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outreach.html
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---
layout: default
redirect_from: "/outreach.shtml"
---
<h1 align="left">
Outreach and teaching materials
</h1>
<p align="left">
The CellProfiler team has developed several educational resources to
introduce people to the joy of answering important biomedical
research questions using software. Biological image analysis is
interdisciplinary - it concretely demonstrates mathematics and
computer science to students in the context of high-impact biomedical
research.
</p>
<h1 align="left">
In-person workshops
</h1>
<blockquote>
<a href="mailto:imagingadmin@broadinstitute.org">Sign up for
notifications</a> of workshops open to the public.
</blockquote>
<h1 align="left">
BLOSSOMS video/activity lesson
</h1>
<blockquote>
<p align="left">
BLOSSOMS (Blended Learning Science or Math Studies) is a large,
free repository of video modules for high school math and science
classes created by "star" teachers from around the world. Each
video is designed for viewing in brief segments, allowing the
in-class teacher between segments to engage the class in an active,
goal-oriented exercise. The goal is not just to learn about an
exciting area of science but also to develop deeper and richer
thinking skills.
</p>
<p align="left">
<strong>Video lesson:</strong> <a href=
"http://blossoms.mit.edu/video/carpenter.html">Discovering
Medicines, Using Robots and Computers</a> [<a href=
"http://www.cpalms.org/Public/PreviewResourceUrl/Preview/18770">listing
in CPALMS</a>]
</p>
</blockquote>
<h1 align="left">
Robots vs Disease activity lesson
</h1>
<blockquote>
<p align="left">
This activity teaches students about a new technology used to
identify genes involved in human disease. The activity uses a
specific example of how to discover genes that promote metastasis,
which is the process of cancer cells spreading throughout the body
from the site of the original tumor. This activity teaches students
how new software works that "looks" at images and learns from the
biologist what types of cells to look for. This hands-on activity
models how the computer learns to recognize cells of interest, and
stars the students as “the computer."
</p>
<p align="left">
<strong>Activity description:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/MuseumOfSciencePresentation/RobotsVsDiseaseActivity.doc">
Robots vs Disease: Modeling Biomedical Research in your Classroom
(.doc)</a>
</p>
<p align="left">
<strong>Materials:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/MuseumOfSciencePresentation/CellPictures.zip">Pictures
of Cells (.pdf)</a>
</p>
<p align="left">
<strong>Presentation Slides (in 3 different formats):</strong>
(<a href=
"http://d1zymp9ayga15t.cloudfront.net/content/MuseumOfSciencePresentation/2008_03_31_MuseumScience.pdf">PDF</a>)
(<a class="contentLink" href=
"http://d1zymp9ayga15t.cloudfront.net/content/MuseumOfSciencePresentation/2008_03_31_MuseumScience_PPT.zip">PowerPoint.zip</a>)
</p>
</blockquote>
<h1 align="left">
<i>C. elegans</i> image analysis written exercise
</h1>
<blockquote>
<p align="left">
This exercise will allow students to learn about how image analysis
can be applied to screening chemicals for antibiotic drugs. The
data is from a published study in which the nematode <i>C.
elegans</i> was used as an animal model to find small molecules
that cure infection by the <i>E.faecalis</i> pathogen. In this
exercise, you will have access to the following materials:<br />
</p>
<ul>
<li>Background information on bacterial resistance, antibiotic
discovery and C. elegans as a model organism for antibiotic
research.
</li>
<li>Images from an actual screen in which several compounds and
extracts were found to rescue the worms from infection but had not
previously been reported to have antimicrobial properties.
</li>
</ul>
<p align="left">
The exercise is written as a set of modules, such that the
activities can be done up until any point. Modules can be combined
to create a lesson plan appropriate for students ranging from
high-school up to upper-level college biology students.
</p>
<p align="left">
<strong>Activity overview and description:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/C_elegansActivity/Overview_Description.pdf">Searching
for new antibiotics using digital images of infected worms
(.pdf)</a>
</p>
<p align="left">
<strong>Materials:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/C_elegansActivity/Images.zip">Images of <i>C.
elegans</i> worms (.TIF)</a>, <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/C_elegansActivity/Pipelines.zip">Pipelines</a>
</p>
<p align="left">
<strong>Written exercise:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/C_elegansActivity/C_elegans_CellProfiler_EducationalExercise.pdf">
(PDF)</a>
</p>
</blockquote>
<a id="translocation"></a>
<h1 align="left">
Image-based screening for quantifying a translocation assay written
exercise
</h1>
<blockquote>
<p align="left">
This exercise will demonstrate how image analysis can be used for
novel drug discovery. Students will use CellProfiler identify and
delineate cells and cellular sub-compartments, and collect and
store measurements from each cell. Afterwards, they will use
CellProfiler Analyst to visualize their data, and use its machine
learning tool to train the computer to distinguish between treated
and untreated cells
</p>
<p align="left">
<strong>Activity overview and written exercise:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/TranslocationActivity/TranslocationData_CP_CPA_Exercise.pdf">
Image-based screening using subcellular localization of FOXO1A in
osteosarcoma cells (.pdf)</a>
</p>
<p align="left">
<strong>Materials:</strong> <a href=
"http://cellprofiler-org.s3.amazonaws.com/TranslocationData.zip">Images
and text file of experimental parameters (.zip)</a>
</p>
</blockquote>
<a id="hepfibcocx"></a>
<h1 align="left">
Using cellular co-culture platforms as a tool for drug discovery
written exercise
</h1>
<blockquote>
<p align="left">
This exercise will introduce students to the image-analysis
challenges in using co-culture systems as part of a novel <i>in
vitro</i> liver model. Students will use CellProfiler to generate a
suite of cellular measurements, followed by training the supervised
learning tool in CellProfiler Analyst to discriminate between
hepatocytes and fibroblasts. The student will then learn how
including additional tailored image features can improve
classification.
</p>
<p align="left">
<strong>Activity overview and written exercise:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/HepatocyteCocxActivity/exercise.pdf">Discovering
drugs by using mixed cell cultures (.pdf)</a>
</p>
<p align="left">
<strong>Materials:</strong> <a href=
"http://d1zymp9ayga15t.cloudfront.net/content/HepatocyteCocxActivity/input_data.zip">Images,
pipeline and text file of experimental parameters (.zip)</a>
</p>
</blockquote>