diff --git a/openpype/hosts/maya/api/customize.py b/openpype/hosts/maya/api/customize.py
index 84742626267..83f481f56e5 100644
--- a/openpype/hosts/maya/api/customize.py
+++ b/openpype/hosts/maya/api/customize.py
@@ -5,7 +5,7 @@
 
 from functools import partial
 
-import maya.cmds as mc
+import maya.cmds as cmds
 import maya.mel as mel
 
 from avalon.maya import pipeline
@@ -31,9 +31,9 @@ def override_component_mask_commands():
     log.info("Installing override_component_mask_commands..")
 
     # Get all object mask buttons
-    buttons = mc.formLayout("objectMaskIcons",
-                            query=True,
-                            childArray=True)
+    buttons = cmds.formLayout("objectMaskIcons",
+                              query=True,
+                              childArray=True)
     # Skip the triangle list item
     buttons = [btn for btn in buttons if btn != "objPickMenuLayout"]
 
@@ -44,14 +44,14 @@ def on_changed_callback(raw_command, state):
         # toggle the others based on whether any of the buttons
         # was remaining active after the toggle, if not then
         # enable all
-        if mc.getModifiers() == 4:  # = CTRL
+        if cmds.getModifiers() == 4:  # = CTRL
             state = True
-            active = [mc.iconTextCheckBox(btn, query=True, value=True) for btn
-                      in buttons]
+            active = [cmds.iconTextCheckBox(btn, query=True, value=True)
+                      for btn in buttons]
             if any(active):
-                mc.selectType(allObjects=False)
+                cmds.selectType(allObjects=False)
             else:
-                mc.selectType(allObjects=True)
+                cmds.selectType(allObjects=True)
 
         # Replace #1 with the current button state
         cmd = raw_command.replace(" #1", " {}".format(int(state)))
@@ -64,13 +64,13 @@ def on_changed_callback(raw_command, state):
         # try to implement the fix. (This also allows us to
         # "uninstall" the behavior later)
         if btn not in COMPONENT_MASK_ORIGINAL:
-            original = mc.iconTextCheckBox(btn, query=True, cc=True)
+            original = cmds.iconTextCheckBox(btn, query=True, cc=True)
             COMPONENT_MASK_ORIGINAL[btn] = original
 
         # Assign the special callback
         original = COMPONENT_MASK_ORIGINAL[btn]
         new_fn = partial(on_changed_callback, original)
-        mc.iconTextCheckBox(btn, edit=True, cc=new_fn)
+        cmds.iconTextCheckBox(btn, edit=True, cc=new_fn)
 
 
 def override_toolbox_ui():
@@ -78,18 +78,29 @@ def override_toolbox_ui():
     icons = resources.get_resource("icons")
 
     # Ensure the maya web icon on toolbox exists
-    web_button = "ToolBox|MainToolboxLayout|mayaWebButton"
-    if not mc.iconTextButton(web_button, query=True, exists=True):
+    maya_version = int(cmds.about(version=True))
+    if maya_version >= 2022:
+        # Maya 2022+ has an updated toolbox with a different web
+        # button name and type
+        web_button = "ToolBox|MainToolboxLayout|mayaHomeToolboxButton"
+        button_fn = cmds.iconTextStaticLabel
+    else:
+        web_button = "ToolBox|MainToolboxLayout|mayaWebButton"
+        button_fn = cmds.iconTextButton
+
+    if not button_fn(web_button, query=True, exists=True):
+        # Button does not exist
+        log.warning("Can't find Maya Home/Web button to override toolbox ui..")
         return
 
-    mc.iconTextButton(web_button, edit=True, visible=False)
+    button_fn(web_button, edit=True, visible=False)
 
     # real = 32, but 36 with padding - according to toolbox mel script
     icon_size = 36
     parent = web_button.rsplit("|", 1)[0]
 
     # Ensure the parent is a formLayout
-    if not mc.objectTypeUI(parent) == "formLayout":
+    if not cmds.objectTypeUI(parent) == "formLayout":
         return
 
     # Create our controls
@@ -106,7 +117,7 @@ def override_toolbox_ui():
 
     if look_assigner is not None:
         controls.append(
-            mc.iconTextButton(
+            cmds.iconTextButton(
                 "pype_toolbox_lookmanager",
                 annotation="Look Manager",
                 label="Look Manager",
@@ -120,7 +131,7 @@ def override_toolbox_ui():
         )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_workfiles",
             annotation="Work Files",
             label="Work Files",
@@ -136,7 +147,7 @@ def override_toolbox_ui():
     )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_loader",
             annotation="Loader",
             label="Loader",
@@ -152,7 +163,7 @@ def override_toolbox_ui():
     )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_manager",
             annotation="Inventory",
             label="Inventory",
@@ -173,7 +184,7 @@ def override_toolbox_ui():
     for i, control in enumerate(controls):
         previous = controls[i - 1] if i > 0 else web_button
 
-        mc.formLayout(parent, edit=True,
-                      attachControl=[control, "bottom", 0, previous],
-                      attachForm=([control, "left", 1],
-                                  [control, "right", 1]))
+        cmds.formLayout(parent, edit=True,
+                        attachControl=[control, "bottom", 0, previous],
+                        attachForm=([control, "left", 1],
+                                    [control, "right", 1]))