diff --git a/docs/config/index.md b/docs/config/index.md
index f53d9d51ad3fd9..5fe4de59fd1a93 100644
--- a/docs/config/index.md
+++ b/docs/config/index.md
@@ -643,6 +643,17 @@ createServer()
 
   If disabled, all CSS in the entire project will be extracted into a single CSS file.
 
+### build.cssTarget
+
+- **Type:** `string | string[]`
+- **Default:** the same as [`build.target`](/config/#build-target)
+
+  This options allows users to set a different browser target for CSS minification from the one used for JavaScript transpilation.
+
+  It should only be used when you are targeting a non-mainstream browser.
+  One example is Android WeChat WebView, which supports most modern JavaScript features but not the [`#RGBA` hexadecimal color notation in CSS](https://developer.mozilla.org/en-US/docs/Web/CSS/color_value#rgb_colors).
+  In this case, you need to set `build.cssTarget` to `chrome61` to prevent vite from transform `rgba()` colors into `#RGBA` hexadecimal notations.
+
 ### build.sourcemap
 
 - **Type:** `boolean | 'inline' | 'hidden'`
diff --git a/packages/playground/css/__tests__/css.spec.ts b/packages/playground/css/__tests__/css.spec.ts
index ad5d9f344813e4..010f028a14ea82 100644
--- a/packages/playground/css/__tests__/css.spec.ts
+++ b/packages/playground/css/__tests__/css.spec.ts
@@ -338,3 +338,14 @@ test('inlined', async () => {
   // should not insert css
   expect(await getColor('.inlined')).toBe('black')
 })
+
+test('minify css', async () => {
+  if (!isBuild) {
+    return
+  }
+
+  // should keep the rgba() syntax
+  const cssFile = findAssetFile(/index\.\w+\.css$/)
+  expect(cssFile).toMatch('rgba(')
+  expect(cssFile).not.toMatch('#ffff00b3')
+})
diff --git a/packages/playground/css/main.js b/packages/playground/css/main.js
index cd2d6fda9ac0d5..24a278c8687940 100644
--- a/packages/playground/css/main.js
+++ b/packages/playground/css/main.js
@@ -1,3 +1,5 @@
+import './minify.css'
+
 import css from './imported.css'
 text('.imported-css', css)
 
diff --git a/packages/playground/css/minify.css b/packages/playground/css/minify.css
new file mode 100644
index 00000000000000..ada062407cdb38
--- /dev/null
+++ b/packages/playground/css/minify.css
@@ -0,0 +1,3 @@
+.test-minify {
+  color: rgba(255, 255, 0, 0.7);
+}
diff --git a/packages/playground/css/vite.config.js b/packages/playground/css/vite.config.js
index d49dcf4207834d..e4dc8d5a9f265f 100644
--- a/packages/playground/css/vite.config.js
+++ b/packages/playground/css/vite.config.js
@@ -3,6 +3,9 @@ const path = require('path')
  * @type {import('vite').UserConfig}
  */
 module.exports = {
+  build: {
+    cssTarget: 'chrome61'
+  },
   resolve: {
     alias: {
       '@': __dirname
diff --git a/packages/plugin-legacy/index.js b/packages/plugin-legacy/index.js
index a0a44499e34822..295fff9b95c4c3 100644
--- a/packages/plugin-legacy/index.js
+++ b/packages/plugin-legacy/index.js
@@ -86,6 +86,15 @@ function viteLegacyPlugin(options = {}) {
       if (!config.build) {
         config.build = {}
       }
+
+      if (!config.build.cssTarget) {
+        // Hint for esbuild that we are targeting legacy browsers when minifying CSS.
+        // Full CSS compat table available at https://github.com/evanw/esbuild/blob/78e04680228cf989bdd7d471e02bbc2c8d345dc9/internal/compat/css_table.go
+        // But note that only the `HexRGBA` feature affects the minify outcome.
+        // HSL & rebeccapurple values will be minified away regardless the target.
+        // So targeting `chrome61` suffices to fix the compatiblity issue.
+        config.build.cssTarget = 'chrome61'
+      }
     }
   }
 
@@ -125,7 +134,7 @@ function viteLegacyPlugin(options = {}) {
           bundle,
           facadeToModernPolyfillMap,
           config.build,
-          options.externalSystemJS,
+          options.externalSystemJS
         )
         return
       }
@@ -156,7 +165,7 @@ function viteLegacyPlugin(options = {}) {
           // force using terser for legacy polyfill minification, since esbuild
           // isn't legacy-safe
           config.build,
-          options.externalSystemJS,
+          options.externalSystemJS
         )
       }
     }
diff --git a/packages/vite/src/node/build.ts b/packages/vite/src/node/build.ts
index f11046c97fec25..0d376ac13d8ec8 100644
--- a/packages/vite/src/node/build.ts
+++ b/packages/vite/src/node/build.ts
@@ -102,6 +102,15 @@ export interface BuildOptions {
    * @default true
    */
   cssCodeSplit?: boolean
+  /**
+   * An optional separate target for CSS minification.
+   * As esbuild only supports configuring targets to mainstream
+   * browsers, users may need this option when they are targeting
+   * a niche browser that comes with most modern JavaScript features
+   * but has poor CSS support, e.g. Android WeChat WebView, which
+   * doesn't support the #RGBA syntax.
+   */
+  cssTarget?: TransformOptions['target'] | false
   /**
    * If `true`, a separate sourcemap file will be created. If 'inline', the
    * sourcemap will be appended to the resulting output file as data URI.
@@ -232,6 +241,7 @@ export function resolveBuildOptions(raw?: BuildOptions): ResolvedBuildOptions {
     assetsDir: 'assets',
     assetsInlineLimit: 4096,
     cssCodeSplit: !raw?.lib,
+    cssTarget: false,
     sourcemap: false,
     rollupOptions: {},
     commonjsOptions: {
@@ -275,6 +285,10 @@ export function resolveBuildOptions(raw?: BuildOptions): ResolvedBuildOptions {
     resolved.target = 'es2019'
   }
 
+  if (!resolved.cssTarget) {
+    resolved.cssTarget = resolved.target
+  }
+
   // normalize false string into actual false
   if ((resolved.minify as any) === 'false') {
     resolved.minify = false
diff --git a/packages/vite/src/node/plugins/css.ts b/packages/vite/src/node/plugins/css.ts
index dd7366874d984b..1a62bf7f028d13 100644
--- a/packages/vite/src/node/plugins/css.ts
+++ b/packages/vite/src/node/plugins/css.ts
@@ -906,7 +906,7 @@ async function minifyCSS(css: string, config: ResolvedConfig) {
   const { code, warnings } = await transform(css, {
     loader: 'css',
     minify: true,
-    target: config.build.target || undefined
+    target: config.build.cssTarget || undefined
   })
   if (warnings.length) {
     const msgs = await formatMessages(warnings, { kind: 'warning' })