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"Extend" of Initial conditions: by default, do not extend for FcRn-complexes (e.g. "Fluvoxamine-FcRn_Complex") (== use PK-Sim knowledge). This should be managed by a check box (e.g. "Do not create for FcRn blabla..") #2355

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Tracked by #2130
rwmcintosh opened this issue Oct 30, 2024 · 1 comment
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@rwmcintosh
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@rwmcintosh rwmcintosh added this to v12 Oct 30, 2024
@PavelBal PavelBal self-assigned this Nov 4, 2024
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PavelBal commented Nov 5, 2024

Okay, so what we need is some kind of Container criteria for molecules that are respected when extending the IC BB.

  • \<Molecule>-FcRn_Complex are present in Plasma, Interstitial, Endosome and "Not in container: BloodOrgan"
  • FcRn only in Plasma, Interstitial, Endosome and "In Container: EndogenousIgG"
  • LigandEndo only "In container: EndogenousIgG"
  • LigandEndo_Complex only in Plasma, Interstitial, Endosome and "In Container: EndogenousIgG"

This would also solve #2356

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