diff --git a/packages/runtime-core/src/componentOptions.ts b/packages/runtime-core/src/componentOptions.ts
index e101a8c96a7..e00206baa00 100644
--- a/packages/runtime-core/src/componentOptions.ts
+++ b/packages/runtime-core/src/componentOptions.ts
@@ -424,6 +424,16 @@ interface LegacyOptions<
 
   // runtime compile only
   delimiters?: [string, string]
+
+  /**
+   * #3468
+   *
+   * type-only, used to assist Mixin's type inference,
+   * typescript will try to simplify the inferred `Mixin` type,
+   * with the `__differenciator`, typescript won't be able to combine different mixins,
+   * because the `__differenciator` will be different
+   */
+  __differentiator?: keyof D | keyof C | keyof M
 }
 
 export type OptionTypesKeys = 'P' | 'B' | 'D' | 'C' | 'M' | 'Defaults'
diff --git a/test-dts/defineComponent.test-d.tsx b/test-dts/defineComponent.test-d.tsx
index 8dbf7ca29ff..ff04a0d6f3f 100644
--- a/test-dts/defineComponent.test-d.tsx
+++ b/test-dts/defineComponent.test-d.tsx
@@ -775,6 +775,41 @@ describe('extends with mixins', () => {
   expectError(<MyComponent p2={'wrong type'} z={'z'} />)
   // @ts-expect-error
   expectError(<MyComponent mP1={3} />)
+
+  // #3468
+  const CompWithD = defineComponent({
+    data() {
+      return { foo: 1 }
+    }
+  })
+  const CompWithC = defineComponent({
+    computed: {
+      foo() {
+        return 1
+      }
+    }
+  })
+  const CompWithM = defineComponent({ methods: { foo() {} } })
+  const CompEmpty = defineComponent({})
+
+  defineComponent({
+    mixins: [CompWithD, CompEmpty],
+    mounted() {
+      expectType<number>(this.foo)
+    }
+  })
+  defineComponent({
+    mixins: [CompWithC, CompEmpty],
+    mounted() {
+      expectType<number>(this.foo)
+    }
+  })
+  defineComponent({
+    mixins: [CompWithM, CompEmpty],
+    mounted() {
+      expectType<() => void>(this.foo)
+    }
+  })
 })
 
 describe('compatibility w/ createApp', () => {