</style>
+  </div>
+)
diff --git a/test/fixtures/with-plugins.out.js b/test/fixtures/with-plugins.out.js
new file mode 100644
index 00000000..4b5c861a
--- /dev/null
+++ b/test/fixtures/with-plugins.out.js
@@ -0,0 +1,9 @@
+import _JSXStyle from 'styled-jsx/style';
+import styles from './styles';
+const color = 'red';
+
+export default (() => <div data-jsx={4216192053} data-jsx-ext={styles.__scopedHash}>
+    <p data-jsx={4216192053} data-jsx-ext={styles.__scopedHash}>test</p>
+    <_JSXStyle styleId={4216192053} css={`span.${color}[data-jsx="4216192053"] {color: ${otherColor}}`} />
+    <_JSXStyle styleId={styles.__scopedHash} css={styles.__scoped} />
+  </div>);
diff --git a/test/index.js b/test/index.js
index 905a9b77..52668f5c 100644
--- a/test/index.js
+++ b/test/index.js
@@ -40,13 +40,20 @@ test('works with global styles', async t => {
   t.snapshot(code)
 })
 
-test('generates source maps', async t => {
+test('generates source maps (babel options)', async t => {
   const { code } = await transform('./fixtures/source-maps.js', {
     sourceMaps: true
   })
   t.snapshot(code)
 })
 
+test('generates source maps (plugin options)', async t => {
+  const { code } = await _transform('./fixtures/source-maps.js', {
+    plugins: [[plugin, { sourceMaps: true }]]
+  })
+  t.snapshot(code)
+})
+
 test('mixed global and scoped', async t => {
   const { code } = await transform('./fixtures/mixed-global-scoped.js')
   t.snapshot(code)
diff --git a/test/plugins.js b/test/plugins.js
new file mode 100644
index 00000000..09e9956e
--- /dev/null
+++ b/test/plugins.js
@@ -0,0 +1,80 @@
+// Packages
+import test from 'ava'
+
+// Ours
+import babelPlugin from '../src/babel'
+import { combinePlugins } from '../src/_utils'
+import _transform from './_transform'
+import testPlugin1 from './fixtures/plugins/plugin'
+import testPlugin2 from './fixtures/plugins/another-plugin'
+
+const transform = (file, opts = {}) =>
+  _transform(file, {
+    plugins: [
+      [
+        babelPlugin,
+        { plugins: [require.resolve('./fixtures/plugins/another-plugin')] }
+      ]
+    ],
+    ...opts
+  })
+
+test('combinePlugins returns an identity function when plugins is undefined', t => {
+  const test = 'test'
+  const plugins = combinePlugins()
+  t.is(plugins(test), test)
+})
+
+test('combinePlugins throws if plugins is not an array', t => {
+  t.throws(() => {
+    combinePlugins(2)
+  })
+})
+
+test('combinePlugins throws if plugins is not an array of strings', t => {
+  t.throws(() => {
+    combinePlugins(['test', 2])
+  })
+})
+
+test('combinePlugins throws if loaded plugins are not functions', t => {
+  t.throws(() => {
+    combinePlugins([
+      require.resolve('./fixtures/plugins/plugin'),
+      require.resolve('./fixtures/plugins/invalid-plugin')
+    ])
+  })
+})
+
+test('combinePlugins works with a single plugin', t => {
+  const plugins = combinePlugins([require.resolve('./fixtures/plugins/plugin')])
+
+  t.is(testPlugin1('test'), plugins('test'))
+})
+
+test('combinePlugins works with options', t => {
+  const expectedOption = 'my-test'
+  const plugins = combinePlugins([
+    [
+      require.resolve('./fixtures/plugins/options'),
+      {
+        test: expectedOption
+      }
+    ]
+  ])
+  t.is(plugins(''), expectedOption)
+})
+
+test('combinePlugins applies plugins left to right', t => {
+  const plugins = combinePlugins([
+    require.resolve('./fixtures/plugins/plugin'),
+    require.resolve('./fixtures/plugins/another-plugin')
+  ])
+
+  t.is(testPlugin2(testPlugin1('test')), plugins('test'))
+})
+
+test('applies plugins', async t => {
+  const { code } = await transform('./fixtures/with-plugins.js')
+  t.snapshot(code)
+})