diff --git a/packages/vite/src/node/__tests__/plugins/css.spec.ts b/packages/vite/src/node/__tests__/plugins/css.spec.ts
index d206e5b73e90d1..75d1c61060789b 100644
--- a/packages/vite/src/node/__tests__/plugins/css.spec.ts
+++ b/packages/vite/src/node/__tests__/plugins/css.spec.ts
@@ -272,7 +272,8 @@ import "other-module";`
     expect(replaced.length).toBe(code.length)
     expect(replaced).toMatchInlineSnapshot(`
       "import \\"some-module\\";
-      /* empty css              */import \\"other-module\\";"
+      /* empty css             */
+      import \\"other-module\\";"
     `)
   })
 
@@ -298,7 +299,8 @@ require("other-module");`
     expect(replaced.length).toBe(code.length)
     expect(replaced).toMatchInlineSnapshot(`
       "require(\\"some-module\\");
-      /* empty css                */require(\\"other-module\\");"
+      ;/* empty css              */
+      require(\\"other-module\\");"
     `)
   })
 
@@ -309,7 +311,30 @@ require("other-module");`
     const replaced = replacer(code)
     expect(replaced.length).toBe(code.length)
     expect(replaced).toMatchInlineSnapshot(
-      '"require(\\"some-module\\");/* empty css               */require(\\"other-module\\");"',
+      '"require(\\"some-module\\");;/* empty css              */require(\\"other-module\\");"',
+    )
+  })
+
+  test('replaces require call in minified code that uses comma operator', () => {
+    const code =
+      'require("some-module"),require("pure_css_chunk.js"),require("other-module");'
+
+    const replacer = getEmptyChunkReplacer(['pure_css_chunk.js'], 'cjs')
+    const newCode = replacer(code)
+    expect(newCode).toMatchInlineSnapshot(
+      '"require(\\"some-module\\"),/* empty css               */require(\\"other-module\\");"',
+    )
+    // So there should be no pure css chunk anymore
+    expect(newCode.match(/pure_css_chunk\.js/)).toBeNull()
+  })
+
+  test('replaces require call in minified code that uses comma operator followed by assignment', () => {
+    const code =
+      'require("some-module"),require("pure_css_chunk.js");const v=require("other-module");'
+
+    const replacer = getEmptyChunkReplacer(['pure_css_chunk.js'], 'cjs')
+    expect(replacer(code)).toMatchInlineSnapshot(
+      '"require(\\"some-module\\");/* empty css               */const v=require(\\"other-module\\");"',
     )
   })
 })
diff --git a/packages/vite/src/node/plugins/css.ts b/packages/vite/src/node/plugins/css.ts
index 638c336fda74ed..cb8dbbdae2188f 100644
--- a/packages/vite/src/node/plugins/css.ts
+++ b/packages/vite/src/node/plugins/css.ts
@@ -828,10 +828,13 @@ export function getEmptyChunkReplacer(
     .join('|')
     .replace(/\./g, '\\.')
 
+  // for cjs, require calls might be chained by minifier using the comma operator.
+  // in this case we have to keep one comma if a next require is chained
+  // or add a semicolon to terminate the chain.
   const emptyChunkRE = new RegExp(
     outputFormat === 'es'
-      ? `\\bimport\\s*["'][^"']*(?:${emptyChunkFiles})["'];\n?`
-      : `\\brequire\\(\\s*["'][^"']*(?:${emptyChunkFiles})["']\\);\n?`,
+      ? `\\bimport\\s*["'][^"']*(?:${emptyChunkFiles})["'];`
+      : `(\\b|,\\s*)require\\(\\s*["'][^"']*(?:${emptyChunkFiles})["']\\)(;|,)`,
     'g',
   )
 
@@ -839,7 +842,10 @@ export function getEmptyChunkReplacer(
     code.replace(
       emptyChunkRE,
       // remove css import while preserving source map location
-      (m) => `/* empty css ${''.padEnd(m.length - 15)}*/`,
+      (m) =>
+        outputFormat === 'es'
+          ? `/* empty css ${''.padEnd(m.length - 15)}*/`
+          : `${m.at(-1)}/* empty css ${''.padEnd(m.length - 16)}*/`,
     )
 }