X - decreases Y - decreases Z != X decreases Z

[TranslatorIssueCreator]

Type: Bug Report

URL: https://ui.test.transltr.io/main/results?l=Lepirudin&i=PUBCHEM.COMPOUND:118856773&t=4&r=0&q=9c30d7a5-be5f-4f44-a12e-376369954f57

ARS PK: 0951aef6-f1a0-4061-9a45-66a6d94767ef

Steps to reproduce:

What genes may be downregulated by:Lepirudin
as 1 example search for TNFRSF1A

Screenshots:

[sandrine-muller-research]

A lot of top answers show the same similar reasoning chain that is not answering the question asked:
GENE X (output/answer) upregulates GENE Y (intermediate node) Has decreased activity or abundance of Lepirudin.
As an example, for TNFRSF1A:

see complete list in test asset sheet.
To note that I did not put TNFRSF1A as a never_show because there is other (weak though) evidence of another correct reasoning path.

[sandrine-muller-research]

Perhaps related to issue #755 but the involved ARA here is BTE.

[sandrine-muller-research]

This type of reasoning overloads the top results : this could be an issue for O&O as well.