diff --git a/docs/config/index.md b/docs/config/index.md
index bab7df7a144987..7b8db252d50450 100644
--- a/docs/config/index.md
+++ b/docs/config/index.md
@@ -1018,7 +1018,6 @@ export default defineConfig({
 
   - `external` is also omitted, use Vite's `optimizeDeps.exclude` option
   - `plugins` are merged with Vite's dep plugin
-  - `keepNames` takes precedence over the deprecated `optimizeDeps.keepNames`
 
 ## SSR Options
 
diff --git a/packages/plugin-react/src/index.ts b/packages/plugin-react/src/index.ts
index cefab59d94fe53..4ca3e0d371f6c9 100644
--- a/packages/plugin-react/src/index.ts
+++ b/packages/plugin-react/src/index.ts
@@ -38,15 +38,10 @@ export interface Options {
    * @default true
    */
   jsxPure?: boolean
-
   /**
    * Babel configuration applied in both dev and prod.
    */
   babel?: BabelOptions
-  /**
-   * @deprecated Use `babel.parserOpts.plugins` instead
-   */
-  parserPlugins?: ParserOptions['plugins']
 }
 
 export type BabelOptions = Omit<
@@ -104,7 +99,7 @@ export default function viteReact(opts: Options = {}): PluginOption[] {
   babelOptions.presets ||= []
   babelOptions.overrides ||= []
   babelOptions.parserOpts ||= {} as any
-  babelOptions.parserOpts.plugins ||= opts.parserPlugins || []
+  babelOptions.parserOpts.plugins ||= []
 
   // Support patterns like:
   // - import * as React from 'react';
diff --git a/packages/vite/src/client/client.ts b/packages/vite/src/client/client.ts
index 420d084ef9a981..06d46a000780f7 100644
--- a/packages/vite/src/client/client.ts
+++ b/packages/vite/src/client/client.ts
@@ -432,13 +432,6 @@ export function createHotContext(ownerPath: string): ViteHotContext {
       }
     },
 
-    acceptDeps() {
-      throw new Error(
-        `hot.acceptDeps() is deprecated. ` +
-          `Use hot.accept() with the same signature instead.`
-      )
-    },
-
     dispose(cb) {
       disposeMap.set(ownerPath, cb)
     },
diff --git a/packages/vite/src/node/__tests__/config.spec.ts b/packages/vite/src/node/__tests__/config.spec.ts
index dd427c19433475..19f8115a1d7102 100644
--- a/packages/vite/src/node/__tests__/config.spec.ts
+++ b/packages/vite/src/node/__tests__/config.spec.ts
@@ -159,52 +159,6 @@ describe('mergeConfig', () => {
   })
 })
 
-describe('resolveConfig', () => {
-  beforeAll(() => {
-    // silence deprecation warning
-    jest.spyOn(console, 'warn').mockImplementation(() => {})
-  })
-
-  afterAll(() => {
-    jest.clearAllMocks()
-  })
-
-  test('copies optimizeDeps.keepNames to esbuildOptions.keepNames', async () => {
-    const config: InlineConfig = {
-      optimizeDeps: {
-        keepNames: false
-      }
-    }
-
-    expect(await resolveConfig(config, 'serve')).toMatchObject({
-      optimizeDeps: {
-        esbuildOptions: {
-          keepNames: false
-        }
-      }
-    })
-  })
-
-  test('uses esbuildOptions.keepNames if set', async () => {
-    const config: InlineConfig = {
-      optimizeDeps: {
-        keepNames: true,
-        esbuildOptions: {
-          keepNames: false
-        }
-      }
-    }
-
-    expect(await resolveConfig(config, 'serve')).toMatchObject({
-      optimizeDeps: {
-        esbuildOptions: {
-          keepNames: false
-        }
-      }
-    })
-  })
-})
-
 describe('resolveEnvPrefix', () => {
   test(`use 'VITE_' as default value`, () => {
     const config: UserConfig = {}
diff --git a/packages/vite/src/node/build.ts b/packages/vite/src/node/build.ts
index ff03352a20d7a7..f584f007f2df5e 100644
--- a/packages/vite/src/node/build.ts
+++ b/packages/vite/src/node/build.ts
@@ -42,11 +42,6 @@ import { watchPackageDataPlugin } from './packages'
 import { ensureWatchPlugin } from './plugins/ensureWatch'
 
 export interface BuildOptions {
-  /**
-   * Base public path when served in production.
-   * @deprecated `base` is now a root-level config option.
-   */
-  base?: string
   /**
    * Compatibility transform target. The transform is performed with esbuild
    * and the lowest supported target is es2015/es6. Note this only handles
@@ -70,13 +65,6 @@ export interface BuildOptions {
    * @default true
    */
   polyfillModulePreload?: boolean
-  /**
-   * whether to inject dynamic import polyfill.
-   * Note: does not apply to library mode.
-   * @default false
-   * @deprecated use plugin-legacy for browsers that don't support dynamic import
-   */
-  polyfillDynamicImport?: boolean
   /**
    * Directory relative from `root` where build output will be placed. If the
    * directory exists, it will be removed before the build.
@@ -130,10 +118,6 @@ export interface BuildOptions {
    * https://terser.org/docs/api-reference#minify-options
    */
   terserOptions?: Terser.MinifyOptions
-  /**
-   * @deprecated Vite now uses esbuild for CSS minification.
-   */
-  cleanCssOptions?: any
   /**
    * Will be merged with internal rollup options.
    * https://rollupjs.org/guide/en/#big-list-of-options
@@ -198,12 +182,6 @@ export interface BuildOptions {
    * Can slightly improve build speed.
    */
   reportCompressedSize?: boolean
-  /**
-   * Set to false to disable brotli compressed size reporting for build.
-   * Can slightly improve build speed.
-   * @deprecated use `build.reportCompressedSize` instead.
-   */
-  brotliSize?: boolean
   /**
    * Adjust chunk size warning limit (in kbs).
    * @default 500
@@ -225,13 +203,7 @@ export interface LibraryOptions {
 
 export type LibraryFormats = 'es' | 'cjs' | 'umd' | 'iife'
 
-export type ResolvedBuildOptions = Required<
-  Omit<
-    BuildOptions,
-    // make deprecated options optional
-    'base' | 'cleanCssOptions' | 'polyfillDynamicImport' | 'brotliSize'
-  >
->
+export type ResolvedBuildOptions = Required<BuildOptions>
 
 export function resolveBuildOptions(raw?: BuildOptions): ResolvedBuildOptions {
   const resolved: ResolvedBuildOptions = {
@@ -253,7 +225,6 @@ export function resolveBuildOptions(raw?: BuildOptions): ResolvedBuildOptions {
     ssr: false,
     ssrManifest: false,
     reportCompressedSize: true,
-    // brotliSize: true,
     chunkSizeWarningLimit: 500,
     watch: null,
     ...raw,
@@ -451,15 +422,6 @@ async function doBuild(
 
   try {
     const buildOutputOptions = (output: OutputOptions = {}): OutputOptions => {
-      // @ts-ignore
-      if (output.output) {
-        config.logger.warn(
-          `You've set "rollupOptions.output.output" in your config. ` +
-            `This is deprecated and will override all Vite.js default output options. ` +
-            `Please use "rollupOptions.output" instead.`
-        )
-      }
-
       return {
         dir: outDir,
         format: ssr ? 'cjs' : 'es',
diff --git a/packages/vite/src/node/config.ts b/packages/vite/src/node/config.ts
index d242ac632c220e..b0085c9766c467 100644
--- a/packages/vite/src/node/config.ts
+++ b/packages/vite/src/node/config.ts
@@ -176,17 +176,6 @@ export interface UserConfig {
    * @default 'VITE_'
    */
   envPrefix?: string | string[]
-  /**
-   * Import aliases
-   * @deprecated use `resolve.alias` instead
-   */
-  alias?: AliasOptions
-  /**
-   * Force Vite to always resolve listed dependencies to the same copy (from
-   * project root).
-   * @deprecated use `resolve.dedupe` instead
-   */
-  dedupe?: string[]
   /**
    * Worker bundle options
    */
@@ -235,10 +224,7 @@ export interface InlineConfig extends UserConfig {
 }
 
 export type ResolvedConfig = Readonly<
-  Omit<
-    UserConfig,
-    'plugins' | 'alias' | 'dedupe' | 'assetsInclude' | 'optimizeDeps' | 'worker'
-  > & {
+  Omit<UserConfig, 'plugins' | 'assetsInclude' | 'optimizeDeps' | 'worker'> & {
     configFile: string | undefined
     configFileDependencies: string[]
     inlineConfig: InlineConfig
@@ -261,7 +247,7 @@ export type ResolvedConfig = Readonly<
     assetsInclude: (file: string) => boolean
     logger: Logger
     createResolver: (options?: Partial<InternalResolveOptions>) => ResolveFn
-    optimizeDeps: Omit<DepOptimizationOptions, 'keepNames'>
+    optimizeDeps: DepOptimizationOptions
     /** @internal */
     packageCache: PackageCache
     worker: ResolveWorkerOptions
@@ -370,12 +356,11 @@ export async function resolveConfig(
       // @ts-ignore because @rollup/plugin-alias' type doesn't allow function
       // replacement, but its implementation does work with function values.
       clientAlias,
-      config.resolve?.alias || config.alias || []
+      config.resolve?.alias || []
     )
   )
 
   const resolveOptions: ResolvedConfig['resolve'] = {
-    dedupe: config.dedupe,
     ...config.resolve,
     alias: resolvedAlias
   }
@@ -501,7 +486,6 @@ export async function resolveConfig(
     optimizeDeps: {
       ...optimizeDeps,
       esbuildOptions: {
-        keepNames: optimizeDeps.keepNames,
         preserveSymlinks: config.resolve?.preserveSymlinks,
         ...optimizeDeps.esbuildOptions
       }
@@ -540,117 +524,6 @@ export async function resolveConfig(
     })
   }
 
-  // TODO Deprecation warnings - remove when out of beta
-
-  const logDeprecationWarning = (
-    deprecatedOption: string,
-    hint: string,
-    error?: Error
-  ) => {
-    logger.warn(
-      colors.yellow(
-        colors.bold(
-          `(!) "${deprecatedOption}" option is deprecated. ${hint}${
-            error ? `\n${error.stack}` : ''
-          }`
-        )
-      )
-    )
-  }
-
-  if (config.build?.base) {
-    logDeprecationWarning(
-      'build.base',
-      '"base" is now a root-level config option.'
-    )
-    config.base = config.build.base
-  }
-  Object.defineProperty(resolvedBuildOptions, 'base', {
-    enumerable: false,
-    get() {
-      logDeprecationWarning(
-        'build.base',
-        '"base" is now a root-level config option.',
-        new Error()
-      )
-      return resolved.base
-    }
-  })
-
-  if (config.alias) {
-    logDeprecationWarning('alias', 'Use "resolve.alias" instead.')
-  }
-  Object.defineProperty(resolved, 'alias', {
-    enumerable: false,
-    get() {
-      logDeprecationWarning(
-        'alias',
-        'Use "resolve.alias" instead.',
-        new Error()
-      )
-      return resolved.resolve.alias
-    }
-  })
-
-  if (config.dedupe) {
-    logDeprecationWarning('dedupe', 'Use "resolve.dedupe" instead.')
-  }
-  Object.defineProperty(resolved, 'dedupe', {
-    enumerable: false,
-    get() {
-      logDeprecationWarning(
-        'dedupe',
-        'Use "resolve.dedupe" instead.',
-        new Error()
-      )
-      return resolved.resolve.dedupe
-    }
-  })
-
-  if (optimizeDeps.keepNames) {
-    logDeprecationWarning(
-      'optimizeDeps.keepNames',
-      'Use "optimizeDeps.esbuildOptions.keepNames" instead.'
-    )
-  }
-  Object.defineProperty(resolved.optimizeDeps, 'keepNames', {
-    enumerable: false,
-    get() {
-      logDeprecationWarning(
-        'optimizeDeps.keepNames',
-        'Use "optimizeDeps.esbuildOptions.keepNames" instead.',
-        new Error()
-      )
-      return resolved.optimizeDeps.esbuildOptions?.keepNames
-    }
-  })
-
-  if (config.build?.polyfillDynamicImport) {
-    logDeprecationWarning(
-      'build.polyfillDynamicImport',
-      '"polyfillDynamicImport" has been removed. Please use @vitejs/plugin-legacy if your target browsers do not support dynamic imports.'
-    )
-  }
-
-  Object.defineProperty(resolvedBuildOptions, 'polyfillDynamicImport', {
-    enumerable: false,
-    get() {
-      logDeprecationWarning(
-        'build.polyfillDynamicImport',
-        '"polyfillDynamicImport" has been removed. Please use @vitejs/plugin-legacy if your target browsers do not support dynamic imports.',
-        new Error()
-      )
-      return false
-    }
-  })
-
-  if (config.build?.cleanCssOptions) {
-    logDeprecationWarning(
-      'build.cleanCssOptions',
-      'Vite now uses esbuild for CSS minification.'
-    )
-  }
-
   if (config.build?.terserOptions && config.build.minify !== 'terser') {
     logger.warn(
       colors.yellow(
diff --git a/packages/vite/src/node/importGlob.ts b/packages/vite/src/node/importGlob.ts
index a759bee2b5fa59..ab425bb596c68a 100644
--- a/packages/vite/src/node/importGlob.ts
+++ b/packages/vite/src/node/importGlob.ts
@@ -17,7 +17,6 @@ import {
 } from './utils'
 import type { RollupError } from 'rollup'
 import type { Logger } from '.'
-import colors from 'picocolors'
 
 interface GlobParams {
   base: string
@@ -28,12 +27,6 @@ interface GlobParams {
 
 interface GlobOptions {
   as?: string
-  /**
-   * @deprecated
-   */
-  assert?: {
-    type: string
-  }
 }
 
 function formatGlobRelativePattern(base: string, pattern: string): GlobParams {
@@ -133,19 +126,9 @@ export async function transformImportGlob(
       ;[importee] = await normalizeUrl(file, pos)
     }
     imports.push(importee)
-    // TODO remove assert syntax for the Vite 3.0 release.
-    const isRawAssert = options?.assert?.type === 'raw'
+
     const isRawType = options?.as === 'raw'
-    if (isRawType || isRawAssert) {
-      if (isRawAssert) {
-        logger.warn(
-          colors.yellow(
-            colors.bold(
-              "(!) import.meta.glob('...', { assert: { type: 'raw' }}) is deprecated. Use import.meta.glob('...', { as: 'raw' }) instead."
-            )
-          )
-        )
-      }
+    if (isRawType) {
       entries += ` ${JSON.stringify(file)}: ${JSON.stringify(
         await fsp.readFile(path.join(base, files[i]), 'utf-8')
       )},`
diff --git a/packages/vite/src/node/index.ts b/packages/vite/src/node/index.ts
index 2e849d846527ca..c15359f45b69de 100644
--- a/packages/vite/src/node/index.ts
+++ b/packages/vite/src/node/index.ts
@@ -4,7 +4,7 @@ export { preview } from './preview'
 export { build } from './build'
 export { optimizeDeps } from './optimizer'
 export { send } from './server/send'
-export { createLogger, printHttpServerUrls } from './logger'
+export { createLogger } from './logger'
 export { formatPostcssSourceMap } from './plugins/css'
 export { transformWithEsbuild } from './plugins/esbuild'
 export { resolvePackageEntry } from './plugins/resolve'
diff --git a/packages/vite/src/node/logger.ts b/packages/vite/src/node/logger.ts
index 8ece2dd8746b7f..4f5784aeb527ff 100644
--- a/packages/vite/src/node/logger.ts
+++ b/packages/vite/src/node/logger.ts
@@ -144,16 +144,6 @@ export function createLogger(
   return logger
 }
 
-/**
- * @deprecated Use `server.printUrls()` instead
- */
-export function printHttpServerUrls(
-  server: Server,
-  config: ResolvedConfig
-): void {
-  printCommonServerUrls(server, config.server, config)
-}
-
 export function printCommonServerUrls(
   server: Server,
   options: CommonServerOptions,
diff --git a/packages/vite/src/node/optimizer/index.ts b/packages/vite/src/node/optimizer/index.ts
index 3828cb2fbce18b..5745749db3fb6a 100644
--- a/packages/vite/src/node/optimizer/index.ts
+++ b/packages/vite/src/node/optimizer/index.ts
@@ -70,7 +70,6 @@ export interface DepOptimizationOptions {
    *
    * - `external` is also omitted, use Vite's `optimizeDeps.exclude` option
    * - `plugins` are merged with Vite's dep plugin
-   * - `keepNames` takes precedence over the deprecated `optimizeDeps.keepNames`
    *
    * https://esbuild.github.io/api
    */
@@ -87,10 +86,6 @@ export interface DepOptimizationOptions {
     | 'outExtension'
     | 'metafile'
   >
-  /**
-   * @deprecated use `esbuildOptions.keepNames`
-   */
-  keepNames?: boolean
   /**
    * List of file extensions that can be optimized. A corresponding esbuild
    * plugin must exist to handle the specific extension.
diff --git a/packages/vite/src/node/plugins/reporter.ts b/packages/vite/src/node/plugins/reporter.ts
index 08650a86e2c38c..808e8040cba9f7 100644
--- a/packages/vite/src/node/plugins/reporter.ts
+++ b/packages/vite/src/node/plugins/reporter.ts
@@ -33,11 +33,7 @@ export function buildReporterPlugin(config: ResolvedConfig): Plugin {
   }
 
   async function getCompressedSize(code: string | Uint8Array): Promise<string> {
-    if (
-      config.build.ssr ||
-      !config.build.reportCompressedSize ||
-      config.build.brotliSize === false
-    ) {
+    if (config.build.ssr || !config.build.reportCompressedSize) {
       return ''
     }
     return ` / gzip: ${(
diff --git a/packages/vite/src/node/server/index.ts b/packages/vite/src/node/server/index.ts
index 99aefea6de292a..67214b4a6119b7 100644
--- a/packages/vite/src/node/server/index.ts
+++ b/packages/vite/src/node/server/index.ts
@@ -41,9 +41,6 @@ import { openBrowser } from './openBrowser'
 import launchEditorMiddleware from 'launch-editor-middleware'
 import type { TransformOptions, TransformResult } from './transformRequest'
 import { transformRequest } from './transformRequest'
-import type { ESBuildTransformResult } from '../plugins/esbuild'
-import { transformWithEsbuild } from '../plugins/esbuild'
-import type { TransformOptions as EsbuildTransformOptions } from 'esbuild'
 import { ssrLoadModule } from '../ssr/ssrModuleLoader'
 import { resolveSSRExternal } from '../ssr/ssrExternal'
 import {
@@ -156,10 +153,6 @@ export interface ViteDevServer {
    * https://github.com/senchalabs/connect#use-middleware
    */
   middlewares: Connect.Server
-  /**
-   * @deprecated use `server.middlewares` instead
-   */
-  app: Connect.Server
   /**
    * native Node http server instance
    * will be null in middleware mode
@@ -199,18 +192,6 @@ export interface ViteDevServer {
     html: string,
     originalUrl?: string
   ): Promise<string>
-  /**
-   * Util for transforming a file with esbuild.
-   * Can be useful for certain plugins.
-   *
-   * @deprecated import `transformWithEsbuild` from `vite` instead
-   */
-  transformWithEsbuild(
-    code: string,
-    filename: string,
-    options?: EsbuildTransformOptions,
-    inMap?: object
-  ): Promise<ESBuildTransformResult>
   /**
    * Transform module code into SSR format.
    * @experimental
@@ -342,19 +323,12 @@ export async function createServer(
   const server: ViteDevServer = {
     config,
     middlewares,
-    get app() {
-      config.logger.warn(
-        `ViteDevServer.app is deprecated. Use ViteDevServer.middlewares instead.`
-      )
-      return middlewares
-    },
     httpServer,
     watcher,
     pluginContainer: container,
     ws,
     moduleGraph,
     ssrTransform,
-    transformWithEsbuild,
     transformRequest(url, options) {
       return transformRequest(url, server, options)
     },
diff --git a/packages/vite/types/hot.d.ts b/packages/vite/types/hot.d.ts
index f06846ff59d530..daaf44e1efdc74 100644
--- a/packages/vite/types/hot.d.ts
+++ b/packages/vite/types/hot.d.ts
@@ -7,12 +7,6 @@ export interface ViteHotContext {
   accept(cb: (mod: any) => void): void
   accept(dep: string, cb: (mod: any) => void): void
   accept(deps: readonly string[], cb: (mods: any[]) => void): void
-
-  /**
-   * @deprecated
-   */
-  acceptDeps(): never
-
   dispose(cb: (data: any) => void): void
   decline(): void
   invalidate(): void
diff --git a/packages/vite/types/importMeta.d.ts b/packages/vite/types/importMeta.d.ts
index 900b975d37d6ad..06dcb52b9ad954 100644
--- a/packages/vite/types/importMeta.d.ts
+++ b/packages/vite/types/importMeta.d.ts
@@ -9,12 +9,6 @@
 // in vite/client.d.ts and in production src/node/importGlob.ts doesn't exist.
 interface GlobOptions {
   as?: string
-  /**
-   * @deprecated
-   */
-  assert?: {
-    type: string
-  }
 }
 
 interface ImportMeta {
diff --git a/packages/vite/types/terser.d.ts b/packages/vite/types/terser.d.ts
index 44c7398d508259..5c24660eb98781 100644
--- a/packages/vite/types/terser.d.ts
+++ b/packages/vite/types/terser.d.ts
@@ -185,8 +185,6 @@ export namespace Terser {
     module?: boolean
     nameCache?: object
     format?: FormatOptions
-    /** @deprecated use format instead */
-    output?: FormatOptions
     parse?: ParseOptions
     safari10?: boolean
     sourceMap?: boolean | SourceMapOptions