diff --git a/.changeset/warm-gifts-jam.md b/.changeset/warm-gifts-jam.md
new file mode 100644
index 000000000000..8c2ccd85c5a8
--- /dev/null
+++ b/.changeset/warm-gifts-jam.md
@@ -0,0 +1,5 @@
+---
+'astro': patch
+---
+
+Fix some global state related to `astro:assets` not getting cleaned out properly in SSR with no pre-rendered pages
diff --git a/packages/astro/src/core/build/generate.ts b/packages/astro/src/core/build/generate.ts
index 1f8d170a04b7..708295296399 100644
--- a/packages/astro/src/core/build/generate.ts
+++ b/packages/astro/src/core/build/generate.ts
@@ -130,7 +130,12 @@ export async function generatePages(opts: StaticBuildOptions, internals: BuildIn
 		? opts.settings.config.build.server
 		: getOutDirWithinCwd(opts.settings.config.outDir);
 
-	if (ssr && !hasPrerenderedPages(internals)) return;
+	// HACK! `astro:assets` relies on a global to know if its running in dev, prod, ssr, ssg, full moon
+	// If we don't delete it here, it's technically not impossible (albeit improbable) for it to leak
+	if (ssr && !hasPrerenderedPages(internals)) {
+		delete globalThis?.astroAsset?.addStaticImage;
+		return;
+	}
 
 	const verb = ssr ? 'prerendering' : 'generating';
 	info(opts.logging, null, `\n${bgGreen(black(` ${verb} static routes `))}`);
@@ -186,7 +191,7 @@ export async function generatePages(opts: StaticBuildOptions, internals: BuildIn
 			await generateImage(opts, imageData[1].options, imageData[1].path);
 		}
 
-		delete globalThis.astroAsset.addStaticImage;
+		delete globalThis?.astroAsset?.addStaticImage;
 	}
 
 	await runHookBuildGenerated({
diff --git a/packages/astro/test/astro-assets-prefix.test.js b/packages/astro/test/astro-assets-prefix.test.js
index 58eb11e39b6a..40562afd4788 100644
--- a/packages/astro/test/astro-assets-prefix.test.js
+++ b/packages/astro/test/astro-assets-prefix.test.js
@@ -132,14 +132,14 @@ describe('Assets Prefix - Server', () => {
 		expect(island.attr('renderer-url')).to.match(assetsPrefixRegex);
 	});
 
-	it('markdown image src start with assetsPrefix', async () => {
+	it('markdown optimized image src does not start with assetsPrefix in SSR', async () => {
 		const request = new Request('http://example.com/custom-base/markdown/');
 		const response = await app.render(request);
 		expect(response.status).to.equal(200);
 		const html = await response.text();
 		const $ = cheerio.load(html);
 		const imgAsset = $('img');
-		expect(imgAsset.attr('src')).to.match(assetsPrefixRegex);
+		expect(imgAsset.attr('src')).to.not.match(assetsPrefixRegex);
 	});
 });
 
diff --git a/packages/integrations/node/test/fixtures/image/package.json b/packages/integrations/node/test/fixtures/image/package.json
new file mode 100644
index 000000000000..94066576deab
--- /dev/null
+++ b/packages/integrations/node/test/fixtures/image/package.json
@@ -0,0 +1,13 @@
+{
+  "name": "@test/nodejs-image",
+  "version": "0.0.0",
+  "private": true,
+  "dependencies": {
+    "astro": "workspace:*",
+    "@astrojs/node": "workspace:*"
+  },
+  "scripts": {
+    "build": "astro build",
+    "preview": "astro preview"
+  }
+}
diff --git a/packages/integrations/node/test/fixtures/image/src/assets/some_penguin.png b/packages/integrations/node/test/fixtures/image/src/assets/some_penguin.png
new file mode 100644
index 000000000000..fad1494c81c8
Binary files /dev/null and b/packages/integrations/node/test/fixtures/image/src/assets/some_penguin.png differ
diff --git a/packages/integrations/node/test/fixtures/image/src/pages/index.astro b/packages/integrations/node/test/fixtures/image/src/pages/index.astro
new file mode 100644
index 000000000000..474a2f0c950a
--- /dev/null
+++ b/packages/integrations/node/test/fixtures/image/src/pages/index.astro
@@ -0,0 +1,6 @@
+---
+import { Image } from "astro:assets";
+import penguin from "../assets/some_penguin.png";
+---
+
+<Image src={penguin} alt="Penguins" width={50} />
diff --git a/packages/integrations/node/test/image.test.js b/packages/integrations/node/test/image.test.js
new file mode 100644
index 000000000000..0834bc175fa4
--- /dev/null
+++ b/packages/integrations/node/test/image.test.js
@@ -0,0 +1,40 @@
+import { expect } from 'chai';
+import nodejs from '../dist/index.js';
+import { loadFixture } from './test-utils.js';
+
+describe('Image endpoint', () => {
+	/** @type {import('./test-utils').Fixture} */
+	let fixture;
+	let devPreview;
+
+	before(async () => {
+		fixture = await loadFixture({
+			root: './fixtures/image/',
+			output: 'server',
+			adapter: nodejs({ mode: 'standalone' }),
+			experimental: {
+				assets: true,
+			},
+		});
+		await fixture.build();
+		devPreview = await fixture.preview();
+	});
+
+	after(async () => {
+		await devPreview.stop();
+	});
+
+	it('it returns images', async () => {
+		const res = await fixture.fetch('/');
+		expect(res.status).to.equal(200);
+
+		const resImage = await fixture.fetch(
+			'/_image?href=/_astro/some_penguin.97ef5f92.png&w=50&f=webp'
+		);
+
+		console.log(resImage);
+		const content = resImage.text();
+		console.log(content);
+		expect(resImage.status).to.equal(200);
+	});
+});
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 0657a76cb26b..85e7f3c03854 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -4620,6 +4620,15 @@ importers:
         specifier: workspace:*
         version: link:../../../../../astro
 
+  packages/integrations/node/test/fixtures/image:
+    dependencies:
+      '@astrojs/node':
+        specifier: workspace:*
+        version: link:../../..
+      astro:
+        specifier: workspace:*
+        version: link:../../../../../astro
+
   packages/integrations/node/test/fixtures/locals:
     dependencies:
       '@astrojs/node':