diff --git a/src/node/build/buildPluginReplace.ts b/src/node/build/buildPluginReplace.ts
index 64df2fb9738029..b727050af7a143 100644
--- a/src/node/build/buildPluginReplace.ts
+++ b/src/node/build/buildPluginReplace.ts
@@ -1,9 +1,8 @@
 import { Plugin, TransformResult } from 'rollup'
 import MagicString from 'magic-string'
 
-const filter = /\.(j|t)sx?$/
-
 export const createReplacePlugin = (
+  test: (id: string) => boolean,
   replacements: Record<string, string>,
   sourcemap: boolean
 ): Plugin => {
@@ -21,7 +20,7 @@ export const createReplacePlugin = (
   return {
     name: 'vite:replace',
     transform(code, id) {
-      if (filter.test(id)) {
+      if (test(id)) {
         const s = new MagicString(code)
         let hasReplaced = false
         let match
diff --git a/src/node/build/index.ts b/src/node/build/index.ts
index dc91779bf5e2ae..283b0545e95886 100644
--- a/src/node/build/index.ts
+++ b/src/node/build/index.ts
@@ -3,7 +3,13 @@ import fs from 'fs-extra'
 import chalk from 'chalk'
 import { Ora } from 'ora'
 import { resolveFrom } from '../utils'
-import { rollup as Rollup, RollupOutput, ExternalOption, Plugin } from 'rollup'
+import {
+  rollup as Rollup,
+  RollupOutput,
+  ExternalOption,
+  Plugin,
+  InputOptions
+} from 'rollup'
 import { createResolver, supportedExts, InternalResolver } from '../resolver'
 import { createBuildResolvePlugin } from './buildPluginResolve'
 import { createBuildHtmlPlugin } from './buildPluginHtml'
@@ -37,6 +43,14 @@ const writeColors = {
   [WriteType.SOURCE_MAP]: chalk.gray
 }
 
+const warningIgnoreList = [`CIRCULAR_DEPENDENCY`, `THIS_IS_UNDEFINED`]
+
+export const onRollupWarning: InputOptions['onwarn'] = (warning, warn) => {
+  if (!warningIgnoreList.includes(warning.code!)) {
+    warn(warning)
+  }
+}
+
 /**
  * Named exports detection logic from Snowpack
  * MIT License
@@ -204,11 +218,7 @@ export async function build(options: BuildConfig = {}): Promise<BuildResult> {
     input: path.resolve(root, 'index.html'),
     preserveEntrySignatures: false,
     treeshake: { moduleSideEffects: 'no-external' },
-    onwarn(warning, warn) {
-      if (warning.code !== 'CIRCULAR_DEPENDENCY') {
-        warn(warning)
-      }
-    },
+    onwarn: onRollupWarning,
     ...rollupInputOptions,
     plugins: [
       ...basePlugins,
@@ -219,10 +229,19 @@ export async function build(options: BuildConfig = {}): Promise<BuildResult> {
       // - which makes it impossible to exclude Vue templates from it since
       // Vue templates are compiled into js and included in chunks.
       createReplacePlugin(
+        (id) => /\.(j|t)sx?$/.test(id),
         {
           ...envReplacements,
-          'process.env.': `({}).`,
-          __DEV__: 'false',
+          'process.env.': `({}).`
+        },
+        sourcemap
+      ),
+      // for vite spcific replacements, make sure to only apply them to
+      // non-dependency code to avoid collision (e.g. #224 antd has __DEV__)
+      createReplacePlugin(
+        (id) => !id.includes('node_modules') && /\.(j|t)sx?$/.test(id),
+        {
+          __DEV__: `false`,
           __BASE__: JSON.stringify(publicBasePath)
         },
         sourcemap
diff --git a/src/node/depOptimizer.ts b/src/node/depOptimizer.ts
index 6594c5dcefc25f..7307284aefb7d0 100644
--- a/src/node/depOptimizer.ts
+++ b/src/node/depOptimizer.ts
@@ -8,7 +8,7 @@ import {
   supportedExts,
   resolveNodeModuleEntry
 } from './resolver'
-import { createBaseRollupPlugins } from './build'
+import { createBaseRollupPlugins, onRollupWarning } from './build'
 import { resolveFrom, lookupFile } from './utils'
 import { init, parse } from 'es-module-lexer'
 import chalk from 'chalk'
@@ -214,16 +214,11 @@ export async function optimizeDeps(
     }, {} as Record<string, string>)
 
     const rollup = require('rollup') as typeof Rollup
-    const warningIgnoreList = [`CIRCULAR_DEPENDENCY`, `THIS_IS_UNDEFINED`]
     const bundle = await rollup.rollup({
       input,
       external: preservedDeps,
       treeshake: { moduleSideEffects: 'no-external' },
-      onwarn(warning, warn) {
-        if (!warningIgnoreList.includes(warning.code!)) {
-          warn(warning)
-        }
-      },
+      onwarn: onRollupWarning,
       ...config.rollupInputOptions,
       plugins: [
         ...(await createBaseRollupPlugins(root, resolver, config)),