DESCRIPTION

Package: coMethDMR
Title: Accurate identification of co-methylated and differentially methylated
  regions in epigenome-wide association studies
Version: 0.0.0.9001
Authors@R: c(
  person("Lissette", "Gomez", email = "lxg255@miami.edu", role = c("aut", "cre")),
  person("Gabriel", "Odom", email = "gabriel.odom@med.miami.edu", role = c("aut")),
  person("Lily", "Wang", email = "lily.wang@med.miami.edu", role = c("aut")))
Description: coMethDMR identifies genomic regions associated with continuous
  phenotypes by optimally leverages covariations among CpGs within predefined
  genomic regions. Instead of testing all CpGs within a genomic region,
  coMethDMR carries out an additional step that selects co-methylated
  sub-regions first without using any outcome information. Next, coMethDMR tests
  association between methylation within the sub-region and continuous phenotype
  using a random coefficient mixed effects model, which models both variations
  between CpG sites within the region and differential methylation simultaneously. 
Depends:
  R (>= 3.5.0)
License: GPL-3
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.1
Imports:
  BiocParallel,
  bumphunter,
  GenomicRanges,
  IRanges,
  lmerTest,
  stats,
  utils
Suggests: 
  knitr,
  testthat,
  IlluminaHumanMethylation450kanno.ilmn12.hg19,
  IlluminaHumanMethylationEPICanno.ilm10b2.hg19
biocViews:
    DNAMethylation,
    Epigenetics,
    MethylationArray, 
    DifferentialMethylation, 
    GenomeWideAssociation
VignetteBuilder: knitr