Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

somatic variant calling without normal #502

Closed
ericblanc20 opened this issue Apr 22, 2024 · 0 comments · Fixed by #503
Closed

somatic variant calling without normal #502

ericblanc20 opened this issue Apr 22, 2024 · 0 comments · Fixed by #503

Comments

@ericblanc20
Copy link
Contributor

Is your feature request related to a problem? Please describe.
At the moment, somatic variant calling requires that each tumor and a normal sample paired with it. This is impractical for panel data, and even for some WES data.

Describe the solution you'd like
mutect2 can be used without normals, it just needs tweaks in the init file (when no normal is available, the normal bam file is left empty) and in the wrapper (the normal path & normal sample names must be left empty when no normal bam is received from the input dict).

Describe alternatives you've considered
Use germline calling, but there is no freebayes wrapper anymore (see issue #466)

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

Successfully merging a pull request may close this issue.

1 participant