diff --git a/.buildkite/release-pipeline.yaml b/.buildkite/release-pipeline.yaml
new file mode 100644
index 0000000000000..1959f9752069f
--- /dev/null
+++ b/.buildkite/release-pipeline.yaml
@@ -0,0 +1,21 @@
+steps:
+  - block: "Build wheels"
+
+  - label: "Build wheel - Python {{matrix.python_version}}, CUDA {{matrix.cuda_version}}" 
+    agents:
+      queue: cpu_queue
+    commands:
+      - "DOCKER_BUILDKIT=1 docker build --build-arg max_jobs=16 --build-arg USE_SCCACHE=1 --build-arg CUDA_VERSION={{matrix.cuda_version}} --build-arg PYTHON_VERSION={{matrix.python_version}} --tag vllm-ci:build-image --target build --progress plain ."
+      - "mkdir artifacts"
+      - "docker run --rm -v $(pwd)/artifacts:/artifacts_host vllm-ci:build-image cp -r dist /artifacts_host"
+      - "aws s3 cp --recursive artifacts/dist s3://vllm-wheels/$BUILDKITE_COMMIT/"
+    matrix:
+      setup:
+        cuda_version:
+          - "11.8.0"
+          - "12.1.0"
+        python_version:
+          - "3.8"
+          - "3.9"
+          - "3.10"
+          - "3.11"
diff --git a/Dockerfile b/Dockerfile
index 72894e7cab9ba..5b3e682a80169 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -5,9 +5,26 @@
 # docs/source/dev/dockerfile/dockerfile.rst and
 # docs/source/assets/dev/dockerfile-stages-dependency.png
 
+ARG CUDA_VERSION=12.4.1
 #################### BASE BUILD IMAGE ####################
 # prepare basic build environment
-FROM nvidia/cuda:12.4.1-devel-ubuntu22.04 AS dev
+FROM nvidia/cuda:${CUDA_VERSION}-devel-ubuntu22.04 AS base
+
+ARG CUDA_VERSION=12.4.1
+ARG PYTHON_VERSION=3
+
+ENV DEBIAN_FRONTEND=noninteractive
+
+RUN echo 'tzdata tzdata/Areas select America' | debconf-set-selections \
+    && echo 'tzdata tzdata/Zones/America select Los_Angeles' | debconf-set-selections \
+    && apt-get update -y \
+    && apt-get install -y ccache software-properties-common \
+    && add-apt-repository ppa:deadsnakes/ppa \
+    && apt-get update -y \
+    && apt-get install -y python${PYTHON_VERSION} python${PYTHON_VERSION}-dev python${PYTHON_VERSION}-venv python3-pip \
+    && if [ "${PYTHON_VERSION}" != "3" ]; then update-alternatives --install /usr/bin/python3 python3 /usr/bin/python${PYTHON_VERSION} 1; fi \
+    && python3 --version \
+    && python3 -m pip --version
 
 RUN apt-get update -y \
     && apt-get install -y python3-pip git curl sudo
@@ -16,7 +33,7 @@ RUN apt-get update -y \
 # https://github.com/pytorch/pytorch/issues/107960 -- hopefully
 # this won't be needed for future versions of this docker image
 # or future versions of triton.
-RUN ldconfig /usr/local/cuda-12.4/compat/
+RUN ldconfig /usr/local/cuda-$(echo $CUDA_VERSION | cut -d. -f1,2)/compat/
 
 WORKDIR /workspace
 
@@ -24,14 +41,7 @@ WORKDIR /workspace
 COPY requirements-common.txt requirements-common.txt
 COPY requirements-cuda.txt requirements-cuda.txt
 RUN --mount=type=cache,target=/root/.cache/pip \
-    pip install -r requirements-cuda.txt
-
-# install development dependencies
-COPY requirements-lint.txt requirements-lint.txt
-COPY requirements-test.txt requirements-test.txt
-COPY requirements-dev.txt requirements-dev.txt
-RUN --mount=type=cache,target=/root/.cache/pip \
-    pip install -r requirements-dev.txt
+    python3 -m pip install -r requirements-cuda.txt
 
 # cuda arch list used by torch
 # can be useful for both `dev` and `test`
@@ -41,14 +51,16 @@ ARG torch_cuda_arch_list='7.0 7.5 8.0 8.6 8.9 9.0+PTX'
 ENV TORCH_CUDA_ARCH_LIST=${torch_cuda_arch_list}
 #################### BASE BUILD IMAGE ####################
 
-
 #################### WHEEL BUILD IMAGE ####################
-FROM dev AS build
+FROM base AS build
+
+ARG PYTHON_VERSION=3
 
 # install build dependencies
 COPY requirements-build.txt requirements-build.txt
+
 RUN --mount=type=cache,target=/root/.cache/pip \
-    pip install -r requirements-build.txt
+    python3 -m pip install -r requirements-build.txt
 
 # install compiler cache to speed up compilation leveraging local or remote caching
 RUN apt-get update -y && apt-get install -y ccache
@@ -101,9 +113,21 @@ RUN python3 check-wheel-size.py dist
 
 #################### EXTENSION Build IMAGE ####################
 
+#################### DEV IMAGE ####################
+FROM base as dev
+
+COPY requirements-lint.txt requirements-lint.txt
+COPY requirements-test.txt requirements-test.txt
+COPY requirements-dev.txt requirements-dev.txt
+RUN --mount=type=cache,target=/root/.cache/pip \
+    python3 -m pip install -r requirements-dev.txt
+
+#################### DEV IMAGE ####################
+
 #################### vLLM installation IMAGE ####################
 # image with vLLM installed
-FROM nvidia/cuda:12.4.1-base-ubuntu22.04 AS vllm-base
+FROM nvidia/cuda:${CUDA_VERSION}-base-ubuntu22.04 AS vllm-base
+ARG CUDA_VERSION=12.4.1
 WORKDIR /vllm-workspace
 
 RUN apt-get update -y \
@@ -113,12 +137,12 @@ RUN apt-get update -y \
 # https://github.com/pytorch/pytorch/issues/107960 -- hopefully
 # this won't be needed for future versions of this docker image
 # or future versions of triton.
-RUN ldconfig /usr/local/cuda-12.4/compat/
+RUN ldconfig /usr/local/cuda-$(echo $CUDA_VERSION | cut -d. -f1,2)/compat/
 
 # install vllm wheel first, so that torch etc will be installed
 RUN --mount=type=bind,from=build,src=/workspace/dist,target=/vllm-workspace/dist \
     --mount=type=cache,target=/root/.cache/pip \
-    pip install dist/*.whl --verbose
+    python3 -m pip install dist/*.whl --verbose
 #################### vLLM installation IMAGE ####################
 
 
@@ -131,7 +155,7 @@ ADD . /vllm-workspace/
 
 # install development dependencies (for testing)
 RUN --mount=type=cache,target=/root/.cache/pip \
-    pip install -r requirements-dev.txt
+    python3 -m pip install -r requirements-dev.txt
 
 # doc requires source code
 # we hide them inside `test_docs/` , so that this source code