Inaccurate GPR of MAR04372

[Devlin-Moyer]

The Problem:

MAR04372: 2,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + Pi [c] is currently associated with BPGM (ENSG00000172331), which catalyzes the isomerization of 1,3-bisphosphoglycerate and 2,3-bisphosphoglycerate (i.e. MAR04371, which already has BPGM in its GPR), not the dephosphorylation of 2,3-bisphosphoglycerate (see Uniprot). The correct GPR for MAR04372 is ACYP1 or ACYP2 (ENSG00000119640 or ENSG00000170634), i.e. the same as the current GPR for MAR04370: 1,3-bisphospho-D-glycerate [c] + H2O [c] ⇒ 3-phospho-D-glycerate [c] + H+ [c] + Pi [c] (see their Uniprot pages).

Proposed Changes:

• Change the GPR of MAR04372 from ENSG00000172331 to ENSG00000119640 or ENSG00000170634

[haowang-bioinfo]

yes, it does appear that ACYP1 and ACYP2 produce carboxylate and phosphate, while BPGM is irrelevant to dephosphorylation.

just wonder if there is any evidence specifically associating ACYP1 or ACYP2 to substrates of bisphospho-D-glycerate?

[Devlin-Moyer]

The only paper I can find that specifically associates them with bisphosphoglycerate is this one, but that doesn't directly present any experimental observations and cites an even older source that appears to be a book/textbook I cannot find any digital copies of. Also I'm not even sure what organism(s) it's talking about in that context. Many people seem to cite this paper when they say that ACYP1 and ACYP2 participate in glycolysis in humans and/or mice.

[haowang-bioinfo]

fixed in #596