diff --git a/packages/compiler-core/src/parse.ts b/packages/compiler-core/src/parse.ts
index b72ad028b4b..f290f1b0261 100644
--- a/packages/compiler-core/src/parse.ts
+++ b/packages/compiler-core/src/parse.ts
@@ -507,9 +507,7 @@ const enum TagType {
   End
 }
 
-const isSpecialTemplateDirective = /*#__PURE__*/ makeMap(
-  `if,else,else-if,for,slot`
-)
+const isSpecialTemplateDirective = makeMap(`if,else,else-if,for,slot`)
 
 /**
  * Parse a tag (E.g. `<div id=a>`) with that type (start tag or end tag).
diff --git a/packages/compiler-core/src/transforms/transformExpression.ts b/packages/compiler-core/src/transforms/transformExpression.ts
index eab6b237f13..958bff19078 100644
--- a/packages/compiler-core/src/transforms/transformExpression.ts
+++ b/packages/compiler-core/src/transforms/transformExpression.ts
@@ -43,7 +43,7 @@ import { parse } from '@babel/parser'
 import { IS_REF, UNREF } from '../runtimeHelpers'
 import { BindingTypes } from '../options'
 
-const isLiteralWhitelisted = /*#__PURE__*/ makeMap('true,false,null,this')
+const isLiteralWhitelisted = makeMap('true,false,null,this')
 
 // a heuristic safeguard to bail constant expressions on presence of
 // likely function invocation and member access
diff --git a/packages/compiler-dom/src/parserOptions.ts b/packages/compiler-dom/src/parserOptions.ts
index 4d06a776b7a..e8c6f4281b2 100644
--- a/packages/compiler-dom/src/parserOptions.ts
+++ b/packages/compiler-dom/src/parserOptions.ts
@@ -10,10 +10,7 @@ import { TRANSITION, TRANSITION_GROUP } from './runtimeHelpers'
 import { decodeHtml } from './decodeHtml'
 import { decodeHtmlBrowser } from './decodeHtmlBrowser'
 
-const isRawTextContainer = /*#__PURE__*/ makeMap(
-  'style,iframe,script,noscript',
-  true
-)
+const isRawTextContainer = makeMap('style,iframe,script,noscript', true)
 
 export const enum DOMNamespaces {
   HTML = 0 /* Namespaces.HTML */,
diff --git a/packages/compiler-dom/src/transforms/stringifyStatic.ts b/packages/compiler-dom/src/transforms/stringifyStatic.ts
index 0b47cb435b0..b0258bf588d 100644
--- a/packages/compiler-dom/src/transforms/stringifyStatic.ts
+++ b/packages/compiler-dom/src/transforms/stringifyStatic.ts
@@ -167,7 +167,7 @@ const replaceHoist = (
   context.hoists[context.hoists.indexOf(hoistToReplace)] = replacement
 }
 
-const isNonStringifiable = /*#__PURE__*/ makeMap(
+const isNonStringifiable = makeMap(
   `caption,thead,tr,th,tbody,td,tfoot,colgroup,col`
 )
 
diff --git a/packages/compiler-dom/src/transforms/vOn.ts b/packages/compiler-dom/src/transforms/vOn.ts
index 660003b4839..f5aaa432f8b 100644
--- a/packages/compiler-dom/src/transforms/vOn.ts
+++ b/packages/compiler-dom/src/transforms/vOn.ts
@@ -17,8 +17,8 @@ import {
 import { V_ON_WITH_MODIFIERS, V_ON_WITH_KEYS } from '../runtimeHelpers'
 import { makeMap, capitalize } from '@vue/shared'
 
-const isEventOptionModifier = /*#__PURE__*/ makeMap(`passive,once,capture`)
-const isNonKeyModifier = /*#__PURE__*/ makeMap(
+const isEventOptionModifier = makeMap(`passive,once,capture`)
+const isNonKeyModifier = makeMap(
   // event propagation management
   `stop,prevent,self,` +
     // system modifiers + exact
@@ -27,11 +27,8 @@ const isNonKeyModifier = /*#__PURE__*/ makeMap(
     `middle`
 )
 // left & right could be mouse or key modifiers based on event type
-const maybeKeyModifier = /*#__PURE__*/ makeMap('left,right')
-const isKeyboardEvent = /*#__PURE__*/ makeMap(
-  `onkeyup,onkeydown,onkeypress`,
-  true
-)
+const maybeKeyModifier = makeMap('left,right')
+const isKeyboardEvent = makeMap(`onkeyup,onkeydown,onkeypress`, true)
 
 const resolveModifiers = (
   key: ExpressionNode,
diff --git a/packages/reactivity/src/baseHandlers.ts b/packages/reactivity/src/baseHandlers.ts
index 259b44a1edc..92caad1bd2b 100644
--- a/packages/reactivity/src/baseHandlers.ts
+++ b/packages/reactivity/src/baseHandlers.ts
@@ -31,7 +31,7 @@ import {
 import { isRef } from './ref'
 import { warn } from './warning'
 
-const isNonTrackableKeys = /*#__PURE__*/ makeMap(`__proto__,__v_isRef,__isVue`)
+const isNonTrackableKeys = makeMap(`__proto__,__v_isRef,__isVue`)
 
 const builtInSymbols = new Set(
   /*#__PURE__*/
diff --git a/packages/reactivity/src/collectionHandlers.ts b/packages/reactivity/src/collectionHandlers.ts
index 1d07af3be8c..633aef322b6 100644
--- a/packages/reactivity/src/collectionHandlers.ts
+++ b/packages/reactivity/src/collectionHandlers.ts
@@ -331,6 +331,7 @@ const [
   shallowReadonlyInstrumentations
 ] = /* #__PURE__*/ createInstrumentations()
 
+/*! #__NO_SIDE_EFFECTS__ */
 function createInstrumentationGetter(isReadonly: boolean, shallow: boolean) {
   const instrumentations = shallow
     ? isReadonly
@@ -364,20 +365,20 @@ function createInstrumentationGetter(isReadonly: boolean, shallow: boolean) {
 }
 
 export const mutableCollectionHandlers: ProxyHandler<CollectionTypes> = {
-  get: /*#__PURE__*/ createInstrumentationGetter(false, false)
+  get: createInstrumentationGetter(false, false)
 }
 
 export const shallowCollectionHandlers: ProxyHandler<CollectionTypes> = {
-  get: /*#__PURE__*/ createInstrumentationGetter(false, true)
+  get: createInstrumentationGetter(false, true)
 }
 
 export const readonlyCollectionHandlers: ProxyHandler<CollectionTypes> = {
-  get: /*#__PURE__*/ createInstrumentationGetter(true, false)
+  get: createInstrumentationGetter(true, false)
 }
 
 export const shallowReadonlyCollectionHandlers: ProxyHandler<CollectionTypes> =
   {
-    get: /*#__PURE__*/ createInstrumentationGetter(true, true)
+    get: createInstrumentationGetter(true, true)
   }
 
 function checkIdentityKeys(
diff --git a/packages/runtime-core/src/compat/renderFn.ts b/packages/runtime-core/src/compat/renderFn.ts
index 4cf2fc226cf..d90c882b66f 100644
--- a/packages/runtime-core/src/compat/renderFn.ts
+++ b/packages/runtime-core/src/compat/renderFn.ts
@@ -170,7 +170,7 @@ export function compatH(
   }
 }
 
-const skipLegacyRootLevelProps = /*#__PURE__*/ makeMap(
+const skipLegacyRootLevelProps = makeMap(
   'staticStyle,staticClass,directives,model,hook'
 )
 
diff --git a/packages/runtime-core/src/component.ts b/packages/runtime-core/src/component.ts
index 57a53a39b76..6e45dde62b0 100644
--- a/packages/runtime-core/src/component.ts
+++ b/packages/runtime-core/src/component.ts
@@ -638,7 +638,7 @@ export const unsetCurrentInstance = () => {
   internalSetCurrentInstance(null)
 }
 
-const isBuiltInTag = /*#__PURE__*/ makeMap('slot,component')
+const isBuiltInTag = makeMap('slot,component')
 
 export function validateComponentName(name: string, config: AppConfig) {
   const appIsNativeTag = config.isNativeTag || NO
diff --git a/packages/runtime-core/src/componentProps.ts b/packages/runtime-core/src/componentProps.ts
index 4d402789555..004b341e5e6 100644
--- a/packages/runtime-core/src/componentProps.ts
+++ b/packages/runtime-core/src/componentProps.ts
@@ -680,9 +680,7 @@ function validateProp(
   }
 }
 
-const isSimpleType = /*#__PURE__*/ makeMap(
-  'String,Number,Boolean,Function,Symbol,BigInt'
-)
+const isSimpleType = makeMap('String,Number,Boolean,Function,Symbol,BigInt')
 
 type AssertionResult = {
   valid: boolean
diff --git a/packages/runtime-core/src/componentPublicInstance.ts b/packages/runtime-core/src/componentPublicInstance.ts
index dc575aafff9..e571e399d42 100644
--- a/packages/runtime-core/src/componentPublicInstance.ts
+++ b/packages/runtime-core/src/componentPublicInstance.ts
@@ -257,7 +257,7 @@ const getPublicInstance = (
 export const publicPropertiesMap: PublicPropertiesMap =
   // Move PURE marker to new line to workaround compiler discarding it
   // due to type annotation
-  /*#__PURE__*/ extend(Object.create(null), {
+  extend(Object.create(null), {
     $: i => i,
     $el: i => i.vnode.el,
     $data: i => i.data,
@@ -499,7 +499,7 @@ if (__DEV__ && !__TEST__) {
   }
 }
 
-export const RuntimeCompiledPublicInstanceProxyHandlers = /*#__PURE__*/ extend(
+export const RuntimeCompiledPublicInstanceProxyHandlers = extend(
   {},
   PublicInstanceProxyHandlers,
   {
diff --git a/packages/runtime-core/src/devtools.ts b/packages/runtime-core/src/devtools.ts
index bf67093f5c3..f1ebbe3c814 100644
--- a/packages/runtime-core/src/devtools.ts
+++ b/packages/runtime-core/src/devtools.ts
@@ -99,14 +99,15 @@ export function devtoolsUnmountApp(app: App) {
   emit(DevtoolsHooks.APP_UNMOUNT, app)
 }
 
-export const devtoolsComponentAdded = /*#__PURE__*/ createDevtoolsComponentHook(
+export const devtoolsComponentAdded = createDevtoolsComponentHook(
   DevtoolsHooks.COMPONENT_ADDED
 )
 
-export const devtoolsComponentUpdated =
-  /*#__PURE__*/ createDevtoolsComponentHook(DevtoolsHooks.COMPONENT_UPDATED)
+export const devtoolsComponentUpdated = createDevtoolsComponentHook(
+  DevtoolsHooks.COMPONENT_UPDATED
+)
 
-const _devtoolsComponentRemoved = /*#__PURE__*/ createDevtoolsComponentHook(
+const _devtoolsComponentRemoved = createDevtoolsComponentHook(
   DevtoolsHooks.COMPONENT_REMOVED
 )
 
@@ -123,6 +124,7 @@ export const devtoolsComponentRemoved = (
   }
 }
 
+/*! #__NO_SIDE_EFFECTS__ */
 function createDevtoolsComponentHook(hook: DevtoolsHooks) {
   return (component: ComponentInternalInstance) => {
     emit(
@@ -135,14 +137,15 @@ function createDevtoolsComponentHook(hook: DevtoolsHooks) {
   }
 }
 
-export const devtoolsPerfStart = /*#__PURE__*/ createDevtoolsPerformanceHook(
+export const devtoolsPerfStart = createDevtoolsPerformanceHook(
   DevtoolsHooks.PERFORMANCE_START
 )
 
-export const devtoolsPerfEnd = /*#__PURE__*/ createDevtoolsPerformanceHook(
+export const devtoolsPerfEnd = createDevtoolsPerformanceHook(
   DevtoolsHooks.PERFORMANCE_END
 )
 
+/*! #__NO_SIDE_EFFECTS__ */
 function createDevtoolsPerformanceHook(hook: DevtoolsHooks) {
   return (component: ComponentInternalInstance, type: string, time: number) => {
     emit(hook, component.appContext.app, component.uid, component, type, time)
diff --git a/packages/runtime-dom/src/components/Transition.ts b/packages/runtime-dom/src/components/Transition.ts
index b0675213298..48379adcfa2 100644
--- a/packages/runtime-dom/src/components/Transition.ts
+++ b/packages/runtime-dom/src/components/Transition.ts
@@ -74,12 +74,11 @@ const DOMTransitionPropsValidators = {
   leaveToClass: String
 }
 
-export const TransitionPropsValidators = (Transition.props =
-  /*#__PURE__*/ extend(
-    {},
-    BaseTransitionPropsValidators as any,
-    DOMTransitionPropsValidators
-  ))
+export const TransitionPropsValidators = (Transition.props = extend(
+  {},
+  BaseTransitionPropsValidators as any,
+  DOMTransitionPropsValidators
+))
 
 /**
  * #3227 Incoming hooks may be merged into arrays when wrapping Transition
diff --git a/packages/runtime-dom/src/components/TransitionGroup.ts b/packages/runtime-dom/src/components/TransitionGroup.ts
index fc5d260b91e..d27a3df55a3 100644
--- a/packages/runtime-dom/src/components/TransitionGroup.ts
+++ b/packages/runtime-dom/src/components/TransitionGroup.ts
@@ -40,7 +40,7 @@ export type TransitionGroupProps = Omit<TransitionProps, 'mode'> & {
 const TransitionGroupImpl: ComponentOptions = {
   name: 'TransitionGroup',
 
-  props: /*#__PURE__*/ extend({}, TransitionPropsValidators, {
+  props: extend({}, TransitionPropsValidators, {
     tag: String,
     moveClass: String
   }),
diff --git a/packages/runtime-dom/src/index.ts b/packages/runtime-dom/src/index.ts
index ad818a34bb7..a97cac22a6a 100644
--- a/packages/runtime-dom/src/index.ts
+++ b/packages/runtime-dom/src/index.ts
@@ -30,7 +30,7 @@ declare module '@vue/reactivity' {
   }
 }
 
-const rendererOptions = /*#__PURE__*/ extend({ patchProp }, nodeOps)
+const rendererOptions = extend({ patchProp }, nodeOps)
 
 // lazy create the renderer - this makes core renderer logic tree-shakable
 // in case the user only imports reactivity utilities from Vue.
diff --git a/packages/runtime-dom/src/modules/attrs.ts b/packages/runtime-dom/src/modules/attrs.ts
index 41648ed50dc..147e1c17916 100644
--- a/packages/runtime-dom/src/modules/attrs.ts
+++ b/packages/runtime-dom/src/modules/attrs.ts
@@ -43,7 +43,7 @@ export function patchAttr(
 
 // 2.x compat
 const isEnumeratedAttr = __COMPAT__
-  ? /*#__PURE__*/ makeMap('contenteditable,draggable,spellcheck')
+  ? makeMap('contenteditable,draggable,spellcheck')
   : NOOP
 
 export function compatCoerceAttr(
diff --git a/packages/shared/src/domAttrConfig.ts b/packages/shared/src/domAttrConfig.ts
index 5f7f851b0df..f1c7e39e81a 100644
--- a/packages/shared/src/domAttrConfig.ts
+++ b/packages/shared/src/domAttrConfig.ts
@@ -12,12 +12,12 @@ import { makeMap } from './makeMap'
  * - readonly -> readOnly
  */
 const specialBooleanAttrs = `itemscope,allowfullscreen,formnovalidate,ismap,nomodule,novalidate,readonly`
-export const isSpecialBooleanAttr = /*#__PURE__*/ makeMap(specialBooleanAttrs)
+export const isSpecialBooleanAttr = makeMap(specialBooleanAttrs)
 
 /**
  * The full list is needed during SSR to produce the correct initial markup.
  */
-export const isBooleanAttr = /*#__PURE__*/ makeMap(
+export const isBooleanAttr = makeMap(
   specialBooleanAttrs +
     `,async,autofocus,autoplay,controls,default,defer,disabled,hidden,` +
     `inert,loop,open,required,reversed,scoped,seamless,` +
@@ -59,7 +59,7 @@ export const propsToAttrMap: Record<string, string | undefined> = {
  * Don't also forget to allow `data-*` and `aria-*`!
  * Generated from https://developer.mozilla.org/en-US/docs/Web/HTML/Attributes
  */
-export const isKnownHtmlAttr = /*#__PURE__*/ makeMap(
+export const isKnownHtmlAttr = makeMap(
   `accept,accept-charset,accesskey,action,align,allow,alt,async,` +
     `autocapitalize,autocomplete,autofocus,autoplay,background,bgcolor,` +
     `border,buffered,capture,challenge,charset,checked,cite,class,code,` +
@@ -80,7 +80,7 @@ export const isKnownHtmlAttr = /*#__PURE__*/ makeMap(
 /**
  * Generated from https://developer.mozilla.org/en-US/docs/Web/SVG/Attribute
  */
-export const isKnownSvgAttr = /*#__PURE__*/ makeMap(
+export const isKnownSvgAttr = makeMap(
   `xmlns,accent-height,accumulate,additive,alignment-baseline,alphabetic,amplitude,` +
     `arabic-form,ascent,attributeName,attributeType,azimuth,baseFrequency,` +
     `baseline-shift,baseProfile,bbox,begin,bias,by,calcMode,cap-height,class,` +
diff --git a/packages/shared/src/domTagConfig.ts b/packages/shared/src/domTagConfig.ts
index 535aa6be718..ef48ddc2c9d 100644
--- a/packages/shared/src/domTagConfig.ts
+++ b/packages/shared/src/domTagConfig.ts
@@ -34,14 +34,14 @@ const VOID_TAGS =
  * Compiler only.
  * Do NOT use in runtime code paths unless behind `__DEV__` flag.
  */
-export const isHTMLTag = /*#__PURE__*/ makeMap(HTML_TAGS)
+export const isHTMLTag = makeMap(HTML_TAGS)
 /**
  * Compiler only.
  * Do NOT use in runtime code paths unless behind `__DEV__` flag.
  */
-export const isSVGTag = /*#__PURE__*/ makeMap(SVG_TAGS)
+export const isSVGTag = makeMap(SVG_TAGS)
 /**
  * Compiler only.
  * Do NOT use in runtime code paths unless behind `__DEV__` flag.
  */
-export const isVoidTag = /*#__PURE__*/ makeMap(VOID_TAGS)
+export const isVoidTag = makeMap(VOID_TAGS)
diff --git a/packages/shared/src/general.ts b/packages/shared/src/general.ts
index 0117e67000d..5833be98e27 100644
--- a/packages/shared/src/general.ts
+++ b/packages/shared/src/general.ts
@@ -17,6 +17,7 @@ export const isOn = (key: string) => onRE.test(key)
 
 export const isModelListener = (key: string) => key.startsWith('onUpdate:')
 
+/*! #__NO_SIDE_EFFECTS__ */
 export const extend = Object.assign
 
 export const remove = <T>(arr: T[], el: T) => {
@@ -75,7 +76,7 @@ export const isIntegerKey = (key: unknown) =>
   key[0] !== '-' &&
   '' + parseInt(key, 10) === key
 
-export const isReservedProp = /*#__PURE__*/ makeMap(
+export const isReservedProp = makeMap(
   // the leading comma is intentional so empty string "" is also included
   ',key,ref,ref_for,ref_key,' +
     'onVnodeBeforeMount,onVnodeMounted,' +
@@ -83,7 +84,7 @@ export const isReservedProp = /*#__PURE__*/ makeMap(
     'onVnodeBeforeUnmount,onVnodeUnmounted'
 )
 
-export const isBuiltInDirective = /*#__PURE__*/ makeMap(
+export const isBuiltInDirective = makeMap(
   'bind,cloak,else-if,else,for,html,if,model,on,once,pre,show,slot,text,memo'
 )
 
diff --git a/packages/shared/src/globalsAllowList.ts b/packages/shared/src/globalsAllowList.ts
index 4af518c22f1..08ae4f6c38a 100644
--- a/packages/shared/src/globalsAllowList.ts
+++ b/packages/shared/src/globalsAllowList.ts
@@ -5,7 +5,7 @@ const GLOBALS_ALLOWED =
   'decodeURIComponent,encodeURI,encodeURIComponent,Math,Number,Date,Array,' +
   'Object,Boolean,String,RegExp,Map,Set,JSON,Intl,BigInt,console'
 
-export const isGloballyAllowed = /*#__PURE__*/ makeMap(GLOBALS_ALLOWED)
+export const isGloballyAllowed = makeMap(GLOBALS_ALLOWED)
 
 /** @deprecated use `isGloballyAllowed` instead */
 export const isGloballyWhitelisted = isGloballyAllowed
diff --git a/packages/shared/src/makeMap.ts b/packages/shared/src/makeMap.ts
index b598704c673..e49b1bf3d36 100644
--- a/packages/shared/src/makeMap.ts
+++ b/packages/shared/src/makeMap.ts
@@ -5,6 +5,8 @@
  * \/\*#\_\_PURE\_\_\*\/
  * So that rollup can tree-shake them if necessary.
  */
+
+/*! #__NO_SIDE_EFFECTS__ */
 export function makeMap(
   str: string,
   expectsLowerCase?: boolean