You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
MAR04372: 2,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + Pi [c] is currently associated with BPGM (ENSG00000172331), which catalyzes the isomerization of 1,3-bisphosphoglycerate and 2,3-bisphosphoglycerate (i.e. MAR04371, which already has BPGM in its GPR), not the dephosphorylation of 2,3-bisphosphoglycerate (see Uniprot). The correct GPR for MAR04372 is ACYP1 or ACYP2 (ENSG00000119640 or ENSG00000170634), i.e. the same as the current GPR for MAR04370: 1,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + H+ [c] + Pi [c] (see their Uniprot pages).
Proposed Changes:
Change the GPR of MAR04372 from ENSG00000172331 to ENSG00000119640 or ENSG00000170634
The text was updated successfully, but these errors were encountered:
The only paper I can find that specifically associates them with bisphosphoglycerate is this one, but that doesn't directly present any experimental observations and cites an even older source that appears to be a book/textbook I cannot find any digital copies of. Also I'm not even sure what organism(s) it's talking about in that context. Many people seem to cite this paper when they say that ACYP1 and ACYP2 participate in glycolysis in humans and/or mice.
The Problem:
MAR04372: 2,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + Pi [c]
is currently associated with BPGM (ENSG00000172331
), which catalyzes the isomerization of 1,3-bisphosphoglycerate and 2,3-bisphosphoglycerate (i.e.MAR04371
, which already has BPGM in its GPR), not the dephosphorylation of 2,3-bisphosphoglycerate (see Uniprot). The correct GPR forMAR04372
is ACYP1 or ACYP2 (ENSG00000119640 or ENSG00000170634
), i.e. the same as the current GPR forMAR04370: 1,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + H+ [c] + Pi [c]
(see their Uniprot pages).Proposed Changes:
MAR04372
fromENSG00000172331
toENSG00000119640 or ENSG00000170634
The text was updated successfully, but these errors were encountered: