Opening V11 PK-Sim project in PK-Sim and sending a simulation to MoBi does not properly work

[PavelBal]

• Open the Midazolam project from here https://github.com/Open-Systems-Pharmacology/OSP-PBPK-Model-Library/tree/master/Midazolam in PK-Sim 12

• Send the simulation "iv 0.05 mg/kg (2 min)" to MoBi

• Create a new simulation from the existing building blocs

• Try to run the simulation:
  

• Compare simulations: there are tons of differences. How can this be?

E.g. Organism|Volume (plasma) is defined as a sum formula in the building block but not in the simulation! Where are expression values stored?

[Yuri05]

Unit conversion issue probably

[PavelBal]

No, there are just many parameters that are in the simulation and not in the building blocks. E.g. "Weight" is not defined etc..

[Yuri05]

Actually what I meant was "Project conversion issue" 😄

[rwmcintosh]

PK-Sim project conversion

[rwmcintosh]

After recent work for other issues related to ontogeny parameters, those seem to be cleared up but BMI remains

[PavelBal]

In the exported Individual, BMI has neither a value nor a formula :D

[rwmcintosh]

Parameter Rate Definition Organism-BMI has calculation method "Individual_HeightDependent"

But is not contained in the Individual OriginData calculation method cache

If I create a new individual, then the CalculationMethod is part of the OriginData and export/import works.

This must be another project conversion step that needs to be implemented

[rwmcintosh]

The same principal is used in the BSA formula that's shown in the screenshot. Follow both to find the difference

[msevestre]

Individual_HeightDependent

Parameter Rate Definition Organism-BMI has calculation method "Individual_HeightDependent"

But is not contained in the Individual OriginData calculation method cache

If I create a new individual, then the CalculationMethod is part of the OriginData and export/import works.

This must be another project conversion step that needs to be implemented

thanks