diff --git a/src/animation.js b/src/animation.js
index f1d21d8..e9f6482 100644
--- a/src/animation.js
+++ b/src/animation.js
@@ -94,7 +94,7 @@
         this._paused = true;
       }
       this._tickCurrentTime(newTime, true);
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(this);
     },
     get startTime() {
       return this._startTime;
@@ -107,7 +107,7 @@
         return;
       this._startTime = newTime;
       this._tickCurrentTime((this._timeline.currentTime - this._startTime) * this.playbackRate);
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(this);
     },
     get playbackRate() {
       return this._playbackRate;
@@ -123,7 +123,7 @@
         this._finishedFlag = false;
         this._idle = false;
         this._ensureAlive();
-        scope.invalidateEffects();
+        scope.applyDirtiedAnimation(this);
       }
       if (oldCurrentTime != null) {
         this.currentTime = oldCurrentTime;
@@ -165,7 +165,7 @@
       this._finishedFlag = false;
       this._idle = false;
       this._ensureAlive();
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(this);
     },
     pause: function() {
       if (!this._isFinished && !this._paused && !this._idle) {
@@ -183,7 +183,7 @@
       this.currentTime = this._playbackRate > 0 ? this._totalDuration : 0;
       this._startTime = this._totalDuration - this.currentTime;
       this._currentTimePending = false;
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(this);
     },
     cancel: function() {
       if (!this._inEffect)
@@ -191,13 +191,14 @@
       this._inEffect = false;
       this._idle = true;
       this._paused = false;
+      this._isFinished = true;
       this._finishedFlag = true;
       this._currentTime = 0;
       this._startTime = null;
       this._effect._update(null);
       // effects are invalid after cancellation as the animation state
       // needs to un-apply.
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(this);
     },
     reverse: function() {
       this.playbackRate *= -1;
@@ -249,6 +250,26 @@
     get _needsTick() {
       return (this.playState in {'pending': 1, 'running': 1}) || !this._finishedFlag;
     },
+    _targetAnimations: function() {
+      var target = this._effect._target;
+      if (!target._activeAnimations) {
+        target._activeAnimations = [];
+      }
+      return target._activeAnimations;
+    },
+    _markTarget: function() {
+      var animations = this._targetAnimations();
+      if (animations.indexOf(this) === -1) {
+        animations.push(this);
+      }
+    },
+    _unmarkTarget: function() {
+      var animations = this._targetAnimations();
+      var index = animations.indexOf(this);
+      if (index !== -1) {
+        animations.splice(index, 1);
+      }
+    },
   };
 
   if (WEB_ANIMATIONS_TESTING) {
diff --git a/src/keyframe-effect.js b/src/keyframe-effect.js
index c79f05d..f6813d8 100644
--- a/src/keyframe-effect.js
+++ b/src/keyframe-effect.js
@@ -43,6 +43,7 @@
     keyframeEffect._hasSameTarget = function(otherTarget) {
       return target === otherTarget;
     };
+    keyframeEffect._target = target;
     keyframeEffect._totalDuration = effectTime._totalDuration;
     keyframeEffect._id = id;
     return keyframeEffect;
diff --git a/src/tick.js b/src/tick.js
index 3112f6b..08b0a14 100644
--- a/src/tick.js
+++ b/src/tick.js
@@ -39,7 +39,8 @@
     rafCallbacks = [];
     if (t < timeline.currentTime)
       t = timeline.currentTime;
-    tick(t, true);
+    timeline._animations.sort(compareAnimations);
+    timeline._animations = tick(t, true, timeline._animations)[0];
     processing.forEach(function(entry) { entry[1](t); });
     applyPendingEffects();
     _now = undefined;
@@ -63,7 +64,7 @@
       animation._timeline = this;
       this._animations.push(animation);
       scope.restart();
-      scope.invalidateEffects();
+      scope.applyDirtiedAnimation(animation);
       return animation;
     }
   };
@@ -92,8 +93,24 @@
     return hasRestartedThisFrame;
   };
 
-  scope.invalidateEffects = function() {
-    tick(scope.timeline.currentTime, false);
+  // RAF is supposed to be the last script to occur before frame rendering but not
+  // all browsers behave like this. This function is for synchonously updating an
+  // animation's effects whenever its state is mutated by script to work around
+  // incorrect script execution ordering by the browser.
+  scope.applyDirtiedAnimation = function(animation) {
+    if (inTick) {
+      return;
+    }
+    animation._markTarget();
+    var animations = animation._targetAnimations();
+    animations.sort(compareAnimations);
+    var inactiveAnimations = tick(scope.timeline.currentTime, false, animations.slice())[1];
+    inactiveAnimations.forEach(function(animation) {
+      var index = timeline._animations.indexOf(animation);
+      if (index !== -1) {
+        timeline._animations.splice(index, 1);
+      }
+    });
     applyPendingEffects();
   };
 
@@ -105,41 +122,51 @@
 
   var t60hz = 1000 / 60;
 
-  function tick(t, isAnimationFrame) {
+  var inTick = false;
+  function tick(t, isAnimationFrame, updatingAnimations) {
+    inTick = true;
     hasRestartedThisFrame = false;
     var timeline = scope.timeline;
+
     timeline.currentTime = t;
-    timeline._animations.sort(compareAnimations);
     ticking = false;
-    var updatingAnimations = timeline._animations;
-    timeline._animations = [];
 
     var newPendingClears = [];
     var newPendingEffects = [];
-    updatingAnimations = updatingAnimations.filter(function(animation) {
+    var activeAnimations = [];
+    var inactiveAnimations = [];
+    updatingAnimations.forEach(function(animation) {
       animation._tick(t, isAnimationFrame);
 
-      if (!animation._inEffect)
+      if (!animation._inEffect) {
         newPendingClears.push(animation._effect);
-      else
+        animation._unmarkTarget();
+      } else {
         newPendingEffects.push(animation._effect);
+        animation._markTarget();
+      }
 
       if (animation._needsTick)
         ticking = true;
 
       var alive = animation._inEffect || animation._needsTick;
       animation._inTimeline = alive;
-      return alive;
+      if (alive) {
+        activeAnimations.push(animation);
+      } else {
+        inactiveAnimations.push(animation);
+      }
     });
 
     // FIXME: Should remove dupliactes from pendingEffects.
     pendingEffects.push.apply(pendingEffects, newPendingClears);
     pendingEffects.push.apply(pendingEffects, newPendingEffects);
 
-    timeline._animations.push.apply(timeline._animations, updatingAnimations);
-
     if (ticking)
       requestAnimationFrame(function() {});
+
+    inTick = false;
+    return [activeAnimations, inactiveAnimations];
   };
 
   if (WEB_ANIMATIONS_TESTING) {